Molecular dynamics (MD) simulations have played increasing roles in our
understanding of physical and chemical processes of complex systems and in
advancing science and technology. Over the past forty years, MD simulations have
made great progress from developing sophisticated theories for treating complex
systems to broadening applications to a wide range of scientific and technological
fields. The chapters of Molecular Dynamics are a reflection of the most recent progress
in the field of MD simulations....
Plant response to reduced water availability and other abiotic stress (e.g. metals) have
been analysed through changes in water absorption and transport mechanisms and
also by molecular and genetic approach. A relatively new aspects of fruit nutrition are
presented in order to provide the basis for the improvement of some fruit quality
traits. The involvement of hormones, nutritional and proteomic plant profiles together
with some structure/function of sexual components have also been addressed.
A global research community of scientists is teasing out the biochemical mechanisms that regulate normal cellular physiology in a variety of organisms. Much of current research aims to understand the network of molecular reactions that regulate cellular homeostasis, and to learn what allows cells to sense stress and activate appropriate biochemical responses.
A better understanding of the influence of tobacco smoke on the host response to
periodontal infection has been the major concern in numerous studies whereas, limited
research has been published aiming to identify the influence of tobacco smoke on the dental
biofilm. Tobacco smoke has been shown to cause shifts in the microbial species that
comprise dental plaque (Haffajee & Socransky 2001, Kamma et al. 1999, Shiloah et al. 2000,
Umeda et al. 1998, van Winkelhoff et al. 2001, Zambon et al. 1996). In a recent study by our
group (Buduneli et al.
Biotechnology is the scientific field of studying and applying the most efficient methods and techniques to get useful end-products for the human society by using viable micro-organisms, cells, and tissues of plants or animals, or even certain functional components of their organisms, that are grown in fully controlled conditions to maximize their specific metabolism inside fully automatic bioreactors.
In the mid-1990s plant biotechnology burst onto the scene in world agriculture,
beginning a second ‘green revolution’ and precipitating one of the great public debates
of our time. Approximately a decade later, this book describes the impact of genetically
modified (GM) crops on world agriculture, recent advances in the technology and the
areas of research from which the next generation of GM crops is likely to emerge, as well
as addresses the issues of safety and regulation that have dogged the technology,
particularly in Europe.
This book addresses the evolutionary stage of Chemical Engineering and provides an
overview to the state of the art and technological advancements. Chemical
Engineering applications have always been challenging. Optimization of plausible
solutions to problems in economic manner through technology is worth. The script has
been designed to enable the reader to access the desired knowledge on fundamentals
and advancements in Chemical Engineering in a single text.
Tools shape how we think; when the only tool you have is an axe, everything resembles a
tree or a log. The rapid advances in instrumentation in the last decade, which allow us to
measure and manipulate individual molecules and structures on the nanoscale, have caused
a paradigm shift in the way we view molecular behavior and surfaces. The microscopic details
underlying interfacial phenomena have customarily been inferred from in situ measurements
of macroscopic quantities. Now we can see and “finger” physical and chemical
processes at interfaces.
The book "Intraepithelial neoplasia" is till date the most comprehensive book dedicated entirely to preinvasive lesions of the human body. Created and published with an aim of helping clinicians to not only diagnose but also understand the etiopathogenesis of the precursor lesions, the book also attempts to identify its molecular and genetic mechanisms. All of the chapters contain a considerable amount of new information, with an updated bibliographical list as well as the latest WHO classification of intraepithelial lesions that has been included wherever needed.
During the last three decades, important advances have been made in the
available treatments for the loss of skeletal tissue as a result of trauma or
disease. The application of large skeletal allografts and total joint replacement
have become successful and reproducible treatment options. Unfortunately
there still is a significant incidence of failure because of mechanical or
Advanced Computer-Assisted Techniques in Drug Discovery
edited by Han van de Waterbeemd
.Methods and Principles in Medicinal Chemistry
Edited by R. Mannhold P. Krogsgaard-Larsen H. Timmerman
Volume 1 Hugo Kubinyi, QSAR: Hansch Analysis and Related Approaches Volume 2 Han van de Waterbeemd (ed.), Chemometric Methods in Molecular Design Volume 3
Han van de Waterbeemd (ed.), Advanced Computer- Assisted Techniques in Drug Discovery
.Methods and Principles in Medicinal Chemistry
edited by R. Mannhold, P. Krogsgaard-Larsen, H.
After the first edition published in 2007 that became a best seller, the continuous scientific
developments in the field have prompted us to produce the second edition of this book. As it
happens in life and science, some of the novel and promising data presented in the first edition
have been confirmed, some not, and new breakthrough achievements have been accomplished.
Stem Cells in Reproductive Medicine, Basic Science and Therapeutic Potential, second edition,
updates the revolutionary advances in stem cell science that may potentially impact on human
For otolaryngology–head and neck surgeons in training as
residents and fellows, it is a difficult task to keep up with
all of the advances in the basic and clinical sciences that
impact the medical and surgical practice of their specialty.
It is also pertinent to the practice of otolaryngology–head
and neck surgery for interested medical students and lecturers
in medical school faculties who teach students and
resident physicians to have a reference book that clearly
presents the basic principles.
Science progresses by a symbiotic interaction between theory and experiment: theory is
used to interpret experimental results and may suggest new experiments; experiment
helps to test theoretical predictions and may lead to improved theories. Theoretical
Chemistry (including Physical Chemistry and Chemical Physics) provides the concep-
tual and technical background and apparatus for the rationalisation of phenomena in the
chemical sciences. It is, therefore, a wide ranging subject, reflecting the diversity of
molecular and related species and processes arising in chemical systems.
In the second part, all chapters refer to the latest advances in microbial biotechnology
to be used in recombinant protein production as well as heterologous protein
The chapters included in the third section are focused on recent achievements in
molecular biotechnology and genetic engineering.
In the final section, the chapters emphasize the main scientific results that were
accomplished in tissue engineering as an important biotechnological tool in medicine
and health care. ...
Advanced Topics in Biomineralization is a compendium of current topics focusing on processes of formation, organization, as well as mineralization of novel structural materials. From enchondral ossification to the application of biomineralized cement, the subject of biomineralization encompasses a range of diverse disciplines including molecular biology, supramolecular chemistry, materials science and engineering. A common theme in all these areas of research in biomineralization is the ability to utilize strategies from Nature to create functional materials.
This volume on Polyolefins and Styrenics is the first part of a four-
part set on Handbook of Engineering and Specialty Thermoplastics. The
other three parts, to be published in late 2010 and 2011, are on Poly-
ethers and Polyesters; Nylons; Water Soluble Polymers. The aim of
the Handbook is to keep the practitioner abreast of the recent devel-
opments in these subfields as well as to equip the advanced student
with up-to-date knowledge as he/she enters the industrial arena.
Since this book was first published in 1993, the Advanced Paediatric Life Support
(APLS) concept and courses have gone a great way towards their aim of bringing simple
guidelines for the management of ill and injured children to front-line doctors and
Over the years an increasing number of experts have contributed to the work and we
extend our thanks both to them and also to our instructors who unceasingly provide
helpful feedback.The Advanced Paediatric Life Support Course is now well established
in several countries outside the United Kingdom.
Numerous authors proposed chapters on their work, and those presented here are the
fruit of those proposals. As editor of this book, it has been my pleasure to collaborate
with these many, fine contributing scientists. This text brings forth a great amount of
fresh information on the biogeography and ecology of poorly known taxa and
landscapes, and explores biogeographic processes not previously studied. The
assembled work is an anthology of issues in modern biogeography, with topics
ranging across regional to global spatial scales, and ecological to evolutionary
Lung cancer is the leading cause of cancer death among men and women in
the United States with 170,000 deaths per year. This exceeds the sum of the
next three leading causes of death due to cancer: breast, colon, and prostate.
There are over 1 million deaths worldwide due to lung cancer, making it truly
an epidemic. Fewer than 15% achieve a 5-yr survival. The vast majority (85%)
present with advanced disease, although stage I patients may have a 5-yr
survival approaching 70% (1).