With parallel breakthroughs occurring in molecular biology and nanoscience/technology, the newly
recognized research thrust on “nanomedicine” is expected to have a revolutionary impact on the
future of healthcare. To advance nanotechnology research for cancer prevention, diagnosis, and
treatment, the United States National Cancer Institute (NCI) established the Alliance for
Nanotechnology in Cancer in September 2004 and has pledged $144.3 million in the next five years
(for details, visit http://nano.cancer.gov).
It has been said that the control of disease has three goals, which, in
increasing order of attraction are palliation, cure, and prevention. For most types
of disseminated cancer, medical science has achieved only the first of these
objectives, while for some malignancies the side effects of the therapeutic agents
employed rival the disease itself in precluding a desirable quality of life.
A number of drugs used in cancer chemotherapy induce oxidative
stress by generation of oxygen free radicals (ROS) which might
be an alternative mechanism for their cytotoxic effect via indu-cing apoptosis. In order to clarify the roles of antioxidants in
chemotherapy, we investigated Quercetin (3,3’,4’,5,7-pentahyd-roxyflavone) and N-acetylcysteine (NAC) in different cell types
treated with anticancer drugs. We studied cytotoxic activity of
Topotecan alone and/or in combination with Quercetin in two
human breast cancer cell lines, MCF-7 and MDA-MB-231. ...