Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 55)

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 55)

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Introduction: Nicotine is a main water-soluble alkaloid being contained in the tobacco plant (Nicotiana tabacum), which acts as an inducing compound for smoking-dependence. Twelve kinds of nicotine metabolites are known in rats [1]. Among them, cotinine is the major metabolite of nicotine; the half-life (T1/2) of cotinine is much longer (10–20 h) than that of nicotine (24–84 min). The qualitative analysis of cotinine in urine and saliva is being thus carried out as indicators for smoking during its abstinence therapy and for confirming passive smoking. The cases of ingestion of cigarettes or their butts are household accidents taking place very...

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