Affecting nucleotide

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  • It would have been much easier for me to write this ACKNOWLEDGEMENT if I were a well established scientist of international fame. I could then write in a pastoral manner about sweet recollections of the past, starting with a certain scientist, also internationally famous of course, who came to visit my lab and suggested that I should write such a book. Knowing that the whole world was watching and waiting, I had set aside all the other very important works and devoted most of my time to the writing of this path-blazing masterpiece.

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  • Note that the above list does not include installment premiums. This is because the decision to use installments versus an up-front premium is often a function of the billing system and does not affect written premium. In the U.S., the total of all known future installment premiums is generally booked up front as written premiums. Installments due but not yet collected are categorized in one premium receivable account, while those to-be-billed in the future and not yet due are in another premium receivable account. The above items may apply to either direct...

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  • Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic b-cells, and catalytic activation by a-D-glucose binding has a key regulatory function. Whereas the mechanism of this activation is well understood, on the basis of crystal structures of human GK, there are no similar structural data on ATP binding to the ligand-free enzyme and how it affects its conformation.

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  • We find strong evidence against the view that childhood tele- vision viewing harms the cognitive or educational development of preschoolers. Our preferred point estimate indicates that an additional year of preschool television exposure raises average adolescent test scores by about 0.02 standard deviations. We are able to reject negative effects larger than about 0.03 standard deviations per year of television exposure.

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  • Cytidine in the anticodon second position (position 35) and G or U in position 36 of tRNAArg are required for aminoacylation by arginyl-tRNA synthetase (ArgRS) from Escherichia coli. Nevertheless, an arginine-accepting amber suppressor tRNA with a CUA anticodon (FTOR1D26) exhibits suppression activity in vivo [McClain, W.H. & Foss, K. (1988) Science, 241, 1804 –1807]. By an in vitro kinetic study with mutagenized tRNAs, we showed that the arginylation of FTOR1D26 involves C34 and U35, and that U35 can be replaced by G without affecting the activity.

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  • The gene encoding the mu-opioid receptor (OPRM1) has been reported to associate with a range of substance dependence and HRH2 is the gene coding histamine H2 receptor, the site of action for various compounds, e.g. amitriptiline and mianserin, used in the treatment of psychiatric disorders. Both OPRM1and HRH2 genes contain some single nucleotide polymorphisms (SNPs), including +118A/G in OPRM1 and +398T/C in HRH2, which were reported to change in protein sequences and result in affecting the therapeutic response. ...

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  • The interaction of the homeodomain of the sunflower KNOX protein HAKN1 with DNA was studied by site-directed mutagenesis, hydroxyl radical footprinting and missing nucleoside experiments. Binding of HAKN1 to different oligonucleotides indicated that HAKN1 prefers the sequence TGACA (TGTCA), with changes within the GAC core more pro-foundly affecting the interaction. Footprinting and missing nucleoside experiments using hydroxyl radical cleavage of DNA showed that HAKN1 interacts with a 6-bp region of the strand carrying the GAC core, covering the core and nucleotides towards the 3¢ end....

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  • There have been great strides in using positional cloning to successfully identify the underlying basis of many Mendelian disorders of children. The severity of even these disorders, however, is greatly affected by genetic modifiers and gene- environment interactions. The molecular pathogenesis of many more complex disorders remains unexplained due to the often complex genetic, epigenetic and environmental interactions involved in their etiology. However, there is reason for optimism.

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