For the last 60 or so years the chemotherapy of bacterial infections has been dominated
by natural products and their semi-synthetic variants. Although the term antibiotic
was initially used exclusively to describe those anti-bacterials of natural or
semi-synthetic origin, it has become broadened in common usage to include antibacterial
agents of purely synthetic origin as well. The emphasis of this chapter will be
on the discovery of novel prototype structures that represent the different classes of
This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes - the actinomycetes - were discovered in the latter part of the nineteenth century, but remained a 'Cinderella' group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic after penicillin to become a medical marvel.
Antibiotic agents have been in widespread and largely effective therapeutic use since their
discovery in the 20th century. However, the emergence of multi-drug resistant pathogens now presents
an increasing global challenge to both human and veterinary medicine. It is now widely acknowledged
that there is a need to develop novel antimicrobial agents to minimize the threat of further antimicrobial
(BQ) Part 1 book "Textbook of organic medicinal and pharmaceutical chemistry" presents the following contents: Drug design strategies, metabolic changes of drugs and related organic compounds, biotechnology and drug discovery, immunobiologicals, anti infective agents, antibacterial antibiotics, antiviral agents,...
When discussing the antibiotic breakthrough of penicillin, the name which is most often
associated with its discovery tends to be Alexander Fleming. While this is not completely false,
there are many other factors as well as persons which aided in uncovering penicillin’s full
potential in human uses.