Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 54)

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 54)

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Introduction: Caffeine, theophylline and theobromine are contained in coffee, chocolate (cocoa) and tea (black and green) as weakly basic natural alkaloids. The structures of the methylxanthine derivatives/xanthine derivatives including the above natural alkaloids together with synthetic ones are shown in Table 4.1 [1]. Theophylline, dyphylline (diprophylline) and proxyphylline are being used mainly as bronchodilators and/or heart stimulants. Caffeine mildly stimulates the central nervous system (CNS), awakens people, relieves them from general fatigue and activates mental activities. It has a relatively wide safe range of doses and its estimated oral lethal dose is said to be about 10 g. Therefore,...

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