Cancers of the Anus Cancers of the anus account for 1–2% of the malignant tumors of the large bowel. Most such lesions arise in the anal canal, the anatomic area extending from the anorectal ring to a zone approximately halfway between the pectinate (or dentate) line and the anal verge. Carcinomas arising proximal to the pectinate line (i.e., in the transitional zone between the glandular mucosa of the rectum and the squamous epithelium of the distal anus) are known as basaloid, cuboidal, or cloacogenic tumors; about one-third of anal cancers have this histologic pattern.
Anal cancer (ung thư bờ viền hậu môn) khác biệt với rectal cancer (ung thư ruột thẳng) ra sao, chưã trị thế nào? prognosis ra sao? NTM Tôi đọc trên Internet nhưng chả biết người này là ai, nhưng chỉ để ý đến ung thư bờ viền hậu môn (anal canal). Không thấy ai trả lời, nên chỉ tóm tắt như sau: Ung thư đường tiêu hoá từ miệng đến bờ viền hậu môn: cách chữa trị tùy histopathology.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " The influence of smoking and other risk factors on the outcome after radiochemotherapy for anal cancer...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT)...
Standard treatment of anal cancer is a protocol of
combined chemotherapy and radiotherapy.
Typically, a diagnosis of LSIL results only in
more frequent monitoring in case it progresses to
HSIL. When HSIL is diagnosed, treatment may
be called for to reduce the likelihood of progres-
sion to cancer. This may include surgical
removal of the lesions.
Data on the efficacy of treatment are scarce.
However, treatment of cervical lesions has been
shown to be effective in substantially reducing
the risk of progression to cancer....
Mucositis Irritation and inflammation of the mucous membranes particularly afflicting the oral and anal mucosa, but potentially involving the gastrointestinal tract, may accompany cytotoxic chemotherapy. Mucositis is due to damage to the proliferating cells at the base of the mucosal squamous epithelia or in the intestinal crypts. Topical therapies, including anesthetics and barrier-creating preparations, may provide symptomatic relief in mild cases.
Finally, research is needed to identify other
groups that may benefit from anal screening,
including women, and to document the
efficacy of anal screening programs in
lowering the incidence of anal cancer among
those at risk. Widespread screenings of high
risk groups may be a cost effective opportu-
nity to prevent anal cancer and may well
result in lower rates of this disease. Public
health leaders should give serious consider-
ation to encouraging bi-annual screening for
all gay and bisexual men, and annual screen-
ing for those gay and bisexual men who are
living with HIV....
Bangladesh has no organized screening program, but recently the government decided to expand opportunistic
VIA screening, making it one of the first countries to introduce VIA for its national cervical cancer screening
A report on this program14
announced that more than 100,000 women over 30 years of age had been
screened, with a VIA positivity rate of less than 5 percent—a very low rate, which was attributed to extensive
training and to the predominantly Muslim population.
As recognition of the person and of his works, the Spanish Paediatric Association has for the
last six years been running the Jerónimo Soriano Award for the best article published over
the previous year in its official journal Anales de Pediatría (Pérez-Yarza, et al., 2009), having
created for this purpose the Patronato Jerónimo Soriano Board involving various scientific
Institutions and individuals.
The lack of understanding of the mechanisms whereby the above aetiological
factors (genetic and environmental) interact to initiate the complex pathobiology of
schizophrenia is the key reason for the relative lack of progress in the development of novel
drug treatments. All the antipsychotic medication that is currently in use (first and second
generation) is all predicated on the so-called ‘Dopamine Hypothesis’ (discussed below) and
share a common putative mechanism of action, namely dopamine antagonism.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensitymodulated radiation therapy (IMRT) in anal canal cancer...
Infection with HPV is highly prevalent among
gay and bisexual men. This population also
has a high incidence of HPV-associated anal
lesions and cancer. Gay and bisexual men
living with HIV have an even higher inci-
dence and progression of disease.
This is similar to the story for cervical
cancer. However, with strong advocacy and a
concerted effort by researchers, clinicians, and
public health leaders, dramatic reductions in
the incidence of cervical cancer have been
Squamous cell carcinoma in situ, also called Bowen disease, is the earliest form of squamous
cell skin cancer. “In situ” means that the cells of these cancers are still only in the epidermis
and have not invaded the dermis.
Bowen disease appears as reddish patches. Compared with actinic keratoses, Bowen disease
patches tend to be larger (sometimes over 1/2 inch across), redder, scalier, and sometimes
Like invasive squamous cell skin cancers, the major risk factor is too much sun exposure.
Bowen disease can also occur in the skin of the anal and genital areas.
The efficacy of a screen-and-treat program is influenced not only by accuracy of the screening test but also by
the ability of the treatment, in this case cryotherapy, to eliminate CIN2+ lesions identified by screening. While
cryotherapy was highly successful in this trial, eliminating 75 to 77 percent of CIN2+ lesions, this was lower than
previously reported 85 to 90 percent cure rates for clinical trials in developed countries and for less rigorous
studies in developing regions.
Many recent studies have reported that microRNA (miRNA) biogenesis
and function are related to the molecular mechanisms of various clinical
diseases. Several methods, including northern blotting and DNA chip anal-yses, are capable of assessing miRNA-production patterns in cells. How-ever, the development of repetitive monitoring of the miRNA-production
profile in a noninvasive manner is demanded for the application of
miRNAs to human medicine.
Cách đây 14 ngày: Bệnh nhân nam, caucasian, 62 tuổi, do khu nội thương gửi sang clinic về ung thư hỏi ý kiến v/v ung thư ruột thẳng (rectum, trực tràng). Bnhân cách đây 5 năm, tìm ra ung thư prostate, limited stage, bnhân chọn total prostatectomy (không có radiotherapy cho prostate cancer). Cách đây 4 tuần, tự nhiên thấy bựt máu tuơi sau khi đại tiện. Soi ruột già thấy môt vết (lesion) ở khoảng 4 cm cách bờ hậu môn (4 cm from the anal verge) Biopsy thấy đây là carcinoma in situ (adenocarcinoma).
Nowadays most Authors agree that preserving the rectum is useless, so it is sectioned at the
level of anorectal junction. The preparation of the rectum toward anorectal junction is
usually intramesorectal, which rises the risk of bleeding but also reduces the risk of nerve
lesions. However mesorectal excision is mandatory in case of either severe dysplasia or
After pouch construction, ileopouch-anal anastomosis can be either manual or stapled.
(BQ) Part 2 book "General surgery prepare for the MRCS key articles from the surgery journal" presentation of content: Anatomy of the caecum, appendix and colon, anatomy of the rectum and anal canal, the pathology of colorectal polyps and cancers, chemotherapy andradiotherapy for colorectal cancers,... and other contents.