Being diagnosed with cancer is devastating. But when the cancer cells have to spread
to form secondary colonies, the prognosis for the patient is worse. If meaningful
improvements in survival are to occur, then control of metastasis will be a
foundation. Relatively little is known about the control of the metastatic process at
the molecular level. This volume begins to explore our current knowledge regarding
the underlying molecular and biochemical mechanisms controlling the metastatic
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Lung cancer metastasis to the scapula and spine: a case report...
Standard treatment of anal cancer is a protocol of
combined chemotherapy and radiotherapy.
Typically, a diagnosis of LSIL results only in
more frequent monitoring in case it progresses to
HSIL. When HSIL is diagnosed, treatment may
be called for to reduce the likelihood of progres-
sion to cancer. This may include surgical
removal of the lesions.
Data on the efficacy of treatment are scarce.
However, treatment of cervical lesions has been
shown to be effective in substantially reducing
the risk of progression to cancer....
Harrison's Internal Medicine Chapter 80. Cancer Cell Biology and Angiogenesis
Cancer Cell Biology and Angiogenesis: Introduction Two characteristic features define a cancer: unregulated cell growth and tissue invasion/metastasis. Unregulated cell growth without invasion is a feature of benign neoplasms, or new growths. Cancer is a synonym for malignant neoplasm. Cancers of epithelial tissues are called carcinomas; cancers of nonepithelial (mesenchymal) tissues are called sarcomas. Cancers arising from hematopoietic or lymphoid cells are called leukemias or lymphomas.
There are four types of cutaneous melanoma (Table 83-2). In three of these—superficial spreading melanoma, lentigo maligna melanoma, and acral lentiginous melanoma—the lesion has a period of superficial (so-called radial) growth during which it increases in size but does not penetrate deeply. It is during this period that the melanoma is most capable of being cured by surgical excision. The fourth type—nodular melanoma—does not have a recognizable radial growth phase and usually presents as a deeply invasive lesion, capable of early metastasis.
Staging Correct staging of breast cancer patients is of extraordinary importance. Not only does it permit an accurate prognosis, but in many cases therapeutic decisionmaking is based largely on the TNM (primary tumor, regional nodes, metastasis) classification (Table 86-1). Comparison with historic series should be undertaken with caution, as the staging has changed several times in the past 20 years. The current staging is complex and results in significant changes in outcome by stage as compared with prior staging systems.
It is becoming increasingly clear that signals generated in tumor microenvi-ronments are crucial to tumor cell behavior, such as survival, progression
and metastasis. The establishment of these malignant behaviors requires
that tumor cells acquire novel adhesion and migration properties to detach
from their original sites and to localize to distant organs.
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated
in pathological processes, such as carcinogenesis. In this regard, their activity
plays a pivotal role in tumor growth and the multistep processes of invasion
and metastasis, including proteolytic degradation of ECM
Solid tumours are complex structures in which the interdependent relation-ship between tumour and endothelial cells modulates tumour development
and metastasis dissemination. The tumour microenvironment plays an
important role in this cell interplay, and changes in its features have a
major impact on tumour growth as well as on anticancer therapy respon-siveness.
Cancer can be defined as a disease in which a group of abnormal cells grow uncontrollably by disregarding the normal rules of cell division. Normal cells are constantly subject to signals that dictate whether the cell should divide, differentiate into another cell or die. Cancer cells develop a degree of autonomy from these signals, resulting in uncontrolled growth and proliferation. If this proliferation is allowed to continue and spread, it can be fatal. In fact, almost 90% of cancer-related deaths are due to tumour spreading – a process called metastasis....
Two studies in Africa evaluated the feasibility of using two visual inspection methods for cervical cancer
screening and assessed their performance in the field; the methods were VIA and visual inspection with Lugol’s
iodine (VILI). Women in the studies were between 25 and 59 years of age, with at least 73 percent younger than
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Liver metastasis originating from colorectal cancer with macroscopic portal vein tumor thrombosis: a case report and review of the literature
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Non-small cell lung cancer presenting with choroidal metastasis as first sign and showing good response to chemotherapy alone: a case report...
Two characteristic features define a cancer: unregulated cell growth and tissue invasion/metastasis. Unregulated cell growth without invasion is a feature of benign neoplasms, or new growths. Cancer is a synonym for malignant neoplasm. Cancers of epithelial tissues are called carcinomas; cancers of nonepithelial (mesenchymal) tissues are called sarcomas. Cancers arising from hematopoietic or lymphoid cells are called leukemias or lymphomas. Cancer is a genetic disease.
We especially paid attention not to
distend the bladder too much to prevent a high irrigation pressure and a resultant TUR
syndrome. Special attention was paid to avoid the injury to Santorini’s plexus and the
rectum. The procedure was started from the 12 o’clock position, dividing the prostate into
6 parts, and resected specimens were collected separately to examine the distribution of
cancer. The seminal vesicle was partially resected at its attached part to the prostate
between the 4 and 8 o’clock positions to determine the invasion of cancer.