Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The impact of sample storage time on estimates of association in biomarker discovery studies...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
The workshop "Stratification biomarkers in personalised medicine" that was held at the European
Commission in Brussels on 10th
June 2010 brought together experts from different fields
and perspectives in order to stimulate an open discussion about the evolution of this rapidly
expanding area, in which biomarkers are used to adapt therapies to the characteristics of patient
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery...
Today, cancer research is focused on determining how genome and proteome level
information may be useful as tools in prevention, diagnosis, and prognosis. The
development of “omics” technologies, such as proteomics and transcriptomics has
opened new research areas for scientists working on cancer research.
Detection of cancer at early stages that can be treated through surgery is a
difficult task. One methodology for cancer biomarker discovery exploits
the fact that glycoproteins produced by cancer cells have altered glycan
structures, although the proteins themselves are common, ubiquitous,
abundant, and familiar.
The impact of biomarkers in present day health care system, health management and
healthy life is enormous. Clinicians need them for diagnosis, prognosis, effect of
therapeutic intervention, and most importantly, for early detection of a disease.
Pharmaceutical industries need them for new drug discovery and drug efficiency test.
Regulatory authorities need them for testing toxicity and environmental impact.
Epidemiologists need them for population screening and risk factor determination.
In recent years, completion of the sequencing of the human genome as well as the
genomes of dozens of other organisms and subsequent development of tools for comprehensive
analysis of other cellular constituents have revolutionized biology. These new
technologies, referred to broadly as “genomics,” have integrated biologic sciences with
information sciences and engineering.
Serum prostate specific antigen (PSA) is the only biomarker routinely used for the early
detection of prostate cancer, but it is not a perfect test. Although PSA is highly specific for
prostate, an elevated level is not specific for cancer, being increased in benign hyperplasia
and prostatitis (Pungalia, 2006; Bozeman, 2002). Consequently, the majority of men with
an increased serum PSA do not have prostate cancer and thus undergo unnecessary
In his opening address to the conference, Jon wood, who coordinates the
research programme at the Institute, traced the origins of the conference to a
series of exploratory conversations on the relationship between archaeology
and contemporary art with independent curator Katy rochester. From the
outset, wood, rochester and their colleagues in leeds sought proposals from
archaeologists who were interested in sculpture and in sharing new ideas
with sculpture historians.
Nutrigenomics, proteomics and metabolomics are three
new disciplines that will contribute to the rapid development
of functional foods. Bioinformatics is a new tool that uses
computer database technology to integrate data from
multiple, and sometimes disparate, disciplines. Already
these disciplines and tools have improved our understanding
of food science and human nutrition. Discoveries in genetics
make it possible to understand the effects of nutrients in
processes at the molecular level in the body and also the
variable effects of dietary components on each individual.
This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s).
Deposited research article
Gene expression profiles of peripheral blood cells in type 2 diabetes and nephropathy in Asian Indians
Paturi V Rao*, Xinfang Lu†, Patrick Pattee†, Mark Turner†, Nandgaonkar Suguna* and Srinivasa R Nagalla†
Addresses: *Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences, Hyderabad 500 082, India.
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein...
Colorectal cancer (CRC) is a major public health issue worldwide, and
novel tumor markers may contribute to its efficient management by helping
in early detection, prognosis or surveillance of disease. The aim of our
study was to identify new serum biomarkers for CRC, and we followed a
phased biomarker discovery and validation process to obtain an accurate
preliminary assessment of potential clinical utility.
Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field.
Recent advances in clinical proteomics have propelled us into an exciting period of discovery of
new cancer biomarkers, although the available proteomic technologies have their limitations. The
principles of proteomic technology require stringent guidelines for the collection of clinical material,
the application of analytical techniques, and for our interpretation of the data.
In this review, we present an overview of the serum tumor markers in current use.