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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2)

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Table 114-1 Examples of Microbial Ligand-Receptor Interactions Microorganism Type of Microbial Ligand Host Receptor Viral Pathogens Influenza virus Hemagglutinin Sialic acid Measles virus Vaccine strain Hemagglutinin CD46/moesin Wild-type strains Hemagglutinin Signaling lymphocytic activation molecule (SLAM) Human herpesvirus type 6 ? CD46 Herpes simplex virus Glycoprotein C Heparan sulfate HIV Surface glycoprotein CD4 and chemokine receptors CXCR4) (CCR5 and Epstein-Barr virus Envelope protein CD21 (=CR2) Adenovirus Fiber protein Coxsackie-adenovirus receptor (CAR) Coxsackievirus Viral coat proteins CAR and major class I histocompatibility antigens Bacterial Pathogens Neisseria spp. Pili Membrane protein (CD46) cofactor Pseudomonas aeruginosa Pili and flagella Asialo-GM1 Lipopolysaccharide Cystic fibrosis transmembrane conductance regulator (CFTR) ...

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Nội dung Text: Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2)

  1. Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) Table 114-1 Examples of Microbial Ligand-Receptor Interactions Microorganism Type of Microbial Host Receptor Ligand Viral Pathogens Influenza virus Hemagglutinin Sialic acid Measles virus Vaccine strain Hemagglutinin CD46/moesin
  2. Wild-type Hemagglutinin Signaling lymphocytic strains activation molecule (SLAM) Human ? CD46 herpesvirus type 6 Herpes simplex Glycoprotein C Heparan sulfate virus HIV Surface glycoprotein CD4 and chemokine receptors (CCR5 and CXCR4) Epstein-Barr Envelope protein CD21 (=CR2) virus Adenovirus Fiber protein Coxsackie-adenovirus receptor (CAR) Coxsackievirus Viral coat proteins CAR and major histocompatibility class I
  3. antigens Bacterial Pathogens Neisseria spp. Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1 aeruginosa Lipopolysaccharide Cystic fibrosis transmembrane conductance regulator (CFTR) Escherichia coli Pili Ceramides/mannose and digalactosyl residues Streptococcus Hyaluronic acid CD44 pyogenes capsule Yersinia spp. Invasin/accessory β1 Integrins
  4. invasin locus Bordetella Filamentous CR3 pertussis hemagglutinin Legionella Adsorbed C3bi CR3 pneumophila Mycobacterium Adsorbed C3bi CR3; DC-SIGNa tuberculosis Fungal Pathogens Blastomyces WI-1 Possibly matrix dermatitidis proteins and integrins Candida Int1p Extracellular matrix albicans proteins
  5. Protozoal Pathogens Plasmodium Merozoite form Duffy Fy antigen vivax Plasmodium Erythrocyte-binding Glycophorin A falciparum protein 175 (EBA-175) Entamoeba Surface lectin N-Acetylglucosamine histolytica a A novel dendritic cell–specific C-type lectin.
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