The increasing awareness of the importance of chirality in the context of biological activity
has stimulated a growing demand for efficient methods for industrial synthesis of pure
enantiomers including chiral antiinflammatory drugs such as naproxen (Xin et al., 2001) and
ibuprofen (Lee et al., 1995; Ducret et al., 1998; Xie et al., 1998; Arroyo et al., 1999; Chen and
Tsai, 2000); antihypertensive agents such as angiotensin-converting enzyme (ACE) inhibitors
(e.g., captopril, enalapril, ceranopril, zofenapril, and lisinopril); and the calcium channel-
blocking drugs such as diltiazem.