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Báo cáo khoa học: Protein transport into canine pancreatic microsomes A quantitative approach

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:8

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Transport of presecretory proteins into the mammalian rough endoplasmic reticulum involves a protein translocase that comprises the integral membrane proteins Sec61ap, Sec61bp, and Sec61cp as core components. Electron microscopic analysis of protein translocase in rough micro-somal membranes suggested that between three and four heterotrimeric Sec61p complexes form the central unit of protein translocase. Here we analyzed the stoichiometry of heterotrimericSec61pcomplexespresent incotranslationally active protein translocases of canine pancreatic microsomes and various other lumenal and membrane components believed to be subunits of protein translocase and to be involved in covalentmodifications....

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Nội dung Text: Báo cáo khoa học: Protein transport into canine pancreatic microsomes A quantitative approach

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