Color Atlas of Pharmacology (Part 19): Local Anesthetics

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Color Atlas of Pharmacology (Part 19): Local Anesthetics

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Local Anesthetics circulation would lead to unwanted systemic reactions such as: ¼ blockade of inhibitory CNS neurons, manifested by restlessness and seizures (countermeasure: injection of a benzodiazepine, p. 226); general paralysis with respiratory arrest after higher concentrations. ¼ blockade of cardiac impulse conduction, as evidenced by impaired AV conduction or cardiac arrest (countermeasure: injection of epinephrine). Depression of excitatory processes in the heart, while undesired during local anesthesia, can be put to therapeutic use in cardiac arrhythmias (p. 134). Forms of local anesthesia. ...

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