Biological ageing

Xem 1-20 trên 123 kết quả Biological ageing
  • As some of the undergraduate students who participated in this research were undertaking a second undergraduate degree, the age range of the students in this study was quite wide. The youngest was 19 and the oldest 36 years. There were 18 students in the age range that is most likely to coincide with students undertaking their first degree (19 to 23 years), and 22 in the age range more likely to coincide with students undertaking their second degree (24 to 36 years). As the numbers in each of these two groups were almost equally balanced, it was interesting to compare...

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  • Sound emission studies have been launched in the early 1950s. The technology before the mid-1960s, mainly in electronics engineering and materials, enabling rapid development of the method. Currently technical pronounced applied to a number of research areas, both in civil and industrial use.

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  • Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions.

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  • The past century has witnessed a dramatic increase in both life expectancy and the number of older adults. This demographic trend will be greatly accelerated in the next 10 years, as the first wave of baby boomers reaches retirement age. This trend is seen even more strongly among the oldest-old. For example, the 85+ population increased by 38% in the 1990s, from 3.1 million in 1990 to 4.2 million in 2000 (Hetzel & Smith, 2001).

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  • In the second half of 1999, the newly constituted Residential Tenancies Bond Authority’s statistics came on stream. These provided – for the first time in Victoria – virtually a full set of rental statistics, as tenants and landlords are required by Victorian government regulation to pay a bond to the above authority on signing a tenancy agree-ment. The 1999 figures for this study were compiled by striking an average of ‘The Age’ figures for the first half of the calendar year and the tenancy authority’s figures for the latter part of the year.

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  • For a long time, research on developmental issues in the biological and social sciences was mostly concerned with the early parts of life, such as infancy and adolescence. Studies paying full attention to people after they had passed through late adolescence were rare even though we all know that humans continue to develop. The dynamics of adult life can be as forceful and full of transitory states as is life before 20. Individual development is a lifelong process: from the moment of conception to the moment of death.

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  • Oxidative damage to mtDNA is associated with excessive reactive oxygen species production. The mitochondrial common deletion (mtDNA 4977-bp and 4834-bp deletion in humans and rats, respectively) is the most typical and frequent form of mtDNA damage associated with aging and degenera-tive diseases.

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  • To specify the Outpost Network Security Client log cleanup settings on client computers, select the Log Cleanup tab. Select Delete obsolete events to preserve log size to have the Log Cleaner automatically remove outdated log entries from the database or select Keep all records to disable the Log Cleaner. Specify the age in days after which events are considered outdated, the maximum number of the most recent event records to keep in the log and the Log database size limit, a value in megabytes, that determines how large the log database should be allowed to grow. ...

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  • This paper was presented as the first annual John Gerhart Memorial Lecture at the conference of the Africa Genome Initiative held in Cairo in March 2004. In Africa in the Age of Biology, Dr James discusses Africa’s long history of scientific, technological and mathematical enterprise, from tokens of the very earliest counting by humans to the sum of knowledge brought to bear in the construction of the pyramids. But he focuses on the challenges of today, and tomorrow, which he suggests Africa’s leaders and scholars dare not overlook....

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  • The mechanism of age-related decrease of angiogenic potential in myocardium is still unclear. Cardiac microvascular endothelial cells (CMECs) play a key role in cardiac angiogenesis. In this study, using the CMECs which are isolated from young and old hearts, we found that the migration and proliferation capacity of old CMECs were diminished.

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  • Mitochondrial matrix proteins are sensitive to oxidative inactivation, and oxidized proteins are known to accumu-late during ageing. The Lon protease is believed to play an important role in the degradation of oxidized matrix pro-teins such as oxidized aconitase.

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  • A severe challenge to the idea that mitochondrial DNA mutations play a major role in the aging process in mammals is that clear loss-of-function mutations accumulate only to very low levels (under 1% of total) in almost any tissue, even by very old age. Their accumulation is punctate: some cells become nearly devoid of wild-type mitochondrial DNA and exhibit no activity for the partly mitochondrially encoded enzyme cytochrome c oxidase. Such cells accumulate in number with aging, suggesting that they survive indefinitely, which is itself paradoxical....

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  • Prevalence Data from the National Health and Nutrition Examination Surveys (NHANES) show that the percent of the American adult population with obesity (BMI 30) has increased from 14.5% (between 1976 and 1980) to 30.5% (between 1999 and 2000). As many as 64% of U.S. adults ≥20 years of age were overweight (defined as BMI 25) between the years of 1999 and 2000. Extreme obesity (BMI ≥40) has also increased and affects 4.7% of the population. The increasing prevalence of medically significant obesity raises great concern.

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  • The kynurenine pathway of tryptophan catabolism plays an important role in several biological systems affected by aging. We quantified tryptophan and its metabolites kynurenine (KYN), kynurenine acid (KYNA), picolinic acid (PIC) and quinolinic acid (QUIN), and activity of the kynurenine pathway enzymes indoleamine 2,3-dioxygenase

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  • The population of Western countries is aging, and cancer in older aged persons is becoming increasingly common. The management of these neoplasms is a novel problem. Direct information on the outcome of cancer prevention and of cytotoxic chemotherapy in older individuals is scarce, especially for those aged 80 and over, and it is not clear whether the same process should direct medical decisions in younger and older persons. It is reasonable to assume that the benefits of cancer prevention and treatment diminish and the dangers increase with age.

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  • In general, the health status at old age has an important individual and social relevance. The vulnerability is increasing by physiological and morphological changes in the organism and central nervous system during the ageing process. The indicators of physiological health are based on prevalence of disabilities and causes of death. In Germany the main causes of death are circulatory diseases, neoplasms, diseases of respiratory system and diseases of digestive system (Statistisches Bundesamt 2007a; Nolte, Shkolinikov & McKee 2000).

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  • In light of the significant and multifaceted role neuronal, vascular, and inflammatory cells play during degenerative disorders, novel studies that elucidate the role of these cells may greatly further our understanding of disease mechanisms for the development of targeted treatments for a wide spectrum of diseases.

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  • Another study conducted in a kaolin refinery industry produces hazardous by-product such as Al, Fe, and Zn. In kaolin processing, sulphuric acid is used to improve the whitening (Jordao et al., 2002) is discharged to the river waters. This will influence the well being of aquatic organisms that adapted well at close to neutral pH. Also, in order not to affect the colour and whiteness of paper, impurities such as iron oxides is needed to be removed. This can be made through the reduction of Fe(III) to Fe(II) with metallic Zn. Therefore, Zn, Fe, Al are usually present in the discharge....

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  • The five instances of insurance fraud reflected in Table 10 resulted from individu- als who supplied fraudulent information on applications for term life policies. As set forth in FinCEN regulations, 22 an insurance company is not required to report in- stances of suspected insurance fraud unless the company has reason to believe that the false or fraudulent submission of information relates to money laundering or terrorist financing.

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  • From the beginnings of modern science, lakes have fulfilled a focus of attention. Doubtless, this has something to do with the lure that water bodies hold for most of us, as well as for long having been a source of food as well as water. Authors, from Aristotle to Izaak Walton, committed much common knowledge of the freshwater fauna to the formal written record, so it is still a little surprising to realise that the formal study of lakes—limnology (from the Greek word, limnos, a lake)—is scarcely more than a century in age (Forel 1895).

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