Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics...
The taxanes include paclitaxel and docetaxel. These agents differ from the vinca alkaloids in that the taxanes stabilize microtubules against depolymerization. The "stabilized" microtubules function abnormally and are not able to undergo the normal dynamic changes of microtubule structure and function necessary for cell cycle completion. Taxanes are among the most broadly active antineoplastic agents for use in solid tumors, with evidence of activity in ovarian cancer, breast cancer, Kaposi's sarcoma, and lung tumors.
Epidermal growth factor receptor (EGFR) and its three related proteins
(the ERBB family) are receptor tyrosine kinases that play essential roles in
both normal physiological conditions and cancerous conditions. Upon
binding its ligands, dynamic conformational changes occur in both extra-
A hallmark ofa-crystallin-type small heat shock proteins
(sHsps) is their highly dynamic oligomeric structure which
promotes intermolecular interactions involved in subunit
exchange and substrate binding (chaperone-like activity).
We studied the oligomeric features of two classes of bacterial
sHsps by size exclusion chromatography and nanoelectro-spray mass spectrometry.Proteins of both classes formed
large complexes that rapidly dissociated upon dilution and
at physiologically relevant heat shock temperatures....
HIC1(hypermethylated in cancer 1) is a transcriptional
repressor containing fiveKru¨ppel-likeC2H2zinc fingers and
an N-terminal dimerization and autonomous repression
domain called BTB/POZ. Here, we demonstrate that full-length HIC1 proteins are modified both in vivo andin vitro
with O-linkedN-acetylglucosamine (O-GlcNAc). This is
a highly dynamic glycosylation found within the cytosolic
and the nuclear compartments of eukaryotes. Analysis of
H]Gal-labeled tryptic peptides indicates that HIC1 has
three major sites forO-GlcNAc glycosylation....
Recent years have witnessed high levels of activity in identifying enzyme systems that catalyse H-transfer by quantum tunneling. Rather than being restricted to a small number of speciﬁc enzymes as perceived initially, it has now become an accepted mechanism for H-transfer in a growing number of enzymes. Furthermore, H-tunneling is driven by the thermally induced dynamics of the enzyme. In some of those enzymes that break stable C–H bonds the reaction proceeds purely by quantum tunneling, without the need to partially ascend the barrier.
One of the important ways in which this guidance is used reflects a
greater concern with implementation. Recommendations from the
original breast guidance were incorporated into the NHS cancer
standards for both England6
These standards have in turn
been used to help improve services in various ways (including
national peer review in England), and have informed reviews of
cancer services carried out by the Commission for Health
Improvement and Audit Commission.
The low affinity of peptide nucleic acid (PNA) to hybridize with DNA in
the presence of a mismatch endows PNA with a high degree of discriminat-ory capacity that has been exploited in therapeutics for the selective inhibi-tion of the expression of point-mutated genes. To obtain a structural basis
for this intriguing property, molecular dynamics simulations are carried
out on PNAÆDNA duplexes formed at the Ki-ras proto-oncogene, compri-sing the point-mutated (GAT), and the corresponding wild-type (GGT)
codon 12. ...
Computed tomography (CT) is the mainstay of
cancer imaging outside of the central nervous
system. Advances in multidetector CT (MDCT)
technology have had a profound impact on its diagnostic
capabilities. Such techniques as multiphase, single breath-hold
imaging, CT angiography (CTA), volume rendering and
virtual colonography owe their success to the development of
multidetector arrays with continuously moving gantries.
The presence or absence of diseases is strongly associated with individual health but did
not fulfil the multidimensional concept of health. Health is characterised by dynamic and
multi-factorial influences on the physical, psychological and social functioning of an
individual. On the one hand, an objective health status includes the set of diagnosed
physiological and psychological diseases of an individual.
Cells respond to environmental cues through a complex and dynamic
network of signaling pathways that normally maintain a critical balance
between cellular proliferation, differentiation, senescence, and death. One
current research challenge is to identify those aberrations in signal transduction
that directly contribute to a loss of this division-limited equilibrium and
the progression to malignant transformation. The study of cell-signaling molecules
in this context is a central component of cancer research.
As seen in Table 7, both Planned Parenthood and other WHP clinics typically offer a
comprehensive range of contraceptive methods. The methods include oral contraceptives (the
Pill) as well as long-acting reversible contraceptives (LARCs) such as intrauterine devices
(IUDs), implants (e.g., Implanon), or injectables (e.g., Depo-Provera). LARCs are particularly
important because they are the most effective in preventing unintended pregnancies and have
lower failure rates.
This books highlights the methods and mechanisms by which epigenetics with a focus
on DNA methylation can be studied and its impacts on health.
In the first part, the first chapter focuses on the modeling and feedback dynamics of
DNA methylation, discussing mechanisms and controlling factors as well as DNA
sequences pattern analyses and histone modifications and their association with
disease initiation. Most methods for detecting methylated-CpG islands rely on
chemical conversion of DNA by treatment with bisulfite....
In a recent contribution, Gallmeyer and Holli eld (2008) propose a model with heterogeneous
beliefs and short sale constraints. They are able to show some e¤ects of heterogeneous beliefs
and of short sales constraints on equilibrium volatility at a xed point in time through extensive
simulations. However, their constraints are imposed exogenously, while the rich dynamics obtained
in this paper come from the endogenous solvency constraints and binding regimes which arise
naturally from limited commitment....
The National Institute on Aging’s “Assets and Health Dynamics Among the Oldest-Old
(AHEAD) Survey” from 1993 is used to provide demographic and housing preference
information (e.g., assisted living, shared housing, conventional housing) on seniors over
70 years of age.
The title Perspectives on Complementary and Alternative Medicine was chosen for this
book to reflect the need for a critical overview of the subject areas that relate to the
development of complementary and alternative medicine (CAM) as part of a dynamic
process of change in contemporary society. The recent changes and developments in and
the exponential growth of CAM are explored from a wide range of perspectives and
covering several academic disciplines.
Biodiversity forms patterns not just across space, but also across time. New species
emerge, old ones become extinct; rates of diversification speed up and slow down.
These long-term patterns in evolution get their start in the generation-to-
generation processes of natural selection, genetic drift, and reproductive isolation.
When a lineage of organisms evolves over a few million years, these processes
can potentially produce a wide range of patterns (see ). Natural selec-
tion may produce a significant change in a trait such as body size, for example.
The poorly known mechanism of inhibition of cholinesterases by inorganic
mercury (HgCl2) has been studied with a view to using these enzymes as
biomarkers or as biological components of biosensors to survey polluted
areas. The inhibition of a variety of cholinesterases by HgCl2
was investi-gated by kinetic studies, X-ray crystallography, and dynamic light scatter-ing.