HPLC for Pharmaceutical Scientists 2007 (Part 8A)

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HPLC for Pharmaceutical Scientists 2007 (Part 8A)

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The primary focus of this chapter in on general approaches and considerations toward development of high-performance liquid chromatography (HPLC) methods for separation of pharmaceutical compounds, which may be applied within the various functions in the drug development continuum. It is very important to understand the aim of analysis and the requirements for a particular method to be developed. The aim of analysis of each HPLC method may vary for each developmental area in the drug development process and specific examples are given in Section 8.2. General method development considerations that apply to all reversedphase methods are discussed in Section...

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