Xem 1-7 trên 7 kết quả Biochemical barriers
  • Interactions between astrocytes and blood vessels are essential for the for-mation and maintenance of the blood–neural barrier (BNB). Astrocyte-derived A-kinase anchor protein 12 (AKAP12) influences BNB formation, but the mechanism of regulation of BNB functions by AKAP12 is not fully understood.

    pdf16p media19 06-03-2013 16 2   Download

  • Cell membranes act as barriers to most, but not all, molecules. The development of a cell membrane that could allow some materials to pass while constraining the movement of other molecules was a major step in the evolution of the cell. Cell membranes are differentially (or semi-) permeable barriers separating the inner cellular environment from the outer cellular (or external) environment.

    ppt35p nhocbuonthich 26-07-2011 45 9   Download

  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

    pdf0p echbuon 02-11-2012 22 2   Download

  • The conformational dynamics of NADH oxidase from Thermus thermophiluswas modulated by the Hofmeister series of anions (H2PO4 – ,SO4 2– ,CH3COO – ,Cl – ,Br – ,I – , ClO4 – ,SCN – ) in the concentration range 0–3M. Both cha-otropic and kosmotropic anions,at high concentration, inhibit the enzyme by different mechanisms. Chaotropic anions increase the apparent Michaelis constant and decre-ase the activation barrier of the reaction. Kosmotropic ani-ons have the opposite effect.

    pdf10p dell39 03-04-2013 12 2   Download

  • The prion-forming domain comprising residues 218–289 of the fungal prion HET-s forms infectious amyloid fibrils at physiological pH. Because a high-resolution molecular model for the structure of these fibrils exists, it constitutes an attractive system with which to study the mechanism of amy-loid assembly.

    pdf12p vinaphone15 25-02-2013 3 1   Download

  • Epithelial mucins are large complex cell surface and secreted glycoproteins produced by mucosal epithelial cells. Mucins are a major component of the interface between the external world and mucosal tissues, where they provide lubrication, hydration, and a biological and physical barrier to potential toxins, particles, and pathogens. Mucins provide many challenges to researchers due to their large size, complex biochemical nature, and the viscous gels that they form when secreted.

    pdf342p hotmoingay 04-01-2013 21 3   Download

  • The recent convergence of genetic and biochemical evidence on the activit-ies of lipoxygenase (LOX) enzymes has implicated the production of hep-oxilin derivatives (fatty acid epoxyalcohols) in the pathways leading to formation of the water-impermeable barrier of the outer epidermis.

    pdf9p galaxyss3 19-03-2013 13 2   Download

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