There have been a significant number of advances
in the field of cancer research since the
first edition of Cancer Biology, which was published
in 1981. These include advances in defining
the genetic and phenotypic changes in cancer
cells, the genetic susceptibility to cancer, molecular
imaging to detect smaller and smaller tumors,
the regulation of gene expression, and the
‘‘-omics’’ techniquesofgenomics, proteomics,and
metabolomics, among others.
In its fifth edition, Cancer Medicine has been named eponymously to honor its founding
editors James F. Holland and Emil Frei III, two giants of medical oncology. The Holland-Frei
Cancer Medicine reflects their dedication to innovative, comprehensive, and multidisciplinary
care of cancer patients, as well as their belief in the importance of grounding such care in a more
fundamental understanding of cancer biology. It is to their vision and the example that they have
established over the last four decades that this book is dedicated.
In the past 15 years, molecular biologists and geneticists have uncovered
some of the most basic mechanisms by means of which normal stem cells
in a certain organ or tissue develop into cancerous tumors. This biological
knowledge serves as a basis for various models of carcinogenesis.
The spermine analogue N1,N11-diethylnorspermine (DENSPM) eﬃciently depletes the cellular pools of putrescine, spermidine and spermine by down-regulating the activity of the polyamine biosynthetic enzymes and up-regulating the activity of the catabolic enzyme spermidine/ spermine N1-acetyltransferase (SSAT). In the breast cancer cell line L56Br-C1, treatment with 10 lM DENSPM induced SSAT activity 60 and 240-fold at 24 and 48 h after seeding, respectively, which resulted in polyamine depletion. ...
We investigated the role ofb3Gal-T5, a member of the
b1,3galactosyltransferase (b1,3Gal-T) family, in cancer-associated glycosylation, focusing on the expression of
sialyl-Lewis a (sLe
, the epitope of CA19.9 antigen), poly
N-acetyllactosamines, and sialyl-Lewis x (sLe
clone permanently expressing an antisense fragment of
b3Gal-T5 was obtained from the human pancreas adeno-carcinoma cell line BxPC3 and characterized. Bothb1,3Gal-T activity and sLe
expression are dramatically impaired in
the clone. ...
HIC1(hypermethylated in cancer 1) is a transcriptional
repressor containing fiveKru¨ppel-likeC2H2zinc fingers and
an N-terminal dimerization and autonomous repression
domain called BTB/POZ. Here, we demonstrate that full-length HIC1 proteins are modified both in vivo andin vitro
with O-linkedN-acetylglucosamine (O-GlcNAc). This is
a highly dynamic glycosylation found within the cytosolic
and the nuclear compartments of eukaryotes. Analysis of
H]Gal-labeled tryptic peptides indicates that HIC1 has
three major sites forO-GlcNAc glycosylation....
Cancer can be defined as a disease in which a group of abnormal cells grow uncontrollably by disregarding the normal rules of cell division. Normal cells are constantly subject to signals that dictate whether the cell should divide, differentiate into another cell or die. Cancer cells develop a degree of autonomy from these signals, resulting in uncontrolled growth and proliferation. If this proliferation is allowed to continue and spread, it can be fatal. In fact, almost 90% of cancer-related deaths are due to tumour spreading – a process called metastasis....
Tumor protein D52 (TPD52) is a protein found to be overexpressed in
prostate and breast cancer due to gene amplification. However, its physio-logical function remains under investigation. In the present study, we inves-tigated the response of the LNCaP human prostate carcinoma cell line to
deregulation of TPD52 expression.
The population of Western countries is aging, and cancer in older
aged persons is becoming increasingly common. The management of these
neoplasms is a novel problem. Direct information on the outcome of cancer
prevention and of cytotoxic chemotherapy in older individuals is scarce,
especially for those aged 80 and over, and it is not clear whether the same
process should direct medical decisions in younger and older persons. It is
reasonable to assume that the benefits of cancer prevention and treatment
diminish and the dangers increase with age.
Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers.
This volume is the first book-length survey of caveolae and lipid rafts. Interest has
developed rapidly in the role of these surface microdomains in such diverse fields
as transmembrane signaling, cell locomotion, vascular relaxation, senescence, and
the uptake and exit from cells of viruses and bacteria. Individual chapters in this
volume cover areas as diverse as the forces that induce and maintain membrane
invaginations, and the clinical relevance of multiprotein complexes at the cell surface,
defects in which are associated with cancer, and Alzheimer’s and prion-dependent
There is growing evidence on the importance of studies focusing on mechanisms and
strategies leading to cancer prevention. The plethora of approaches include regulation
of oxidative stress using antioxidant therapies, carefully balanced diets and living
habits, epidemiological evidence and molecular approaches on the role of key
biological molecules such as antioxidant enzymes, vitamins, proteins and naturally
occurring free radical scavengers as well as controversial results and clinical
applications. These are some of the topics that this book highlights.
Clinical course of CLL is variable. Recently, progress has been made in the identification of
biological markers that could predict disease progression. Particularly, the expression of
unmutated Ig genes, some cytogenetic abnormalities like 17p and 11q deletions and the
expression of the zeta-associated protein 70 (ZAP-70) are associated to a poor prognosis.
Over the past 20 years, technological advances in molecular biology have
proven invaluable to the understanding of the pathogenesis of human cancer.
The application of molecular technology to the study of cancer has not only
led to advances in tumor diagnosis, but has also provided markers for the
assessment of prognosis and disease progression. The aim of Molecular Analysis
of Cancer is to provide a comprehensive collection of the most up-to-date
techniques for the detection of molecular changes in human cancer.
Cell culture is practiced extensively throughout the world today. The techniques
required to allow cells to grow and be maintained outside the body have been developed
throughout the 20th century. In the 50 years since the publication of the first
human cancer cell line, HeLa (1), thousands of cell lines representing most of the
spectrum of human cancer have been derived. These have provided tools to study in
depth the biochemistry and molecular biology associated with individual cancer types
and have helped enormously in our understanding of normal as well as cancer cell
Pancreatic cancer is one of the most fatal human malignancies with extremely poor
prognosis making it the fourth leading cause of cancer-related deaths in the United
States. The molecular mechanisms of pancreatic carcinogenesis are not well
understood. The major focus of these two books is towards the understanding of the
basic biology of pancreatic carcinogenesis, identification of newer molecular targets
and the development of adjuvant and neoadjuvant therapies.
Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology.
Highlights in Skincancer is a companion handbook published expressly for all the practitionners who are interested in skin cancers: medical oncologists and dermatologists but also residents, general practitionners, surgeons, plastic surgeons. The book is designed to teach new aspects of skincancers in the context of practical clinical settings. Each topic is an expert view of a specific skincancer field.
Harrison's Internal Medicine Chapter 80. Cancer Cell Biology and Angiogenesis
Cancer Cell Biology and Angiogenesis: Introduction Two characteristic features define a cancer: unregulated cell growth and tissue invasion/metastasis. Unregulated cell growth without invasion is a feature of benign neoplasms, or new growths. Cancer is a synonym for malignant neoplasm. Cancers of epithelial tissues are called carcinomas; cancers of nonepithelial (mesenchymal) tissues are called sarcomas. Cancers arising from hematopoietic or lymphoid cells are called leukemias or lymphomas.