Biophysical properties

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  • The study of electromagnetic radiation (EM) can be divided into two distinct areas: full solution of Maxwell's Equations relevant to the specific boundary conditions in a special general case and into application of EM radiation that results in modern life e.g. medicine, telecommunication, electromagnetic compatibility (EMC) etc. The reader should have a specific scientific background and must be familiar with the fundamental ideas of EM theory for the first area. Basic understanding of applying the radiation techniques in modern life is needed for the second.

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  • Aegyptin is a 30 kDa mosquito salivary gland protein that binds to collagen and inhibits platelet aggregation. We have studied the biophysical properties of aegyptin and its mechanism of action. Light-scattering plot showed that aegyptin has an elongated monomeric form, which explains the apparent molecular mass of 110 kDa estimated by gel-filtration chromatography.

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  • K-Ras is a small G-protein, localized mainly at the inner leaflet of the plasma membrane. The membrane targeting signal of this protein consists of a polybasic C-terminal sequence of six contiguous lysines and a farnesyl-ated cysteine. Results from biophysical studies in model systems suggest that hydrophobic and electrostatic interactions are responsible for the membrane binding properties of K-Ras.

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  • Mutations in the proteina-tropomyosin (Tm) can cause a disease known as familial hypertrophic cardiomyopathy. In order to understand how such mutations lead to protein dysfunction, three point mutations were introduced into cDNA encoding the human skeletal tropomyosin, and the recombinant Tms were produced at high levels in the yeast Pichia pastoris. Two mutations (A63V and K70T) were located in theN-terminal regionofTmandone (E180G)was located close to the calcium-dependent troponin T binding domain....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptases...

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  • Electrochemical systems—e.g., batteries, capacitors, and fuel cells—are an integral part of modern technology. Electrochemical techniques, especially potentiometry and voltammetry, are indispensable for state-of-the-art analysis, and also for fundamental studies of the properties of solution species and solid phases and materials. Last, but not least, electrochemical concepts for understanding charge transfer reactions entered the fields of biochemistry and biophysics.

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