The molecular definition of tumor antigens, costimulatory signals, and the
possibility to genetically engineer tumor cells as well as simple protocols for
efficient isolation and preparation of dendritic cells (DC) renew the interest in
tumor immunotherapy and vaccination, in particular. Engineering of tumor
cells with the gene of a particular cytokine is a way of releasing that cytokine at
the tumor site. In contrast to bolus administration, it provides a constant supply
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-b1...
Malonyl-CoA, a potent inhibitor of carnitine pamitoyl
transferase-I (CPT-I), plays a pivotal role in fuel selection in
cardiac muscle. Malonyl-CoA decarboxylase (MCD) cata-lyzes the degradation of malonyl-CoA, removes a potent
allosteric inhibition on CPT-I and thereby increases fatty
acid oxidation in the heart. Although MCDhas several Ser/
Thr phosphorylation sites, whether it is regulated by AMP-activated protein kinase (AMPK) has been controversial.
We therefore overexpressed MCD(Ad.MCD) and consti-tutively active AMPK (Ad.
Ever since their discovery adenoviruses have proven to be a
tremendous asset to biologists. Through the study of the adenoviruses,
we have learned not only about the virus structures, mechanisms of viral
replication, but also about eukaryotic gene expression, alternative splicing,
regulation of cell cycle progression, and apoptosis. In the last five years,
there has been an explosion in the use of adenoviruses as vectors for gene
transfer to a variety of mammalian cells.