Both struc-turally and functionally

Xem 1-20 trên 163 kết quả Both struc-turally and functionally
  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments

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  • Antifreeze proteins (AFPs) designate a class of proteins that are able tobind toand inhibit the growthofmacromolecular ice. These proteins have been characterized froma variety of organisms. Recently, the structures ofAFPs fromthe spruce budworm (Choristoneura fumiferana) and the yellow meal-worm (Tenebrio molitor) have been determined by NMR and X-ray crystallography. Despite nonhomologous sequences, both proteins were shown to consist ofb-helices.

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  • The transforming growth factorb(TGF-b) superfamily includes bone mor-phogenetic proteins, activins and TGF-bsensu stricto (s.s). These ligands, which transduce their signal through a heteromeric complex of type I and type II receptors, have been shown to play a key role in numerous biologi-cal processes including early embryonic development in both deuterostomes and ecdyzozoans.

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  • Engineering and Food for the third millenniumthat is compliant with the requirements of globalization and new technologies, is one of the most significant additions to the Food Preservation Technology Series. This bookis the result of a tremendous effort by the authors, the publisher and editors to put together, as never before, a comprehensive overview on what is current in food engineering.

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  • Large lakes are important because of their size and ecological distinctiveness, as well as their economic and cultural value. Optimal management of them requires a proper understanding of anthropogenic impacts, both on the lake ecosystems, as such and on the services they provide for society. The specific structural and functional properties of large lakes, e.g. morphology, hydrography, biogeochemical cycles, and food-web structure, are all directly related to their size.

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  • Human serum albumin (HSA) exists in both reduced and oxidized forms, and the percentage of oxidized albumin increases in several diseases. How-ever, little is known regarding the pathophysiological significance of oxida-tion due to poor characterization of the precise structural and functional properties of oxidized HSA.

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  • The divalent metal transporter (DMT1) is a 12-transmem-brane domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues. The transmembrane domain 4 (TM4) of DMT1 has been shown to be crucial for its biological function. Here we report the 3D structure and topology of the DMT1-TM4 peptide by NMR spectroscopy with simulated annealing calculations in membrane-mimetic environments, e.g. 2,2,2-trifluoroethanol and SDS micelles.

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  • Summative evaluation focusses on programs that are already underway or completed. It investigates the effects of the program, both intended and unintended. It seeks to answer the questions “Did the program make a difference?”(impact evaluation) and “Did the program meet its stated goals and objectives?”(outcome evaluation). In its most rigorous form the design of an outcome evaluation can become very complex in order to rule out any other plausible explanations for the results.

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  • This book describes the structure of the classical groups, meaning general linear groups, sympletics groups, and orthogonal groups, both over general is a systematic development of the theory of building and BN- pairs, both spherical and affine , white the other half is ilustrations by and applications the classical groups.

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  • The Sixth Edition of Dr. Haines's best-selling neuroanatomy atlas features a stronger clinical emphasis, with significantly expanded clinical information and correlations. More than 110 new images--including MRI, CT, MR angiography, color line drawings, and brain specimens--highlight anatomical-clinical correlations. Internal spinal cord and brainstem morphology are presented in a new format that shows images in both anatomical and clinical orientations, correlating this anatomy exactly with how the brain and its functional systems are viewed in the clinical setting.

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  • PLANT CELLS, UNLIKE ANIMAL CELLS, are surrounded by a relatively thin but mechanically strong cell wall. This wall consists of a complex mixture of polysaccharides and other polymers that are secreted by the cell and are assembled into an organized network linked together by both covalent and noncovalent bonds. Plant cell walls also contain structural proteins, enzymes, phenolic polymers, and other materials that modify the wall’s physical and chemical characteristics.

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  • Among the elements of the conferences that have to do with the elderly, the following are noted: education about the main health problems and the methods to prevent them; promotion of food supplies and adequate nutrition; supply of appropriate drinking water and basic sanitation; immunization against major infectious diseases; prevention and control of endemic diseases; appropriate treatment of common diseases and accident consequences and availability of essential medication, in addition to social resources, such as social groups, universities open to the seniors and awareness about the ph...

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  • In particular, note that there are two potential sources of timing-related fund returns that are correlated with public information. The first, predictable fund risk-loadings, may be due to changing stock-level risk loadings, to flows into the funds, or to manager timing of the benchmarks. The second exploits predictability in the benchmark returns themselves. Such predictability is captured through the time-series regression in Eq. (2). Because both of these timing components are assumed to be easily replicated by an investor, we do not consider them to be based on manager ‘‘skill.

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  • Human hypoxanthine-guanine phosphoribosyltransferase (HPRT) (EC catalyzes the conversion of hypoxanthine and guanine to their respective nucleoside monophosphates. Human HPRT deficiency as a result of genetic mutations is linked to both Lesch–Nyhan disease and gout. In the present study, we have characterized phosphoribosyltransferase domain containing protein 1 (PRTFDC1), a human HPRT homolog of unknown function.

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  • Hierarchical phrase-based models are attractive because they provide a consistent framework within which to characterize both local and long-distance reorderings, but they also make it dif cult to distinguish many implausible reorderings from those that are linguistically plausible. Rather than appealing to annotationdriven syntactic modeling, we address this problem by observing the in uential role of function words in determining syntactic structure, and introducing soft constraints on function word relationships as part of a standard log-linear hierarchical phrase-based model. ...

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  • PolC is one of two essential replicative DNA polymerases inBacillus subtil-is and other Gram-positive bacteria. The 3D structure of PolC has recently been solved, yet it lacks the N-terminal region. For this PolC region of 230 residues, both the structure and function are unknown.

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  • Activation of the superoxide-producing NADPH oxidase Nox1 requires both the organizer protein Noxo1 and the activator protein Noxa1. Here we describe an alternative splicing form of Noxo1, Noxo1c, which is expressed in the testis and fetal brain.

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  • Recent studies on the analysis of intonational function examine a r a n ~ of materials from cue phrases in monologue (Litman and Hirschberg, 1990) and dialogue (Hirschberg and Litman, 1987; Hockey, 1991) to longer utterances in both monologue and dialogue (McLemore, 1991). Results match specific intonational tunes to certain discourse functions which are more or less well defined. Although these results make a convincing case that intonation does signal a change in discourse structure, the specification of discourse function remains vague. ...

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  • We report the cloning and functional charaterization of the full-length cDNA and gene encoding a Toxoplasma gondii DNA repair enzyme designated TgDRE. The gene is composed of three exons separated by two introns of 780 and 630 bp, and encodes a protein with a predicted molecular mass of 49.6 kDa. The native TgDRE protein, with a molecular mass of 60 kDa, is only detected in the virulent tachyzoite stage of T. gondii. However, the transcript is present in both asexual parasite stages, virulent tachyzoite and avirulent encysted bradyzoite. ...

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  • Dual-specificity phosphatases (DSPs) constitute a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylates phospho-Tyr, phos-pho-Ser and nonproteinaceous substrates. DSPs are involved in the regula-tion of both developmental and postnatal essential processes, such as early embryogenesis, placental development and immune responses.

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