Pharmaceutical Coating Technology (Part 5)

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Pharmaceutical Coating Technology (Part 5)

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Surface effects in film coating Michael E.Aulton SUMMARY This chapter will explain the significance of the stages of impingement, wetting, spreading and penetration of atomized droplets at the surface of tablet or multiparticulate cores. It will explain some of the fundamental aspects of solid-liquid interfaces which are important to the process of film coating. This chapter will emphasize the importance of controlling the ‘wetting power’ of the spray and the ‘wettability’ of the substrate, and will explain how this can be achieved by changes in formulation and process parameters. Both surface tension and contact angle are important properties in influencing...

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