Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation...
The endocannabinoid system is a conserved system involved in the modula-tion of several physiologic processes, from the activity of the central ner-vous system to reproduction. Type 1 cannabinoid receptor (CNR1) cDNA
was cloned from the brain and testis of the anuran amphibian, the frog
We have investigated the existence of a precoupled form of the distal C-ter-minal truncated cannabinoid receptor 1 (CB1-417) and heterotrimeric
G proteins in a heterologous insect cell expression system. CB1-417 showed
higher production levels than the full-length receptor. The production lev-els obtained in our expression system were double the values reported in
Loss of cannabinoid receptors (CB1) occurs prior to neuro-degeneration in Huntington’s disease (HD). The levels and
distribution of CB1 RNA were equivalent in 3-week-old
mice regardless of genotype demonstrating that the specific
factors and appropriate chromatin structure that lead to the
transcription ofCB1were present in the striatum of young
R6/2 and R6/1 transgenic HD mice.
The last decade or so has seen remarkable advances in our knowledge of cough. This
applies especially to its basic mechanisms: the types of airway sensors, the pharmacological
receptors on their membranes, the brainstem organization of the ‘cough
centre’, and the involvement of the cerebral cortex in the sensations and the voluntary
control of cough. With the exception of the last of these, nearly all the studies
have been on experimental animals rather than humans, for obvious reasons.
Less than 20 years ago the field of cannabis and the cannabinoids was still considered
a minor, somewhat quaint, area of research. A few groups were active in
the field, but it was already being viewed as stagnating. The chemistry of cannabis
was well known, Δ9-tetrahydrocannabinol (Δ9-THC), identified in 1964, being the
only major psychoactive constituent and cannabidiol, which is not psychoactive,
possibly contributing to some of the effects. These cannabinoids and several synthetic
analogs had been thoroughly investigated for their pharmacological effects.
Public opinion on the medical value of marijuana has been
sharply divided. Some dismiss medical marijuana as a
hoax that exploits our natural compassion for the sick; others
claim it is a uniquely soothing medicine that has been
withheld from patients through regulations based on false
claims. Proponents of both views cite “scientific evidence”
to support their views and have expressed those views at
the ballot box in recent state elections.
The life cycle of the retrovirus consist of several steps. It begins with the binding of the viral
envelope to cellular receptors, which enables fusion of the viral envelope with the cellular
membrane. Consequently, the viral particle is uncoated, liberating the viral core into the cell
cytoplasm. The viral DNA is reverse transcribed to DNA. Then, the viral DNA is
transported to the nucleus where it is integrated into the host cell’s genome. From there,
viral DNA is transcribed to RNA, some of which is translated to proteins.
Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.
An emerging body of evidence supports a key role for the endocannabinoid
system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have
examined the putative protective or toxic effects of drugs interacting with
cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.
Anandamide is an endogenous ligand for cannabinoid
receptor and its protein-mediated transport across cellular
membranes has been demonstrated in cells derived from
brain as well as in cells of the immune system. This lipid
is inactivated via intracellular degradation by a fatty acid
amidohydrolase (FAAH). In the present study, we report
that rabbit platelets, in contrast to human platelets, do not
possess a carrier-mediated mechanism for the transport of
H]anandamide into the cell, i.e. cellular uptake was not
temperature dependent and its accumulation was not satu-rable. ...