PRINCIPLES OF TISSUE ENGINEERING 3RD EDITION - PART 1

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The third edition of Principles of Tissue Engineering attempts to incorporate the latest advances in the biology and design of tissues and organs and simultaneously to connect the basic sciences — including new discoveries in the field of stem cells — with the potential application of tissue engineering to diseases affecting specific organ systems. While the third edition furnishes a much-needed update of the rapid progress that has been achieved in the field since the turn of the century, we have retained those facts and sections that, while not new, will assist students and general readers in understanding this exciting...

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  1. CONTRIBUTORS Claudia Bearzi Jon D. Ahlstrom Cardiovascular Research Institute Section of Molecular and Cellular Biology Department of Medicine University of California, Davis New York Medical College Davis, CA 95616 Valhalla, NY 10595 Julie Albon Daniel Becker School of Optometry and Vision Sciences International Center for Spinal Cord Injury Cardiff University Kennedy-Krieger Institute CF10 3NB Cardiff Baltimore, MD 21205 UK Francisco J. Bedoya Richard A. Altschuler Centro Andaluz de Biología Molecular y Medicina Kresge Hearing Research Institute Regenerativa (Cabimer) University of Michigan C/Américo Vespucio, s/n Department of Otolaryngology and Department of Anatomy & 41092 Isla de la Cartuja, Seville Cell Biology Spain Ann Arbor, MI 48109-0506 Eugene Bell A. Amendola TEI Biosciences Inc. Department of Orthopedics Department of Biology University of Iowa College of Medicine Boston, MA 02127 Iowa City, IA 52242 Timothy Bertram David J. Anderson Tengion Inc. Kresge Hearing Research Institute Winston-Salem, NC 27103 Department of Electrical Engineering & Computer Sciences Department of Biomedical Engineering & Kresge Hearing Valérie Besnard Research Institute Division of Pulmonary Biology University of Michigan Cincinnati Children’s Hospital Medical Center Ann Arbor, MI 48109-0506 Cincinnati, OH 45229-3039 Piero Anversa Christopher J. Bettinger Cardiovascular Research Institute Department of Materials Science and Engineering Department of Medicine Massachusetts Institute of Technology New York Medical College Cambridge, MA 02142 Valhalla, NY 10595 Sangeeta N. Bhatia Anthony Atala Harvard-M.I.T. Division of Health Sciences and Technology/ Wake Forest Institute for Regenerative Medicine Electrical Engineering and Computer Science Wake Forest University School of Medicine Laboratory for Multiscale Regenerative Technologies Winston-Salem, NC 27157 Massachusetts Institute of Technology Cambridge, MA 02139 Kyriacos A. Athanasiou Department of Bioengineering Paolo Bianco Rice University Dipartimento di Medicina Sperimentale e Patologia Houston, TX 77251-1892 Universita “La Sapienza” 324-00161 Rome François A. Auger Italy Laboratoire d’Organogénèse Expérimentale Québec, Qc, G1S 4L8 Anne E. Bishop Canada Stem Cells & Regenerative Medicine, Section on Experimental Medicine & Toxicology Debra T. Auguste Imperial College Faculty of Medicine Division of Engineering and Applied Sciences Hammersmith Campus Massachusetts Institute of Technology W12 ONN London Cambridge, MA 02139 UK FM_P370615.indd xix 6/13/2007 11:03:26 AM
  2. xx C O N T R I B U T O R S C. Clare Blackburn T. Brown MRC/JDRF Centre Development in Stem Cell Biology Department of Orthopedics Institute for Stem Cell Research University of Iowa College of Medicine, University of Edinburgh Iowa City, IA 52242 EH9 3JQ Edinburgh UK Scott P. Bruder Johnson & Johnson Regenerative Therapeutics Michael P. Bohrer Raynham, MA 02767 New Jersey Center for Biomaterials Rutgers, The State University of New Jersey Joseph A. Buckwalter Piscataway, NJ 08854 Department of Orthopedics University of Iowa College of Medicine Roberto Bolli Iowa City, IA 52242 Institute of Molecular Cardiology University of Louisville Louisville, KY 40292 Christopher Cannizzaro Harvard-M.I.T. Division for Health Sciences and Technology Lawrence J. Bonassar Massachusetts Institute of Technology Department of Biomedical Engineering Cambridge, MA 02139 Sibley School of Mechanical and Aerospace Engineering Cornell University Yilin Cao Ithaca, NY 14853 Shanghai Ninth People’s Hospital Shanghai Jiao Tong University, School of Medicine Jeffrey T. Borenstein 200011 Shanghai Biomedical Engineering Center P.R. China Charles Stark Draper Laboratory Cambridge, MA, 02139 Lamont Cathey Michael E. Boulton Department of General Surgery AMD Center Carolinas Medical Center Department of Ophthalmology & Visual Sciences Charlotte, NC 28232 The University of Texas Medical Branch Galveston, TX 77555-1106 Thomas M. S. Chang Department of Physiology Amy D. Bradshaw McGill University Gazes Cardiac Research Institute Montréal, PQ, H3G 1Y6 Medical University of South Carolina Canada Charleston, SC 29425 Yunchao Chang Christopher Breuer Division of Molecular Oncology Department of Pediatric Surgery The Scripps Research Institute Yale University School of Medicine La Jolla, CA 92037 New Haven, CT 06510 Luke Brewster Robert G. Chapman Department of Surgery National Research Council Loyola University Medical Center Institute for Nutrisciences and Health Maywood, IL 60153 Charlottetown, PE, C1A 4P3 Canada Eric M. Brey Department of Biomedical Engineering Alice A. Chen Illinois Institute of Technology Harvard-M.I.T. Division of Health Sciences and Technology Chicago, IL 60616 Massachusetts Institute of Technology and Cambridge, MA 02139 Hines VA Hospital Hines, IL 60141 Faye H. Chen Mairi Brittan Cartilage Biology and Orthopaedics Branch Institute of Cell & Molecular Science National Institute of Arthritis, and Musculoskeletal and Queen Mary’s University of London Skin Diseases E1 2AT London National Institutes of Health UK Bethesda, MD 20892-8022 FM_P370615.indd xx 6/13/2007 11:03:27 AM
  3. xxi CONTRIBUTORS • Gregory R. Dressler Una Chen Department of Pathology Stem Cell Therapy Program University of Michigan Medical Microbiology, AG Chen Ann Arbor, MI 48109 University of Giessen D-35394 Giessen George C. Engelmayr, Jr. Germany Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Richard A.F. Clark Cambridge, MA 02139 Departments of Biomedical Engineering, Dermatology and Medicine Carol A. Erickson Health Sciences Center Department of Molecular and Cellular Biology State University of New York University of California, Davis Stony Brook, NY 11794-8165 Davis, CA 95616 Clark K. Colton Thomas Eschenhagen Department of Chemical Engineering Institute of Experimental and Clinical Pharmacology Massachusetts Institute of Technology University Medical Center Hamburg-Eppendorf Cambridge, MA 02139 D-20246 Hamburg Germany George Cotsarelis Vincent Falanga Department of Dermatology Boston University School of Medicine University of Pennsylvania School of Medicine Department of Dermatology and Skin Surgery Philadelphia, PA 19104 Roger Williams Medical Center Boston, MA 02118 Stephen C. Cowin Department of Mechanical Engineering Katie Faria The City College Organogenesis Inc. New York, NY 10031 Canton, MA 02021 Ronald Crystal Denise L. Faustman Department of Genetic Medicine Immunobiology Laboratory Weill Medical College of Cornell University Massachusetts General Hospital New York, NY 10021 Harvard Medical School Boston, MA 02129 Gislin Dagnelie Dario O. Fauza Lions Vision Center Children’s Hospital Boston Johns Hopkins University School of Medicine Harvard Medical School Baltimore, MD 21205-2020 Boston, MA 02115 Jeffrey M. Davidson Lino da Silva Ferreira Department of Medical Pathology Department of Chemical Engineering Vanderbilt University Massachusetts Institute of Technology Nashville, TN 37235-1604 Cambridge, MA 02139 and and Research Service Center of Neurosciences and Cell Biology VA Tennessee Valley Healthcare System University of Coimbra Nashville, TN 37212-2637 3004-517 Coimbra Portugal Thomas F. Deuel and Departments of Molecular and Experimental Medicine and Cell Biocant Centro de Inovação em Biotecnologia Biology 3060-197 Cantanhede The Scripps Research Institute Portugal La Jolla, CA 92037 Hanson K. Fong Elizabeth Deweerd Department of Materials Science and Engineering Department of Ophthalmology College of Engineering Novartis Institutes for Biomedical Research University of Washington Cambridge, MA 02143 Seattle, WA 98195 FM_P370615.indd xxi 6/13/2007 11:03:27 AM
  4. xxii C O N T R I B U T O R S Howard P. Greisler Peter Fong Department of Surgery and Department of Cell Biology, Department of Biomedical Engineering Neurobiology and Anatomy Yale University Loyola University Medical Center New Haven, CT 06510 Maywood, IL 60153 Lisa E. Freed and Harvard-M.I.T. Division of Health Sciences and Technology Hines VA Hospital Massachusetts Institute of Technology Hines, IL 60141 Cambridge, MA 02139 Farshid Guilak Departments of Surgery, Biomedical Engineering, and R.I. Freshney Mechanical Engineering & Materials Science Centre for Oncology and Applied Pharmacology Duke University Medical Center University of Glasgow Durham, NC 27710 G12 8QQ Glasgow UK Craig Halberstadt Department of General Surgery Mark E. Furth Carolinas Medical Center Wake Forest Institute for Regenerative Medicine Cannon Research Center Wake Forest University Health Sciences Charlotte, NC 28232-2861 Winston-Salem, NC 27101 Brendan Harley Jeffrey Geesin Department of Mechanical Engineering Johnson & Johnson Regenerative Therapeutics Massachusetts Institute of Technology Raynham, MA 02767 Cambridge, MA 02139 Sharon Gerecht Kiki B. Hellman Department of Chemical and Biomolecular Engineering The Hellman Group, LLC The Johns Hopkins University Clarksburg, MD 20871 Baltimore, MD 21218 Abdelkrim Hmadcha Lucie Germain Centro Andaluz de Biología Molecular y Medicina Laboratoire d’Organogénèse Expérimentale Regenerativa (Cabimer) Québec, Qc, G1S 4L8 C/Américo Vespucio, s/n Canada 41092 Isla de la Cartuja, Seville Spain Kaustabh Ghosh Steve J. Hodges Department of Biomedical Engineering Department of Urology Health Sciences Center Wake Forest University School of Medicine State University of New York Winston-Salem, NC 27157 Stony Brook, NY 11794-8165 Walter D. Holder William V. Giannobile The Polyclinic Michigan Center for Oral Health Research Seattle, WA 98122 University of Michigan School of Dentistry Ann Arbor, MI 48106 Chantal E. Holy Johnson & Johnson Regenerative Therapeutics Francine Goulet Raynham, MA 02767-0650 Laboratoire d’Organogénèse Expérimentale Québec, Qc, G1S 4L8 Toru Hosoda Canada Cardiovascular Research Institute Department of Medicine Maria B. Grant New York Medical College Pharmacology & Therapeutics Valhalla, NY 10595 University of Florida Jeffrey A. Hubbell Gainesville, FL 32610-0267 Laboratory for Regenerative Medicine and Pharmacobiology Institute of Bioengineering Warren Grayson Ecole Polytechnique Fédérale de Lausanne (EPFL) Department of Biomedical Engineering CH-1015 Lausanne Columbia University Switzerland New York, NY 10027 FM_P370615.indd xxii 6/13/2007 11:03:27 AM
  5. xxiii CONTRIBUTORS • H. David Humes Joachim Kohn Department of Internal Medicine Department of Chemistry and Chemical Biology Division of Nephrology Rutgers, The State University of New Jerscy University of Michigan Medical School Piscataway, NJ 08854 Ann Arbor, MI 48109 Shaun M. Kunisaki Department of Surgery Donald E. Ingber Massachusetts General Hospital Vascular Biology Program Boston, MA 02114 Departments of Pathology & Surgery Children’s Hospital and Harvard Medical School Matthew D. Kwan Boston, MA 02115 Stanford University School of Medicine Department of Surgery Stanford, CA 94305-5148 Ana Jaklenec Department of Molecular Pharmacology and Biotechnology Themis R. Kyriakides Brown University Department of Pathology Providence, RI 02912 Yale University School of Medicine New Haven, CT 06519 Xingyu Jiang National Center for NanoScience and Technology Eric Lagasse 100080 Beijing McGowan Institute for Regenerative Medicine China Department of Pathology University of Pittsburgh Pittsburgh, PA 15219-3130 Hee-Sook Jun Rosalind Franklin Comprehensive Diabetes Center Robert Langer Chicago Medical School Department of Chemical Engineering North Chicago, IL 60064 Massachusetts Institute of Technology Cambridge, MA 02142 Jan Kajstura Douglas A. Lauffenburger Cardiovascular Research Institute Department of Chemical Engineering Department of Medicine Massachusetts Institute of Technology New York Medical College Cambridge, MA 02139 Valhalla, NY 10595 Kuen Yong Lee Ravi S. Kane Department of Bioengineering Department of Chemical and Biological Engineering Hanyang University Rensselaer Polytechnic Institute 133-791 Seoul Troy, NY 12180 South Korea Annarosa Leri Jeffrey M. Karp Cardiovascular Research Institute Department of Chemical Engineering Department of Medicine Massachusetts Institute of Technology New York Medical College Cambridge MA 02139 Valhalla, NY 10595 John Kay David W. Levine Isotis, Inc. Genzyme Irvine, CA 92618 Cambridge, MA 02142 Amy S. Lewis Ali Khademhosseini Department of Chemical Engineering Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Brigham and Women’s Hospital Cambridge, MA 02139 Harvard Medical School Cambridge, MA 02139 Wan-Ju Li Cartilage Biology and Orthopaedics Branch Salman R. Khetani National Institute of Arthritis, and Musculoskeletal and Harvard-M.I.T. Division of Health Sciences and Technology Skin Diseases Massachusetts Institute of Technology National Institutes of Health Cambridge, MA 02139 Bethesda, MD 20892-8022 FM_P370615.indd xxiii 6/13/2007 11:03:27 AM
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