Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response...
Membrane rafts are microdomains involved in a number of biologically
important processes, including immunoreceptor signalling. Among the
functionally important protein components of these microdomains are
transmembrane adaptor proteins, containing in their intracellular domains
tyrosine residues that can be phosphorylated and bind other cytoplasmic
Csk-binding protein⁄phosphoprotein associated with glycosphingolipid-enriched domains is a transmembrane adaptor protein primarily involved
in negative regulation of T-cell activation by recruitment of C-terminal Src
kinase (Csk), a protein tyrosine kinase which represses Src kinase activity
through C-terminal phosphorylation. Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent
on phosphorylation performed by the Src family kinase Fyn, which docks
onto PAG using a dual-domain binding mode involving both SH3- and
SH2-domains of Fyn....
TheB class cell-attachedephrinsmediate contact-dependent
cell–cell communications and transduce the contact signals
to the host cells through the binding interactions of their
cytoplasmic domains. Two classes of intracellular effectors
of B ephrins have been identified: one contains the PSD-95/
Dlg/ZO-1 (PDZ)domain(for examplePDZ-RGS3), and the
second the Src homology 2 (SH2) domain (e.g. the Grb4
Talins are large adaptor proteins that link the integrin family of adhesion
molecules to F-actin. In vertebrates, there are two talin genes.Talin 1is
essential for integrin-mediated cell adhesion; the role oftalin 2 is unclear.
Here we report a detailed analysis of mammaliantalin 2.
The ultimate goal of cancer research is the development of effective anticancer
therapy. During the last several decades, the discovery of oncogenes, tumor
suppressors, growth factors, signal transduction pathways has dramatically
escalated our understanding of cancer cell biology and mechanisms of cell
transformation.1-3 Hundreds of cellular proteins and pathways have been logically
considered as molecular targets in a mechanism-based approaches of anticancer drug
Yet, the progress in cancer treatment has not paralleled these dramatic achievements
in basic research.
Absence of melanocytes.
Normal number of melanocytes.
Platelet storage defect and restrictive lung disease secondary to deposits of
ceroid-like material; one form due to mutations in β subunit of adaptor protein.
Giant lysosomal granules and recurrent infections.
The differential diagnosis of localized hypomelanosis includes the following primary cutaneous disorders: idiopathic guttate hypomelanosis, postinflammatory hypopigmentation, tinea (pityriasis) versicolor, vitiligo,
chemical leukoderma, nevus depigmentosus (see below), and piebaldism (Table 54-9).
Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment....
In Arabidopsis thaliana, the BTB⁄POZ-MATH (BPM) proteins comprise a
small family of six members. They have been described previously to use
their broad complex, tram track, bric-a-brac⁄POX virus and zinc finger
(BTB⁄POZ) domain to assemble with CUL3a and CUL3b and potentially
to serve as substrate adaptors to cullin-based E3-ligases in plants.
Potassium channel tetramerization domain (KCTD) proteins contain a
bric-a-brac, tramtrak and broad complex (BTB) domain that is most simi-lar to the tetramerization domain (T1) of voltage-gated potassium chan-nels.
Cbl is an adaptor protein and ubiquitin ligase that binds and is phosphory-lated by the nonreceptor tyrosine kinase Src. We previously showed that the
primary interaction between Src and Cbl is mediated by the Src homology
domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.
This study addresses the interactions between the adaptor protein Shb and components involved in T cell signalling, including SLP-76, Gads, Vav and ZAP70. We show that both SLP-76 and ZAP70 co-immunoprecipitate with Shb in Jurkat T cells and that Shb and Vav co-immunoprecipitate when cotransfected in COS cells. We also demonstrate, utilizing fusion protein constructs, that SLP-76, Gads and Vav associate independently of each other to diﬀerent domains or regions, of Shb.
Tubular organs are essential for organisms to establish transport systems for nutrients,
liquids and gases. The development of tubes requires endocytosis of bound ligands,
receptors and proteins at the plasma membrane (Bonifacino and Traub, 2003; Nelson, 2009).
Clathrin coated vesicles (CCVs) organize major routes of cargo selective endocytosis in
higher eukaryotic cells (Conner and Schmid, 2003). The formation of CCVs requires clathrin
molecules. During CCV budding, clathrin molecules assemble to form a cage-like coat
around the nascent vesicle membrane.
Integrin-mediated activation of Cdc42 is essential for cell polarization,
whereas the integrin adaptor protein Cas is required for cell migration dur-ing wound healing. After phosphorylation on tyrosine residues, Cas recruits
the adaptor proteins Crk and Nck to execute integrin-mediated signals.
FE65 is a neural adaptor protein known to interact with a number of pro-teins, including Alzheimer’s amyloid b-protein precursor (APP). Although
several different functions have been proposed for FE65, its primary physi-ological role remains unclear. We previously showed that APP can liberate
FE65 from the membrane as a result of APP phosphorylation, and that
the liberated FE65 translocates into the nuclei of osmotically stressed cells.
The class III sugar transport facilitator GLUT8 co-localizes with the lyso-somal protein LAMP1 in heterologous expression systems. GLUT8 carries a
[D⁄E]XXXL[L⁄I]-type dileucine sorting signal that has been postulated to
retain the protein in an endosomal⁄lysosomal compartment via interactions
with clathrin adaptor protein (AP) complexes.
Fas-associated protein with death domain (FADD) is an essential adaptor
protein in death receptor-mediated signal transduction. During apoptotic
signaling, FADD functions in the cytoplasm, where it couples activated
receptors with initiator caspase-8. However, in resting cells, FADD is pre-dominantly stored in the nucleus. In this study, we examined the modalities
of FADD intracellular trafficking.
The 4-aminobutyrate type A receptor-associated protein (GABARAP) is a
versatile adaptor protein that plays an important role in intracellular vesi-cle trafficking, particularly in neuronal cells. We have investigated the
structural determinants underlying the interaction of GABARAP with cal-reticulin using spectroscopic and crystallographic techniques.
Toll-like receptors and RNA helicase family members [retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated gene-5
(MDA5)] play important roles in the induction of interferon-bas a major
event in innate immune responses after virus infection. TRIF (adaptor pro-tein of Toll-like receptor 3)-mediated and Cardif (adaptor protein of RIG-I
or MDA5)-mediated signaling pathways contribute rapid induction of
interferon-bthrough the activation of interferon regulatory factor-3 (IRF-3)....