Antiviral drugs

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Antiviral drugs against hepatitis C virus

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  • (BQ) Part 2 book "Colour atlas of pharmacology" presentation of content: Hypnotics, psychopharmacologicals, local anesthetics, antibacterial drugs, antiviral drugs, therapy of selected diseases,... and other contents.

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  • The development of antiviral drugs is still in its infancy with rapid changes and progressive milestones encountered almost daily. By the time this book is distributed, new drugs may have already been added. This is particularly true for the antiretroviral drugs, which seem to be growing in number exponentially to the casual observer trying to keep abreast of recent advances in this field. As

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  • The field of antiviral therapy—both the number of antiviral drugs and our understanding of their optimal use—continues to lag behind the field of antibacterial drug treatment, in which 70 years of experience have now been accumulated, but significant progress has been made in recent years on new drugs for several viral infections. The development of antiviral drugs poses several challenges. Viruses replicate intracellularly and often employ host cell enzymes, macromolecules, and organelles for synthesis of viral particles.

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  • THERAPY AND PROPHYLAXIS A few antiviral drugs are available for clinical use in special therapeutic and prophylactic situations. Immunoglobulins and vaccines have been prepared for prophylaxis against a considerable number of virus infections. LABORATORY DIAGNOSIS Virus, viral antigen or viral genome may be detected in the early phase of acute disease by electron microscopy, immunological or molecular biological methods or virus isolation. Serologically the diagnosis can be made by demonstration of seroconversion, antibody titre rise or specific IgM....

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  • Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swineorigin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious public concern. Although vaccination is the primary strategy for preventing infections, influenza antiviral drugs play an important role in a comprehensive approach to controlling illness and transmission. In addition, a search for

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  • (BQ) Part 1 book "Textbook of organic medicinal and pharmaceutical chemistry" presents the following contents: Drug design strategies, metabolic changes of drugs and related organic compounds, biotechnology and drug discovery, immunobiologicals, anti infective agents, antibacterial antibiotics, antiviral agents,...

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  • Each year, 8.8 million patients are newly diagnosed with active TB and 1.6 million patients die of TB. The rapid spread of the human immunodeficiency virus has fueled the TB epidemic, especially in sub-Saharan Africa, where 28% of TB patients are HIV positive (WHO 2007). The current first-line treatment for TB is a multidrug regimen consisting of rifampin, isoniazid, pyrazinamide, and ethambutol (RIZE). Several major problems are associated with the currently available TB treatment.

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  • Velocity encoded phase-contrast magnetic resonance imaging (VE-PC MRI) is another imaging technique used to noninvasively measure Achilles tendon strain and changes in its force-displacement relationship concomitant with chronic unloading and subsequent recuperation. This technique will be reviewed in terms of its ability to quantify the Achilles tendon Young’s modulus (MPa) from a stress-strain curve.

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  • Because the hair shaft is the chromophore, it is essential that the hair shaft is present in the hair follicle at the time of treatment. Patients are therefore not allowed to pluck, wax, or have elec- trolysis for at least six weeks before the laser treatment. Shaving and depilatory creams are al- lowed because they leave the hair shaft in the follicle. It is important to take a history, including an endocrine history. Female patients with hirsutism can be treated regardless of the cause. Patients with a history of herpes simplex 1 or 2 should be put on oral antiviral drugs (Zovirax® or...

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  • The seventh edition of Introductory Clinical Pharmacology reflects the ever-changing science of pharmacology and the nurse’s responsibilities in administering pharmacologic agents. All information has been updated and revised according to the latest available information to prepare nurses to meet the challenges of safely administering medications. The text prepares the nurse to meet the challenges of the 21st century by promoting critical thinking and problem solving when administering medications....

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  • Presently, there is no specific effective antiviral drugs and vaccine available for the treatment of HFMD. Symptomatic treatment is given to provide relief from fever, aches, or pain from the mouth ulcers. Dehydration is a concern because the mouth sores may make it difficult and painful for children to eat and drink. Should their affected children be having fever, the parents are advised to dress their children in light, thin clothing, to do tepid sponging with water (room temperature) as often as necessary, and to expose them under the fan.

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  • The crystal structures of the wild-type HIV-1 protease (PR) and the two resistant variants, PRV82Aand PRL90M,have been determined in complex with the antiviral drug, indi-navir, to gain insight into the molecular basis of drug resistance. V82A and L90M correspond to an active site mutation and nonactive site mutation, respectively. The inhibition (Ki)of PRV82Aand PRL90Mwas 3.3- and 0.16-fold, respectively, relative to the value for PR. They showed only a modest decrease, of 10–15%, in theirkcat /Kmvalues relative to PR. ...

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  • HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....

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  • Plant flavonoids are polyphenolic compounds, commonly found in vegeta-bles, fruits and many food sources that form a significant portion of our diet. These compounds have been shown to interact with several ATP-bind-ing cassette transporters that are linked with anticancer and antiviral drug resistance and, as such, may be beneficial in modulating drug resistance. This study investigates the interactions of six common polyphenols; querce-tin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. ...

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  • Viruses present a more difficult problem of chemotherapy than do higher organisms, e.g. bacteria, for they are intracellular parasites that use the metabolism of host cells. Highly selective toxicity is, therefore, harder to achieve. Identification of differences between viral and human metabolism has led to the development of effective antiviral agents, whose roles are increasingly well defined.

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