Bacterial genomes

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes...

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  • Nowadays, with over a thousand bacterial genomes sequenced, even greater opportunities have opened for experimental or computational global analysis of metabolism, physiology, and evolution. In particular, the access to comprehensive sets of molecular components (genes, proteins, regulatory signals) is at the basis of the development of novel integrative approaches, aiming at understanding the function of specific sets of these components (operons, regulons, metabolic pathways, protein complexes, etc.) in the context of the whole organism.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A Protein Similarity Approach For Detecting Prophage Regions In Bacterial Genomes...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Small variable segments constitute a major type of diversity of bacterial genomes at the species level...

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  • Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3.

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  • Over the past several years, scientists from the United States and around the world have been using a technique called DNA sequencing to unlock the genetic code of many different organisms. With code in hand, scientists can design sophisticated experiments that will inform our understanding of how an organism develops and functions. To date, they have carried out partial or complete DNA sequencing on human, mouse, rat, bacterial, and plant genomes. A major finding that was confirmed from these efforts is that most biologic functions are genetically conserved within and between species....

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  • The metabolic network is an important biological network which consists of enzymes and chemical compounds. However, a large number of meta-bolic pathways remains unknown, and most organism-specific metabolic pathways contain many missing enzymes. We present a novel method to identify the genes coding for missing enzymes using available genomic and chemical information from bacterial genomes.

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  • Chapter 14 - Prokaryotic and organelle genetics. This chapter begins with a discussion of the origins of yeast mitochondrial work. It then discusses the development of Chlamydomonas reinhardtii as a model organism. It also shows how early work on the organelle genetics of Chlamydomonas and yeast were carried out relatively independently; but inevitably the rationales soon paralleled one another.

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  • Periodontitis is a chronic infection that results from the interaction of periodontopathogenic bacteria and host inflammatory and immune responses and is the most common bacterial infection worldwide. Estimates reveal that 10-15 % of adults have advanced periodontitis, and periodontal disease can contribute to widespread oral health dysfunction and enhanced susceptibility to other systemic diseases (Pussinen et al. 2007).

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  • Inflammatory bowel disease research is changing. Progress in defining and treating these diseases is advancing in lock step with the furious pace of technological advances that continue to refine the tools of discovery. With sequencing of the entire genome completed, genetics research is providing direction for molecular and immunological in vivo and in vitro investigation, which in turn directs the development of targeted therapeutics.

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  • During the past two decades, reductionist biological science has generated new empirical data on the molecular foundations of biological structure and function at an accelerating rate. The list of organisms whose complete genomes have been sequenced is growing by the week. Annotations of these sequences are becoming more comprehensive, and databases of protein structure are growing at impressive, indeed formerly unimaginable rates.

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  • Take molecular genetics and bioinformatics for example; these are perhaps two of the most exciting areas of biology and are beginning to have an impact on other areas of medical therapeutics such as cancer and diabetes, and provide a signpost to ‘personalised medicine’. Yet recent genome wide association (GWAS) studies of large samples, have demonstrated that in schizophrenia around 1000 or more genetic variants of low penetrance may be implicated in the heritability of schizophrenia.

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  • In order to establish the preferred shopping places for food, consumers were asked to indicate what shop they traditionally buy their groceries from. Six places were identified from past research as: supermarket, spaza shops (which are common in rural areas), Grocery stores, Farmers markets such as the Kei Fresh produce in Mthatha or the farmers market in Wilsonia, East London, Street vendors or the farm gate. Respondents’ were free to mark all the choices. An overwhelming majority of the respondents, 96% in the Transkei and 89.

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  • Aidan Budd*, Stephanie Blandin*, Elena A Levashina† and Toby J Gibson* Addresses: *European Molecular Biology Laboratory, 69012 Heidelberg, Germany. †UPR 9022 du CNRS, IBMC, rue René Descartes, F-67087 Strasbourg CEDEX, France. Correspondence: Toby J Gibson. E-mail: toby.gibson@embl.de reviews Published: 26 May 2004 Genome Biology 2004, 5:R38 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/R38 Received: 20 February 2004 Revised: 2 April 2004 Accepted: 8 April 2004 © 2004 Budd et al.

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  • This book is an outgrowth of the George Fisher Baker Lecture series presented by one of us (C.R.C.) at Cornell University in the fall of 1992. This author is tremendously grateful to all those at Cornell who made this occasion truly memorable, personally, and most pro- ductive, intellectually. Included especially are Jean Fréchet, Barbara Baird, John Clardy, Jerrold Meinwald, Fred McLafferty, Benjamin Widom, David Usher, and Quentin Gibson, among many others.

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  • The view has been widely held that pepsin-like aspartic proteinases are found only in eukaryotes, and not in bacteria. However, a recent bioinfor-matics search [Rawlings ND & Bateman A (2009)BMC Genomics10, 437] revealed that, in seven of 1000 completely sequenced bacterial genomes, genes were present encoding polypeptides that displayed the requisite hall-mark sequence motifs of pepsin-like aspartic proteinases.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genomics and the bacterial species problem...

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  • Published: 5 April 2004 Genome Biology 2004, 5:R37 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R37 Received: 15 January 2004 Revised: 26 February 2004 Accepted: 11 March 2004 reports © 2004 Baerends et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and

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  • The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication.

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