Antitumoral potential

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  • Currently, adult cells seem to have certain advantages regarding rapid clinical translation. Most biomaterials used in Tissue Engineering are based on acellular matrices or polyglycolic acid. Both materials must provide tissue support until the cells produce their own extracellular matrix. Ideally, they degrade thereafter without any toxic byproducts. Over the last years we started to understand the influence of the biomechanical environment allowing these cell-biomaterial composites to unfold their full functional potential.

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  • The goal of the Child Health program is “to enable all children to attain and sustain optimal health and develop- mental potential.” (1) Achievement of this goal involves a complex interplay of internal and external factors for families and their children. Accordingly, the Child Health Program Standard is structured around six key areas: positive parenting; breastfeeding; healthy family dynamics; healthy eating, healthy weights and physical activity; growth and development; and oral health.

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  • Tham khảo sách 'committee on toxicity of chemicals in food, consumer products and the environment - subgroup report on the lowermoor water pollution incident', khoa học tự nhiên, công nghệ môi trường phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • The model yields the following results. First, the model is consistent with volatility clustering or GARCH e¤ects. The market price of risk, which is the instantaneous component of stock return volatility, has three components: endowment risk, sentiment risk and solvency risk. These three components are persistent, hence the model reproduces volatility clustering or GARCH e¤ects. Endowment risk is persistent because the "two-trees" feature of the model imply that endowment risk is proportional to the shares of aggregate endowment, which ‡uctuate randomly between zero and one.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes

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  • Single sampling devices and methods have their limitations in obtaining adequate smears from the cervix. A combination of two devices, usually spatula and endocervical brush, give better results. Triple smear or the vaginal-cervical-endocervical (VCE) technique can provide the best results. However, feasibility and cost factor need to be taken into consideration. In postmenopausal women, the squamo-columnar junction recedes making it difficult to obtain good amount of endocervical cells and cells from TZ.

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  • Establish a clear network access control policy. It is often the case that the administrators of grid resources are not the same individuals as those of site access control systems (e.g. firewalls). Consequently, it is important for the reliability and availability of grid services that the connectivity requirements are properly communicated and agreed by the network managers. This will reduce the likelihood of ports being closed unexpectedly and facilitate the proper monitoring of traffic.

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  • Destinations are some of the most difficult entities to manage and market, due to the complexity of the relationships of local stakeholders (Sautter and Leisen,1999). Managing and marketing destinations is also challenging because of the variety of stakeholders involved in the development and production of tourism products. The destination experience is essentially comprised of regions, resources and amalgams of tourism facilities and services, which often do not belong to individuals.

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  • The door to my room banged open so hard that it sent a pile of books tumbling off my shelf. One of them bounced off my cheekbone, sending me reeling back, head cracking against the tiny, grimy window. I wrapped my head in my hands and pushed myself back into the corner. Dad's big hands grabbed me. He'd been a scrapper when he was my age, a legendary fighter well known to the Bradford coppers. In the years since he'd taken accent training and got his job working the phone, he'd got a bit fat and lost half a step, but in my mind's eye, I still...

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  • There is an urgent need to develop new innovative therapies for the control of advanced cancer. The combination of antigen-specific immunotherapy with the employment of immunomodulatory agents has emerged as a potentially plausible approach for the control of advanced cancer. Methods: In the current study, we explored the combination of the DNA vaccine encoding calreticulin (CRT) linked to human papillomavirus type 16 (HPV-16) E7 antigen (CRT/E7) with the TLR7 agonist imiquimod for their ability to generate E7-specific immune responses and antitumor effects in tumor-bearing mice.

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  • Intermediate-risk patients are those with any of the following criteria: microscopic tumour invasion into the perithyroidal tissues at initial surgery, cervical lymph node metastases or 131I uptake outside the thyroid bed on the initial post-treatment scan, or tumour with aggressive histology or vascular invasion. Finally, high-risk patients have macroscopic tumour invasion, incomplete tumour resection, distant metastases or elevated thyroglobulin out of proportion to what is seen on the post-treatment scan (Cooper et al., 2009).

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  • Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3.

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  • The Samuel S. Fleisher Art Memorial is the nation’s oldest tuition-free arts education program. It provides arts classes for children and adults of all economic backgrounds and skill levels, both at its main facility in South Philadelphia and through its Community Partnerships in the Arts program. Fleisher’s artist residency programs in public schools and neighborhood organizations reach families throughout the city who otherwise lack access to high-quality arts education. Centers like the Fleisher Art Memorial serve as critical relationship intermediaries.

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  • Conventional approaches to health in poor countries focus on disease–specific interventions and their cost effectiveness, implemented via the path of least resistance with a strong emphasis on short term results. The upshot is that sys- temic problems which underlie poor health, failing health systems, and health inequity are circumvented. Long–term, sustainable strategies are rarely devel- oped or deployed. The crisis may change its spots, expressing itself in different diseases, populations or geographic areas, but it essentially continues unabated.

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  • The average number of living children is lower in Phnom Penh than in the five provinces. This apparently is the result of lower past fertility levels of current Phnom Penh elderly rather than higher losses of children through mortality. In fact, respondents in Phnom Penh report fewer deaths of their children than do those in the provinces (results not shown). Older elders average somewhat smaller numbers of surviving children than younger elders.

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  • This system, designed in cooperation with the banking industry, is based on chipcard technology and corresponds to the electronic cash system above. The only difference is the possibility of offline authorisation. An authorisation up to a certain limit laid down individually by the issuing bank is stored on the bank card’s chip. This amount decreases with each payment and, as long as the remaining amount is sufficient, transactions are authorised offline. In order to pay, the customers must enter their PIN, which is validated on the chip.

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  • Federal funds are the heart of the money market in the sense that they are the core of the overnight market for credit in the United States. Moreover, current and expected interest rates on federal funds are the basic rates to which all other money market rates are anchored. Understanding the federal funds market requires, above all, recognizing that its general character has been shaped by Federal Reserve policy. From the beginning, Federal Reserve regulatory rulings have encouraged the market's growth.

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  • The contributors to the conference comprised a mixture of art historians, curators, museum studies lecturers, anthropologists, archaeologists and artists, and the conference timetable positioned established academics alongside scholars at an earlier stage in their research and writing careers.

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  • An imposing barrier to entry for current plant-derived materials, and the issue most often debated, is the competitive cost situation. In many cases, the current cost of using plant-based materials is viewed as being relatively high, and not competitive with hydrocarbon-based processes. However, the cost-competitive situation contains several highly complex interactions among the key factors: value of product, cost of materials, volume of throughput, degree of processing required, and performance of the building blocks used.

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  • A younger investor, less concerned about these issues, may not be sat- isfied with the lower expected return that inflation hedging implies. It follows from a model with additional hedge portfolios that an OE portfolio for performance evaluation should have the same exposures as the managed portfolio to be evaluated, not just with respect to the overall market, but also with respect to the other relevant risk factors. A related asset pricing model is the Arbitrage Pricing model of Ross (APT, 1976), which allows for several risk factors to determine assets’ expected returns.

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