CYTOKERATINS – TOOLS IN ONCOLOGY
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The second section “HLA and non-MHC genes, Immune Response, and Gene Expression Studies” is dedicated to the molecular and immunological processes of AS. HLA- B*27 is a unique HLA Class I molecule: anchoring peptides in the binding grove of B pocket must have an arginine at the P2, and the free thiol Cys67 residue made B*27 easy to form homodimers in the extracellular domain. Twin studies suggest that the HLA-B*27 accounts for more than 50% of AS susceptibility. Until July 2011, 82 subtypes were described based on nucleotide differences. HLA-B*27:05 is the ancestral and most prevalent subtype in the...
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