Blood transfusion is a field where there has been, and continue to be, significant advances
in science, technology and most particularly governance. The aim of this book is to provide
students of allied medical sciences, medicine and transfusion practitioners with a comprehensive
overview of both the scientific and managerial aspects of blood transfusion. The book
is intended to equip biomedical, clinical and allied medical professionals with practical tools
to allow for an informed practice in the field of blood transfusion management....
Blood Transfusion Therapy in High Risk Surgical Patients 25 João Manoel Silva Junior and Alberto Mendonça P. Ferreira Blood Transfusion Practices in Major Orthopaedic Surgery 35 Saqeb B. Mirza, Sukhmeet S. Panesar and Douglas G. Dunlop Transfusion Reduction in Orthopedic Surgery 61 Ruud H.G.P. van Erve and Alexander C. Wiekenkamp Scope of Blood Transfusion in Obstetrics 83 Subhayu Bandyopadhyay Uterine Atony: Management Strategies 97 Pei Shan Lim, Mohamad Nasir Shafiee, Nirmala Chandralega Kampan,...
The art of fluid administration and haemodynamic support is one of
the most challenging aspects of current critical care practice. Although
more than half the patients in intensive care units (ICU) receive blood
transfusions there is little in the way of data to guide decisions on when
to give transfusions. The American College of Physicians, among others,
has published a transfusion algorithm.1 However, this is based, not on
controlled clinical trials, but on expert opinion. Despite these guidelines,
transfusion practice varies widely....
The first edition of Blood Transfusion in Clinical
Medicine was published in 1951, at a time when the
subject was, if not in its infancy, certainly in its very
early childhood. Transfusions were given for the treatment
of acute blood loss or for the relief of chronic
anaemia. Platelet and leucocyte transfusions were not
attempted and plasma fractions were not available.
Pyruvate Kinase Deficiency: Treatment Management of PK deficiency is mainly supportive. In view of the marked increase in red cell turnover, oral folic acid supplements should be given constantly. Blood transfusion should be used as necessary, and iron chelation may have to be added if the blood transfusion requirement is high enough to cause iron overload. In these patients, who have more severe disease, splenectomy may be beneficial.
Alternatives to Transfusion Alternatives to allogeneic blood transfusions that avoid homologous donor exposures with attendant immunologic and infectious risks remain attractive. Autologous blood is the best option when transfusion is anticipated. However, the cost:benefit ratio of autologous transfusion remains high. No transfusion is a zerorisk event; clerical errors and bacterial contamination remain potential complications even with autologous transfusions.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Endothelial Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports
The benefit-to-risk ratio of blood products needs constant
evaluation. Blood products, as therapeutic agents,
have had the test of time but lack the evidence we expect
from other medicinals. Blood, an organ, is used as
a pharmaceutical agent by the medical profession, due to
the achievements in collection, processing, banking, and
distribution. The fact that the most common risk of blood
transfusion isblood delivery error supports the notion that
blood is handled as a pharmaceutical agent.
As with the first edition, the primary purpose of this
book is to describe human blood group antigens and
their inheritance, the antibodies that define them, the
structure and functions of the red cell membrane
macromolecules that carry them, and the genes that
encode them or control their biosynthesis. In addition,
this book provides information on the clinical relevance
of blood groups and on the importance of blood
group antibodies in transfusion medicine in particular.
Harrison's Internal Medicine Chapter 107. Transfusion Biology and Therapy
Blood Group Antigens and Antibodies The study of red blood cell (RBC) antigens and antibodies forms the foundation of transfusion medicine. Serologic studies initially characterized these antigens, but now the molecular composition and structure of many are known. Antigens, either carbohydrate or protein, are assigned to a blood group system based on the structure and similarity of the determinant epitopes.
Peripheral blood smear from a 5-year-old G6PD-deficient boy with acute favism.
A very small minority of subjects with G6PD deficiency have CNSHA of variable severity. The patient is always a male, usually with a history of NNJ, who may present with anemia or unexplained jaundice, or because of gallstones later in life. The spleen may be enlarged. The severity of anemia ranges from borderline to transfusion-dependent. The anemia is usually normo-macrocytic, with
reticulocytosis. Bilirubin and LDH are increased.
Severe acute AIHA can be a medical emergency. The immediate treatment almost invariably includes transfusion of red cells. This may pose a special problem because if the antibody involved is "unspecific," all the blood units crossmatched will be incompatible. In these cases it is often correct, paradoxically, to transfuse incompatible blood, the rationale being that the transfused red cells will be destroyed no less but no more than the patient's own red cells, and in the meantime the patient stays alive.