Blood compatibility

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  • The second edition of Safety Evaluation of Medical Devices continues to focus on the objective of the first edition—to serve as a single-volume practical guide for those who are responsible for or concerned with ensuring safety in the use and manufacture of medical devices. It benefits from recognition of the limitations and shortcomings of the previous edition, and also reflects the changes in regulations, science, and the marketplace.

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  • A new polymer "heparinanalogy" has been synthesized from vinylsaccharide compounds. This Polymer contains O-sulfat-, N-sulfat-, carboxyl- and hydroxyl groups, degree of sulfation (DS) per basic molecule unit is 2,3. The tests of bioactivity confirm that synthesized polymer is blood compatible and antithrombin.

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  • Pure Red Cell Aplasia: Treatment History, physical examination, and routine laboratory studies may disclose an underlying disease or a suspect drug exposure. Thymoma should be sought by radiographic procedures. Tumor excision is indicated, but anemia does not necessarily improve with surgery. The diagnosis of parvovirus infection requires detection of viral DNA sequences in the blood (IgG and IgM antibodies are commonly absent). The presence of erythroid colonies has been considered predictive of response to immunosuppressive therapy in idiopathic PRCA.

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