Biomarker research

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  • Historically, most cancer research has been conducted through small independent projects initiated by individual investigators with relatively small research groups. Such research is driven by focused hypotheses addressing specific biological questions. There will always be a need for this traditional approach to research; in recent years, however, it has also become more feasible to undertake projects on a broader and larger scale, thereby developing extensive pools of data and research tools that can facilitate those more conventional efforts....

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  • This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s). comment Deposited research article Gene expression profiles of peripheral blood cells in type 2 diabetes and nephropathy in Asian Indians Paturi V Rao*, Xinfang Lu†, Patrick Pattee†, Mark Turner†, Nandgaonkar Suguna* and Srinivasa R Nagalla† Addresses: *Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences, Hyderabad 500 082, India.

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  • The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical issue. Methods: A total of 16 healthy volunteers and 45 patients with chronic hepatitis C virus (HCV) were enrolled (F0: n = 16, F1: n = 7, F2: n = 17, F3: n = 8 and F4: n = 13, according to the METAVIR classification). Three serum samples of each fibrotic stage were analyzed by two-dimension difference gel electrophoresis (2D-DIGE). The differential proteins were identified by...

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  • Detection of cancer at early stages that can be treated through surgery is a difficult task. One methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by cancer cells have altered glycan structures, although the proteins themselves are common, ubiquitous, abundant, and familiar.

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  • Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field.

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  • Exploring for oil and gas Traps is one of the main aim of the “Crude Oil Exploration in the World” which represents an important part of the Treatise of Petroleum Geology and Geochemistry in the world. We have chosen eleven distinguished papers from the entire submitted researches around the world in the field of oil and gas exploration and environmental application from the world. These researches represent a guide to the petroleum geologists and geochemists all over the world.

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  • This book is unique among its peers as it offers a broad international perspective and discusses practice approaches from around the globe. In addition, key elements of emergency medicine practice are covered for the reader discussing historical and cutting edge approaches and their scientific basis. The chapters that make up this textbook should be of interest to any reader who treats or is interested in the treatment of the emergency patient whether the patient is located in the pre-hospital, emergency department or in-hospital settings....

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  • More recently, Cox and Fisher (2009) analyzed the titles of contemporary romance novels to determine if their popularity might be related to evolutionary themes that would be expected to have widespread appeal when it comes to some of the unique and recurrent reproductive issues that women confront. The five most common words featured in romance novel titles were love, bride, baby, man, and marriage, in that order. Common themes extracted from these titles included commitment, reproduction, masculine/high ranking suitors, and resources.

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  • Ankylosing Spondylitis (AS) was first described possibly at the end of the XVII century by Buckley (1931) and Connor, but it was only recognized after the radiologic descriptions of Bechterew, Strumpell and Marie, during the XIX century. In 1964 the American Rheumatism Association classified AS as a distinct disease. About forty years ago (1973), Schlosstein and Brewerton published simultaneously but independently the association of AS with the Class I allele B*27.

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  • Today, cancer research is focused on determining how genome and proteome level information may be useful as tools in prevention, diagnosis, and prognosis. The development of “omics” technologies, such as proteomics and transcriptomics has opened new research areas for scientists working on cancer research.

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  • Three features taken together distinguish federal funds from other money market instruments. First, they are short-term borrowings of immediately available money—funds which can be transferred between depository institutions within a single business day. In 1991, nearly three-quarters of federal funds were overnight borrowings. The remainder were longer maturity borrowings known as term federal funds. Second, federal funds can be borrowed by only those depository institutions that are required by the Monetary Control Act of 1980 to hold reserves with Federal Reserve Banks.

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  • In his opening address to the conference, Jon wood, who coordinates the research programme at the Institute, traced the origins of the conference to a series of exploratory conversations on the relationship between archaeology and contemporary art with independent curator Katy rochester. From the outset, wood, rochester and their colleagues in leeds sought proposals from archaeologists who were interested in sculpture and in sharing new ideas with sculpture historians.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study...

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  • Traditional Chinese medicine, including herbal medicine and acupuncture, as one of the most important parts in complementary and alternative medicine (CAM). Recent research showed that complementary and alternative medicine could contribute to primary health care. Traditional Chinese medicine(TCM) has evolved a system that aims to cure illness by penetrating the skin at specific points. This system is called acupuncture, derived from the Latin words "acus" and "punctura" meaning "needle" and "pricked", respectively....

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  • Aleksandra Klemba1,2, Magdalena Kowalewska3, Wojciech Kukwa4, Katarzyna Tonska1, Aleksandra Szybinska5, Malgorzata Mossakowska5, Anna Scinska4, Paweł Golik1,6, Kamil Koper1, Jakub Radziszewski7, Andrzej Kukwa4, Anna M Czarnecka1,2*, Ewa Bartnik1,6 Abstract Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a diagnostic tool in oncology.

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  • Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression. methods We performed intravascular ultrasonography in 502 patients with angiographically documented coronary disease. Patients were randomly assigned to receive moderate treatment (40 mg of pravastatin orally per day) or intensive treatment (80 mg of atorvastatin orally per day)....

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  • Our study is part of a recent literature that investigates the asset pricing impact of behavioral biases documented in psychology research. This literature, which has expanded significantly over the last decade, is comprehensively reviewed by Hirshleifer (2001) and Shiller (2000). The strand of the literature closest to this paper investigates the effect of investor mood on asset prices. The two principal approaches in this work link returns either to a single event or to a continuous variable that impacts mood. ...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Clinical use of biomarkers of survival in pulmonary fibrosis...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers...

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