Public opinion on the medical value of marijuana has been
sharply divided. Some dismiss medical marijuana as a
hoax that exploits our natural compassion for the sick; others
claim it is a uniquely soothing medicine that has been
withheld from patients through regulations based on false
claims. Proponents of both views cite “scientific evidence”
to support their views and have expressed those views at
the ballot box in recent state elections.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis...
The endocannabinoid system is a conserved system involved in the modula-tion of several physiologic processes, from the activity of the central ner-vous system to reproduction. Type 1 cannabinoid receptor (CNR1) cDNA
was cloned from the brain and testis of the anuran amphibian, the frog
Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.
To be considered as a “peer reviewed, funded project,” the responsible funding agency or organization
should meet the general NIH standards of peer review and funding. These include meeting three
criteria: (1) a peer review system which uses primarily external reviewers and is free of
conflict-of-interest; (2) a ranking or rating system in the review process based on the scientific merit of
the proposed research; and (3) a funding system based primarily on the peer review ranking or rating of
the research applications....
An emerging body of evidence supports a key role for the endocannabinoid
system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have
examined the putative protective or toxic effects of drugs interacting with
cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.
We have investigated the existence of a precoupled form of the distal C-ter-minal truncated cannabinoid receptor 1 (CB1-417) and heterotrimeric
G proteins in a heterologous insect cell expression system. CB1-417 showed
higher production levels than the full-length receptor. The production lev-els obtained in our expression system were double the values reported in
Thus, ultrafine dusts of the same dimensions as nanoparticles mainly penetrate the body via
inhalation and are deposited in the lungs. A portion of these dusts can be distributed directly to
the brain via the olfactory nerves. The lungs do not necessarily succeed in totally eliminating
these undesirable particles, which then cause pulmonary inflammation. This can lead to the
development of lung diseases specific to the nature of the dusts that caused them.
together we must make a decisive move, now, to improve the health of women and children around the
world. we know what works. we have achieved excellent progress in a short time in some countries.
the answers lie in building our collective resolve to ensure universal access to essential health services
and proven, life-saving interventions as we work to strengthen health systems. these range from family
planning and making childbirth safe, to increasing access to vaccines and treatment for hIV and aIds,
malaria, tuberculosis, pneumonia and other neglected diseases.
Anandamide is an endogenous ligand for cannabinoid
receptor and its protein-mediated transport across cellular
membranes has been demonstrated in cells derived from
brain as well as in cells of the immune system. This lipid
is inactivated via intracellular degradation by a fatty acid
amidohydrolase (FAAH). In the present study, we report
that rabbit platelets, in contrast to human platelets, do not
possess a carrier-mediated mechanism for the transport of
H]anandamide into the cell, i.e. cellular uptake was not
temperature dependent and its accumulation was not satu-rable. ...