The committee is grateful for the contribution of participants at its three public meetings. The
presentations and discussions at these meeting were valuable in informing the committee about relevant
research findings, issues of interest in the research community, the perspectives of advocacy
organizations, and the concerns of individuals with breast cancer and their families. The agendas for these
meetings appear in Appendix A.
Genes contain the recipes for the
various proteins a cell needs to stay
healthy and function normally. Some
genes and the proteins they make can
influence how a breast cancer behaves
and how it might respond to a specific
treatment. Cancer cells from a tissue
sample can be tested to see which
genes are normal and abnormal. The
proteins they make can also be tested.
If the genetic recipe contains a mistake
the report will say “genetic mutation”
or “genetic abnormality.
Human glutamate carboxypeptidase II (GCPII) is a
co-catalytic metallopeptidase and its putative catalytic
domain is homologous to the aminopeptidases fromVibrio
proteolyticus and Streptomyces griseus.In humans, the
enzyme is expressed predominantly in the nervous system
and theprostate.Theprostate form, termedprostate-specific
membraneantigen, is overexpressed inprostate cancer and is
used as a diagnostic marker of the disease.II
Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7), in particular, has been highlighted as an important marker in many types of
cancer by either inhibiting or promoting tumour growth.
By 2020, a better molecular definition of “health” and “ill-health” will have been achieved and early
markers that identify the transition between the two states will have been identified. This will be
delivered by studying cellular and molecular mechanisms of both states and by studying the interplay
between environmental factors to which the population is exposed and their genetic make-up.