Less than 20 years ago the field of cannabis and the cannabinoids was still considered
a minor, somewhat quaint, area of research. A few groups were active in
the field, but it was already being viewed as stagnating. The chemistry of cannabis
was well known, Δ9-tetrahydrocannabinol (Δ9-THC), identified in 1964, being the
only major psychoactive constituent and cannabidiol, which is not psychoactive,
possibly contributing to some of the effects. These cannabinoids and several synthetic
analogs had been thoroughly investigated for their pharmacological effects.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation...
The endocannabinoid system is a conserved system involved in the modula-tion of several physiologic processes, from the activity of the central ner-vous system to reproduction. Type 1 cannabinoid receptor (CNR1) cDNA
was cloned from the brain and testis of the anuran amphibian, the frog
Public opinion on the medical value of marijuana has been
sharply divided. Some dismiss medical marijuana as a
hoax that exploits our natural compassion for the sick; others
claim it is a uniquely soothing medicine that has been
withheld from patients through regulations based on false
claims. Proponents of both views cite “scientific evidence”
to support their views and have expressed those views at
the ballot box in recent state elections.
We have investigated the existence of a precoupled form of the distal C-ter-minal truncated cannabinoid receptor 1 (CB1-417) and heterotrimeric
G proteins in a heterologous insect cell expression system. CB1-417 showed
higher production levels than the full-length receptor. The production lev-els obtained in our expression system were double the values reported in
Loss of cannabinoid receptors (CB1) occurs prior to neuro-degeneration in Huntington’s disease (HD). The levels and
distribution of CB1 RNA were equivalent in 3-week-old
mice regardless of genotype demonstrating that the specific
factors and appropriate chromatin structure that lead to the
transcription ofCB1were present in the striatum of young
R6/2 and R6/1 transgenic HD mice.
The plant Cannabis sativa L. has a long history for human being since about BC 2000 for its use as fiber material, food and folk medicine; cannabis (hemp, marijuana) means the whole plant itself and its dried products except for its stem and seeds. The word “hashish” is mainly used for the resin of the cannabis plant.
Thus, in living cells, the rates of anterograde and retrograde transport between the two
organelles appear to have a substantial effect on the morphology of the Golgi. The effect of
the balance between anterograde and retrograde transport on the morphology of the ER
remains to be explored. Recently, increasing evidence has suggested that alteration in Golgi
morphology during mitosis is not a passive process but rather an active one, which is highly
coordinated with entry into mitosis and its progression.
The life cycle of the retrovirus consist of several steps. It begins with the binding of the viral
envelope to cellular receptors, which enables fusion of the viral envelope with the cellular
membrane. Consequently, the viral particle is uncoated, liberating the viral core into the cell
cytoplasm. The viral DNA is reverse transcribed to DNA. Then, the viral DNA is
transported to the nucleus where it is integrated into the host cell’s genome. From there,
viral DNA is transcribed to RNA, some of which is translated to proteins.
Acute haematogenous osteomyelitis refers to infection of bone resulting from bacteria in the
bloodstream. This is seen most often in children, with initial infection thought to occur in the
richly vascularised metaphyseal region (Gutierrez, 2005). Children are thought to experience
frequent episodes of bacteraemia, often with no apparent symptoms, leading to seeding and
development of osteomyelitis (Conrad, 2010). The pathogenesis of this process has been
Các chất hoạt tính trong cần sa có thể làm giảm triệu chứng viêm sưng trong bệnh Bộ não. Alzheimer và do đó giúp ngăn ngừa sự suy thoái của hệ thần kinh. Hợp chất tổng hợp đó được gọi là cannabinoid. Các nhà khoa học đến từ Đại học Complutense ở Madrid và Viện nghiên cứu Cajal (Tây Ban Nha) đã ghi nhận được những tác dụng đầu tiên của cần sa đối với căn bệnh Alzheimer.
The tax-exempt money market is more complex than the taxable money
market. That’s largely because of a supply-and-demand imbalance for very
short-term municipal securities. There’s a high level of demand for these
issues—much of it coming from individuals who want to minimize their tax
bill by placing their cash in a tax-exempt money market mutual fund. But
supply is limited.
In response to Texas’s affiliate rule, the federal Centers for Medicare and Medicaid
Services (CMS) announced that it would no longer provide federal matching funds for the
program because the rule denies beneficiaries the freedom to choose providers, as assured under
federal policy and stated that the waiver and federal funding would terminate after six months.
Two lawsuits are now in progress as a result of these decisions.
Le Centre de Développement des Ressources de la Terre (l'un des organismes
scientifiques de l'Administration Britannique de Développement Outremer) apporte son
aide aux pays en voie de développement en matière de cartographie, recherche et
evaluation des ressources de la terre et fourni t des recommandations quant ä
l'exploitation de ces ressources pour le développement de l'agriculture, l'élevage et la
The last decade or so has seen remarkable advances in our knowledge of cough. This
applies especially to its basic mechanisms: the types of airway sensors, the pharmacological
receptors on their membranes, the brainstem organization of the ‘cough
centre’, and the involvement of the cerebral cortex in the sensations and the voluntary
control of cough. With the exception of the last of these, nearly all the studies
have been on experimental animals rather than humans, for obvious reasons.
Since car-sharing is beneficial to society in a variety of ways, it is felt that public authorities
should provide those engaged in cars-sharing with certain benefits. At the same time, a
number of quality requirements are clearly needed in order to ensure that the benefits have the
desired effect wi thout this being misused, and that car-sharing contribute in a genuine way to
the goals of society.