Indications in gene therapy clinical trials. The chart divides clinical gene transfer studies by disease classification. A majority of trials have addressed cancer, with monogenic disorders and cardiovascular diseases the next largest
categories. (Reproduced with permission from J Gene Med. New Jersey, Wiley, 2006.)
Gene Transfer for Genetic Disease
Gene transfer strategies for genetic disease generally involve gene addition therapy. This approach most commonly involves transfer of the missing gene to a physiologically relevant target cell. ...
While a significant number of nations have adopted or accepted IFRS, in order
to achieve the true benefits of a uniform set of accounting standards, it is
important that IFRS is adopted by nations in a manner consistent with those
issued by the IASB. In addition, it is equally important that they are applied and
enforced in a consistent manner. Therefore, there must also be a mechanism to
ensure that auditing standards and the practices of auditors facilitate consistent
application of IFRS. Similarly, over time there must be improved coordination
of global regulatory review.
The toxic assets currently plaguing the German banking system are for the most part
complex mortgage-backed securities originating in the US housing market. The
anonymity of the US-based original borrowers and the large number of intermediate
institutions involved in the packaging and onward sale of these securities represent
serious impediments to the identification of the relevant counterparties for debt
restructuring. Hence, there are fewer instruments available for restricting the bad bank’s
losses than in the past.
Alternatives to Transfusion Alternatives to allogeneic blood transfusions that avoid homologous donor exposures with attendant immunologic and infectious risks remain attractive. Autologous blood is the best option when transfusion is anticipated. However, the cost:benefit ratio of autologous transfusion remains high. No transfusion is a zerorisk event; clerical errors and bacterial contamination remain potential complications even with autologous transfusions.
As with most project plans, updates or changes may be required as the project progresses or
changes are approved. Changes or updates may be required due to changes in personnel, scope,
budget, or other reasons. Additionally, updates may be required as the project matures and
additional requirements are needed. The project manager is responsible for managing all
proposed and approved changes to the communications management plan.
The proposed amendments would require certain advertisements for “free credit reports” to
include prominent disclosures designed to prevent consumers from confusing these “free” offers
with the federally mandated free annual file disclosures available through the single centralized
A substantial proportion of patients receiving fibrinolytic therapy for myocardial infarction
with ST-segment elevation have inadequate reperfusion or reocclusion of the
infarct-related artery, leading to an increased risk of complications and death.
We enrolled 3491 patients, 18 to 75 years of age, who presented within 12 hours after
the onset of an ST-elevation myocardial infarction and randomly assigned them to receive
clopidogrel (300-mg loading dose, followed by 75 mg once daily) or placebo.
Women constitute a special group within prisons because of their sex. Although the
characteristics and corresponding needs of women prisoners can vary considerably between
countries, several factors are common to most. These include many mental disorders, a high
level of drug or alcohol dependence, many women experiencing sexual and physical abuse and
violence before or in prison, the neglect of gender-specific health care needs and additional
issues related to the women’s responsibility for children and families.
The importance of self-monitoring to the effective use of insulin therapy and for those at risk
of hypoglycaemia through leisure or work activities (including driving) on oral medications
was noted. The frequency of monitoring that is useful to someone with diabetes is highly
individual and it is inappropriate to put an artificial restriction on this.
In recognition of the relevance and importance of the
financing and investment dimension, the Parties to
the United Nations Framework Convention on Climate
Change (UNFCCC), requested the Secretariat to analyse
and assess investment flows that will be necessary to
address climate change mitigation and adaptation in
an effective and meaningful way, with a special focus
on developing countries’ needs. This publication is
the culmination of the assessment undertaken by the
Challenges for the global response to hiv. This progress, however, is fragile and unevenly distributed. HIV
incidence is increasing in some countries and regions, and too many new infections are still occurring: 2.6
million in 2009 alone, contributing to the current global prevalence of 33.3 million.
Although much reduced
from their peak in 1999, new infections continue to outpace the number of people placed on treatment. Most
people in need still do not have access to antiretroviral therapy, and demand is growing.
This resourceful guide presents art therapy techniques for difficult clients where the typical therapist-client interaction can often be distant, demanding, and frustrating. Offering practical and theoretical information from a wide variety of treatment populations and diagnostic categories; and incorporating individual, group, and family therapy case studies, the text is filled with examples and over 150 illustrations taken from the author’s sixteen years of experience working with hundreds of clients.
The report identifies the human, institutional,
and technological factors—existing and as yet
undeveloped—that must be involved in
building the NHII. The Committee
recommends a strategy that gives the U.S.
Department of Health and Human Services a
key leadership role at the center of a broadly
collaborative process for the public and private
Congenital abnormalities of the kidney and urinary tract are
reported to occur in 5 to 10% of the population . They
represent 25% of the total ultrasonographically diagnosed
malformations that occur in 0.25–0.7% of fetuses. About
1/3 to 2/3 of ESRD in children are due to congenital ab-
normalities of the kidney and urinary tract. In addition, these
abnormalities occur in 23% of patients with chromosomal
aberrations, and 2/3 of patients with abnormalities of other
Carbohydrates are sugars and starches derived from cereals, tubers, roots, and other
substances such as cellulose and lignin from plant cell walls, vessels and woody tissues.
Carbohydrates do mainly provide energy for maintenance and production. A surplus of
energy is stored as body fat.
A part of the carbohydrates is crude fibre (CF), the remaining is nitrogen-free extract (NFE).
The latter consists of sugars, starches and sugar-like substances. Sugars and starches are
much easier to digest than CF.
The Gale Encyclopedia of Mental Health is a valuable
source of information for anyone who wants to
learn more about mental health, disorders, drugs and
treatments. This collection of approximately 450
entries provides in-depth coverage of specific disorders
recognized by the American Psychiatric
Association (as well as some disorders not formally
recognized as distinct disorders), diagnostic procedures
and techniques, therapies, psychiatric medications,
and biographies of several key people who
are recognized for their important work in the field
of mental health.
TIGTA’s audit work is concentrated on high-risk areas and the IRS’s progress in achieving its
strategic goals. To identify FY 2012 high-risk areas for audit coverage, TIGTA uses a risk-
assessment strategy within its core business areas. The Assistant Inspectors General for Audit
advise the Deputy Inspector General for Audit on the major risks facing the IRS in their
respective program areas and annually propose a national audit plan based on perceived risks,
stakeholder concerns, and follow-up reviews of previously audited areas with significant control
The meeting began with educational sessions addressing
Teaching of Surgery in Gynecologic Oncology, Biological
Agents and Targeted Therapies, Nursing and Practice
Innovations, and Pathology along with several industry
sponsored symposia. In addition to the educational sessions
the offerings included Interactive, Free Communication, Meet-
the-Professor Sessions and Tumor Boards covering a wide
range of topics including the Role of Sentinel Node Mapping,
Robotic Surgery, Neo-Adjuvant chemotherapy, Fertility Sparing
Surgery and The New FIGO Staging System to name a few.
In the time it takes you to make just one in-person sales
call, you could stay at your office, pick up the telephone, and
potentially reach dozens, if not hundreds, of potential prospects,
using basic outbound telemarketing efforts.
About half of all deaths from unsafe abortion are in Asia, with most
of the remainder (44%) in Africa.
The unsafe abortion mortality ratio
(the number of unsafe abortion-related deaths per 100 000 livebirths)
varies across regions. For the developing world as a whole, this ratio
was estimated to be 60 in the year 2000. However, the ratio is much
higher in eastern, middle, and western Africa (90–140), and is lower
in northern and southern Africa, western and southeastern Asia, and
Latin America and the Caribbean (10–40).