Cancer genetic markers

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  • The committee is grateful for the contribution of participants at its three public meetings. The presentations and discussions at these meeting were valuable in informing the committee about relevant research findings, issues of interest in the research community, the perspectives of advocacy organizations, and the concerns of individuals with breast cancer and their families. The agendas for these meetings appear in Appendix A.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

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  • Genes contain the recipes for the various proteins a cell needs to stay healthy and function normally. Some genes and the proteins they make can influence how a breast cancer behaves and how it might respond to a specific treatment. Cancer cells from a tissue sample can be tested to see which genes are normal and abnormal. The proteins they make can also be tested. If the genetic recipe contains a mistake the report will say “genetic mutation” or “genetic abnormality.

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  • Human glutamate carboxypeptidase II (GCPII) is a co-catalytic metallopeptidase and its putative catalytic domain is homologous to the aminopeptidases fromVibrio proteolyticus and Streptomyces griseus.In humans, the enzyme is expressed predominantly in the nervous system and theprostate.Theprostate form, termedprostate-specific membraneantigen, is overexpressed inprostate cancer and is used as a diagnostic marker of the disease.II

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  • Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7), in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth.

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  • By 2020, a better molecular definition of “health” and “ill-health” will have been achieved and early markers that identify the transition between the two states will have been identified. This will be delivered by studying cellular and molecular mechanisms of both states and by studying the interplay between environmental factors to which the population is exposed and their genetic make-up.

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