Biological engineering research

Xem 1-20 trên 122 kết quả Biological engineering research
  • This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s). comment Deposited research article Gene expression profiles of peripheral blood cells in type 2 diabetes and nephropathy in Asian Indians Paturi V Rao*, Xinfang Lu†, Patrick Pattee†, Mark Turner†, Nandgaonkar Suguna* and Srinivasa R Nagalla† Addresses: *Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences, Hyderabad 500 082, India.

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  • We have come so far so fast in understanding RNA interference (RNAi) and its central role in biology. Rarely has a novel mechanism in molecular genetics had such broad implications, ranging from gene therapy and drug discovery to our very understanding of what the word ‘gene’ means. Every major pharmaceutical company has a substantial effort now in RNAi technology, and among the smaller biotechnology companies RNAi is the mainstay of several, with

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  • Published: 25 August 2004 Genome Biology 2004, 5:343 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/9/343 © 2004 BioMed Central Ltd reports A report on the Keystone Symposium ‘Structural Genomics’, held concurrently with the ‘Frontiers in Structural Biology’ symposium, Snowbird, USA, 13-19 April 2004.

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  • Prokaryotic cyanobacteria express robust circadian (daily) rhythms under the control of a central clock. Recent studies shed light on the mechanisms governing circadian rhythms in cyanobacteria and highlight key differences between prokaryotic and eukaryotic clocks. reports deposited research Rhythmic gene-expression patterns Circadian biological clocks are self-sustained biochemical oscillators. Their properties include an intrinsic time constant of approximately 24 hours, temperature compensation (so that they run...

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  • Volume et al.

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  • From the beginnings of modern science, lakes have fulfilled a focus of attention. Doubtless, this has something to do with the lure that water bodies hold for most of us, as well as for long having been a source of food as well as water. Authors, from Aristotle to Izaak Walton, committed much common knowledge of the freshwater fauna to the formal written record, so it is still a little surprising to realise that the formal study of lakes—limnology (from the Greek word, limnos, a lake)—is scarcely more than a century in age (Forel 1895).

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  • Using the broadest possible definition, a lipid (Greek lipos = fat ) may be defined as a compound of low or intermediate molecular weight (5000), a substantial proportion of which is made up of hydrocarbons. Included are diverse compounds such as fatty acids; soaps; detergents; steroids; mono-, di-, and triacylglycerols; and more complex compounds such as phospholipids, sphingolipids, glycolipids, and lipopolysaccharides.

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  • Collection of reports on forestry research is published in the journal International Forestry topics: Ecological aspects of the floral phenology of the cork-oak (Q suber L): why the Annual and Biennial biotypes appear?

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  • Many drugs have unknown, controversial or multiple mechanisms of action. Four recent ‘chemical genomic’ studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathwaydrug interactions. deposited research The fact that much of modern drug research is target-oriented obscures the long history during which the effects of drugs were discovered prior to identification of their targets. There remain many...

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  • Prediction of Saccharomyces cerevisiae replication origins Adam M Breier*, Sourav Chatterji† and Nicholas R Cozzarelli‡ Addresses: *Graduate Group in Biophysics, University of California-Berkeley, Berkeley, CA 94720-3204, USA. †Department of Computer Science, University of California-Berkeley, Berkeley, CA 94720-3204, USA. ‡Department of Molecular and Cellular Biology, Barker Hall, University of California-Berkeley, Berkeley, CA 94720-3204, USA. Correspondence: Nicholas R Cozzarelli. E-mail: ncozzare@socrates.berkeley.

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  • Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. †Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. ‡Current address: DOE Joint Genome Institute, 2800 Mitchell Drive, Bldg 400, Walnut Creek, CA 94596, USA. Correspondence: Stephanie W Ruby. E-mail: sruby@unm.edu reviews Published: 30 March 2004 Genome Biology 2004, 5:R29 The electronic version of this article is the complete one and can be found online at http://genomebiology.

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  • 30 April 2004 Genome Biology 2004, 5:324 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/324 © 2004 BioMed Central Ltd reviews A report on the 5th annual Advances in Genome Biology and Technology (AGBT) and Automation in DNA Mapping and Sequencing (AMS) meeting, Marco Island, USA, 4-7 February 2004.

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  • This is the first version of this article to be made available publicly. deposited research refereed research .deposited research AS A SERVICE TO THE RESEARCH COMMUNITY, GENOME BIOLOGY PROVIDES A 'PREPRINT' DEPOSITORY TO WHICH ANY ORIGINAL RESEARCH CAN BE SUBMITTED AND WHICH ALL INDIVIDUALS CAN ACCESS interactions FREE OF CHARGE. ANY ARTICLE CAN BE SUBMITTED BY AUTHORS, WHO HAVE SOLE RESPONSIBILITY FOR

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  • Aidan Budd*, Stephanie Blandin*, Elena A Levashina† and Toby J Gibson* Addresses: *European Molecular Biology Laboratory, 69012 Heidelberg, Germany. †UPR 9022 du CNRS, IBMC, rue René Descartes, F-67087 Strasbourg CEDEX, France. Correspondence: Toby J Gibson. E-mail: toby.gibson@embl.de reviews Published: 26 May 2004 Genome Biology 2004, 5:R38 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/R38 Received: 20 February 2004 Revised: 2 April 2004 Accepted: 8 April 2004 © 2004 Budd et al.

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  • The death of Francis Crick, who succumbed to colon cancer on 28 July at the age of 88, does more than mark the end of one of the most distinguished, and influential, scientific careers of the last century. It also helps mark the end of an era: the remarkable era when biology was transformed from a descriptive, largely organism-based science into a molecular one. Now we are living through another period of transformation, as genomics allied with molecular biology changes the subject into one that is more quantitative, more dependent on computational and engineering tools -...

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  • Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA. reports deposited research A common mechanism for class-switch recombination and somatic hypermutation In all cells, high-fidelity pathways repair DNA to maintain the integrity of the genome. A handful

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  • A recent, genome-wide study shows that the transcriptional program underlying leaf senescence is active and complex, reflecting the activation of more than 2,000 genes in Arabidopsis, with gene products involved in a broad spectrum of regulatory, biochemical and cellular events. reports deposited research Aging and senescence in plants Senescence, aging and death - conceived of in the past as inevitable, negative processes - are now considered an integral part of differentiation and development. Leaf senescence is one of the most conspicuous...

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  • The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes, and Caenorhabditis elegans. Caveolins can serve as protein markers of caveolae (‘little caves’), invaginations in the plasma membrane 50-100 nanometers in

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  • For decades, researchers have focused most of their attention on protein-coding genes and proteins. With the completion of the human and mouse genomes and the accumulation of data on the mammalian transcriptome, the focus now shifts to non-coding DNA sequences, RNA-coding genes

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  • Improvements in the fields of membrane-protein molecular biology and biochemistry, technical advances in structural data collection and processing, and the availability of numerous sequenced genomes have paved the way for membrane-protein structural genomics efforts. There has been significant recent progress, but various issues essential for

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