Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response...
Mitomycin C undergoes reduction of its quinone function to generate a bifunctional DNA alkylating agent. It is a broadly active antineoplastic agent with a number of unpredictable toxicities, including delayed bronchospasm 12–14 h after dosing and a chronic pulmonary fibrosis syndrome more frequent at doses of 50–60 mg/m2. Cardiomyopathy has been described, particularly in a setting of prior radiation therapy. A hemolytic/uremic syndrome carries an ultimate mortality rate of 25–50% and is poorly treated by conventional component support and exchange transfusion.
While researching this book, I came across a letter in the journal Nature asking for
caution in the current trend for the use of humorous nomenclature for newly
discovered genes1, the author referring to the tumour suppressor gene Pokemon,
which I have briefly described in Chapter 4.
Chemotherapy Unlike many other epithelial malignancies, breast cancer responds to multiple chemotherapeutic agents, including anthracyclines, alkylating agents, taxanes, and antimetabolites. Multiple combinations of these agents have been found to improve response rates somewhat, but they have had little effect on duration of response or survival. The choice among multidrug combinations frequently depends on whether adjuvant chemotherapy was administered and, if so, what type.
Table 104-1 Acute Myeloid Leukemia (AML) Classification Systems
World Health Organization Classificationa
I. AML with recurrent genetic abnormalities AML with t(8;21)(q22;q22);RUNX1/RUNX1T1b
AML with abnormal bone marrow eosinophils [inv(16)(p13q22) or t(16;16)(p13;q22);CBFB/MYH11]b
Acute promyelocytic leukemia [AML with t(15;17)(q22;q12) (PML/RARα) and variants]b
AML with 11q23 (MLL) abnormalities
A young woman confronted with a diagnosis of systemic
lupus erythematosus (SLE) can expect lifelong complications
arising from the disease itself, as well as the therapies
used to treat this condition. About 50–70 per cent of SLE
patients experience inflammation of the kidneys. As such,
the young woman can expect to be treated with high
doses of corticosteroids, often accompanied by the alkylating
The benzoacronycine derivative, S23906-1, was character-ized recently as a novel potent antitumor agent through
alkylation of theN2 positionof guanines inDNA.We show
here that its reactivity towards DNA can be modulated
by glutathione (GSH). The formation of covalent adducts
between GSH and S23906-1 was evidenced by EI-MS, and
the use of different GSH derivatives, amino acids and
dipeptides revealed that the cysteine thiol group is absolutely
required for complex formation because glutathione disul-fide (GSSG) and other S-blocked derivatives failed to react
covalently with S23906-1. ...
Table 81-2 Commonly Used Cancer Chemotherapy Agents
Exam ples of Usual Doses
Direct DNA-Interacting Agents
Liver metabolism required
phosphoramide 100 mg/m2 PO qd Common alkylatora Mesna protects Cardiac dose) against Cystitis mustard + acrolein
(high "high-dose" bladder damage
6 mg/m2 IV day
Topical use in cutaneous lymphoma
Vesicant 1 and day 8 Nausea
1–3 mg/m2 qd PO
From the 3-acetylaminoindan-1-one obtained during the course of our work, we studied the synthesis of novel indanone derivatives as new antitumor agents, by acidic hydrolysis of the acetamide group, diazotisation and alkylation of the amino group and bromination of the cyclopentanic methylene group.