Physiological and biochemical responses induced by salt stress were studied in laboratory-grown young plants of the mangrove, Bruguiera gymnorrhiza. The growth rates and leaf areas were highest in the culture with 125 mM NaCl. Transpiration rates showed a diel periodicity when the plants were placed in water, but the oscillatory cycles disappeared for plants placed in higher
A global research community of scientists is teasing out the biochemical mechanisms that regulate normal cellular physiology in a variety of organisms. Much of current research aims to understand the network of molecular reactions that regulate cellular homeostasis, and to learn what allows cells to sense stress and activate appropriate biochemical responses.
Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs...
Cerebral ischemia triggers robust phosphorylation of cAMP response ele-ment-binding protein (CREB) and CRE-mediated gene expression in neu-rons. Glutamate receptor activation and subsequent calcium influx may
activate CREB shortly after ischemia.
The molecular response to hypoxia stress in aquatic invertebrates remains
relatively unknown. In this study, we investigated the response of the Pacific
oyster Crassostrea gigasto hypoxia under experimental conditions and
focused on the analysis of the differential expression patterns of specific
genes associated with hypoxia response. A suppression subtractive hybridiza-tion method was used to identify specific hypoxia up- and downregulated
genes, in gills, mantle and digestive gland, after 7–10 days and 24 days of
The transcription factor serum response factor (SRF) regulates expression of growth factor-dependent genes and muscle-speciﬁc genes in vertebrates. Homologous factors regulate diﬀerentiation of some ectodermic tissues in invertebrates. To explore the molecular basis of these diﬀerent physiological functions, the functionality of human, Drosophila melanogaster and Artemia franciscana SRFs in mammalian cells has been compared in this article. D. melanogaster and, to a lesser extend, A.
Ultrasensitive responses are common in cellular information transfer
because they allow cells to decode extracellular stimuli in an all-or-none
manner. Biochemical responses are usually analyzed by fitting the Hill
equation, and the estimated Hill coefficient is taken as a measure of sensi-tivity. However, this approach is not appropriate if the response under con-sideration significantly deviates from the best-fit Hill equation.
The promoter of the early growth response gene (Egr-1)
has been described to be activated by ionizing radiation,
and it seems to be clear that this process involves dierent
mitogen activated protein (MAP) kinases, dependent on
the speci®c cell type examined. However, early steps
leading to activation of the corresponding pathways and
thus to overexpression of Egr-1 are not well understood.
The product of theARO10gene from Saccharomyces cerevisiaewas ini-tially identified as a thiamine diphosphate-dependent phenylpyruvate decar-boxylase with a broad substrate specificity. It was suggested that the
enzyme could be responsible for the catabolism of aromatic and branched-chain amino acids, as well as methionine.
Effective new treatments of heart disease are based on a refined understanding of
cellular function and the heart's response to environmental stresses. Not surprisingly
therefore, the field of experimental cardiology has experienced a phase of rapid exponential
growth during the last decade. The acquisition of new knowledge has been so
fast that textbooks of cardiology or textbooks of cardiovascular physiology are often
hard-pressed to keep up with the most important conceptual advances.
Estuaries are areas of high productivity, crucial in the life histories of many fish,
invertebrates, and birds, for example, and the sustainability of estuarine biodiversity
is vital to the ecological and economic health of coastal regions. On the other
hand, estuarine ecosystems are exposed to toxic anthropogenic effluents transported
by rivers from remote and nearby conurbations and industrial and agricultural concerns.
Dehydrogenases and reductases are enzymes of fundamental metabolic
importance that often adopt a specific structure known as the Rossmann
fold. This fold, consisting of a six-strandedb-sheet surrounded bya-helices,
is responsible for coenzyme binding. We have developed a method to iden-tify Rossmann folds and predict their coenzyme specificity (NAD, NADP
or FAD) using only the amino acid sequence as input.
I wrote the first edition of this book more than
20 years ago, and the discoveries in genetics
since then have been phenomenal. The new
knowledge and applications of human genetics to
health and to society have made it even more necessary
that nurses "think genetically" in their practice
and, indeed in their lives. Genetic factors can
be responsible in some way for both direct and
indirect disease causation; for variation that determines
predisposition, susceptibility, and resistance
to disease and also for response to therapeutic
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Salvage radiotherapy for biochemical relapse after complete PSA response following radical prostatectomy: outcome and prognostic factors for patients who have never received hormonal therapy...
Recent reports have demonstrated that interactions between the microtu-bule-associated protein tau and the nonreceptor tyrosine kinase Fyn play a
critical role in mediating synaptic toxicity and neuronal loss in response to
b-amyloid (Ab) in models of Alzheimer’s disease.
HP1286 fromHelicobacter pyloriis among the proteins that play a relevant
role in bacterial colonization and persistence in the stomach. Indeed, it was
demonstrated to be overexpressed under acidic stress conditions, together
with other essential virulence factors. Here we describe its crystal structure,
determined at 2.1 A˚ resolution.
A great deal must still be learnt on the structural features of amyloid
assemblies, particularly prefibrillar aggregates, and the relationship of the
latter with amyloid cytotoxicity. Presently, it is recognized that the popula-tion of unstable, heterogeneous amyloid oligomers and protofibrils is
mainly responsible for amyloid cytotoxicity.
The signal transducers and activators of transcription (STATs) convey sig-nals from the membrane to the nucleus in response to cytokines or growth
factors. STAT3 is activated in response to cytokines involved mostly in cell
proliferation; STAT1 is activated by cytokines, including interferon-c,
involved in defence against pathogens and the inhibition of cell prolifera-tion.
Constitutively expressed human cytochrome P450 2D6 (CYP2D6; EC
22.214.171.124) is responsible for the metabolism of approximately 25% of drugs
in common clinical use. It is widely accepted that CYP2D6 is localized in
the endoplasmic reticulum of cells; however, we have identified this enzyme
in the mitochondria of human liver samples and found that extensive inter-individual variability exists with respect to the level of the mitochondrial