HPLC for Pharmaceutical Scientists 2007 (Part 1)

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HPLC for Pharmaceutical Scientists 2007 (Part 1)

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In the modern pharmaceutical industry, high-performance liquid chromatography (HPLC) is the major and integral analytical tool applied in all stages of drug discovery, development, and production. The development of new chemical entities (NCEs) is comprised of two major activities: drug discovery and drug development. The goal of the drug discovery program is to investigate a plethora of compounds employing fast screening approaches, leading to generation of lead compounds and then narrowing the selection through targeted synthesis and selective screening (lead optimization). This lead to the final selection of the most potentially viable therapeutic candidates that are taken forward to...

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