Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 50)

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 50)

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Introduction: Ethylene glycol is being widely used as solvents, lubricants and surfactants in industries; for daily necessities, it is being used as a component of cold-reserving materials and of nonfreezing coolants of automobiles. There were cases of accidental and suicidal ingestion of such fluids [1–3]. As toxic actions of ethylene glycol, suppression of central nervous system activities similar to that of alcohol and metabolic acidosis caused by glycolic acid produced from ethylene glycol can be mentioned. The glycolic acid is further metabolized into oxalic acid, which is bound with calcium ions to form the insoluble salt; the salt precipitates in...

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