Adrenocortical carcinoma (ACC) is a disease that most physicians, including many
endocrinologists, will rarely, if ever, diagnose or let alone treat during the course
of their medical practice. Medical textbooks of endocrinology and oncology rarely
dedicate an entire chapter to this disease entity. The pursuit of research and clinical
excellence in uncommon diseases is extremely challenging because of a lack of
research prioritization, nonexistent treatment guidelines and overall paucity of coordination
between researchers and physicians.
Chapter 088. Hepatocellular Carcinoma (Part 6)
Hepatocellular Carcinoma: Treatment Most HCC patients have two liver diseases, cirrhosis and HCC, each of which is an independent cause of death. The presence of cirrhosis usually places constraints on resection surgery, ablative therapies, and chemotherapy. Thus patient assessment and treatment planning have to take the severity of the nonmalignant liver disease into account. The clinical management choices for HCC can be complex (Fig. 88-1). The natural history of HCC is highly variable.
Renal Cell Carcinoma: Treatment
Localized Tumors The standard management for stage I or II tumors and selected cases of stage III disease is radical nephrectomy. This procedure involves en bloc removal of Gerota's fascia and its contents, including the kidney, the ipsilateral adrenal gland, and adjacent hilar lymph nodes. The role of a regional lymphadenectomy is controversial. Extension into the renal vein or inferior vena cava (stage III disease) does not preclude resection even if cardiopulmonary bypass is required.
Harrison's Internal Medicine Chapter 95. Carcinoma of Unknown Primary
Carcinoma of Unknown Primary: Introduction Carcinoma of unknown primary (CUP) is a biopsy-proven (mainly epithelial) malignancy for which the anatomic site of origin remains unidentified after an intensive search. CUP is one of the 10 most frequently diagnosed cancers worldwide, accounting for approximately 3–5% of all cancer cases.
Gastric cancer is the second most common cause of cancer-related death in the world. There are no screening tests available for its diagnosis, therefore patients usually presents in late stages, associated with poor prognosis. Currently, many efforts are made toward new advances in the treatment strategies. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis.
The treatment of a tumor that has invaded muscle can be separated into control of the primary tumor and, depending on the pathologic findings at surgery, systemic chemotherapy. Radical cystectomy is the standard, although in selected cases a bladder-sparing approach is used; this approach includes complete endoscopic resection; partial cystectomy; or a combination of resection, systemic chemotherapy, and external beam radiation therapy. In some countries, external beam radiation therapy is considered standard.
The primary goal of treatment for metastatic disease is to achieve complete remission with chemotherapy alone or with a combined-modality approach of chemotherapy followed by surgical resection of residual disease, as is done routinely for the treatment of germ cell tumors. One can define a goal in terms of cure or palliation on the basis of the probability of achieving a complete response to chemotherapy using prognostic factors, such as Karnofsky Performance Status (KPS) (...
Treatment algorithm for tomography; chemotherapy. PET, positron
squamous cell CUP. tomography; RT,
CT, computed radiation; C,
Treatment of Favorable Subsets of CUP
Women with Isolated Axillary Adenopathy
Women with isolated axillary adenopathy with adenocarcinoma or carcinoma should be treated for stage II or III breast cancer. These patients should undergo a breast MRI if mammogram and ultrasound are negative. Radiation therapy to the ipsilateral breast is indicated if the breast MRI is positive.
Synthetic progestogens (administered orally or parenterally) are recommended as first-line ther-
apy for the management of troublesome hot flushes. If oral therapy is used, it should be given
for 2 weeks, and re-started, if effective, on recurrence of symptoms.
Men starting long-term bicalutamide monotherapy ( 6 months) should receive prophylactic
radiotherapy to both breast buds within the first month of treatment. A single fraction of 8 Gy
using orthovoltage or electron beam radiotherapy is recommended.
(BQ) Part 1 book "Carly cancer of the gastrointestinal tract endoscopy, pathology, and treatment" presents the following contents: Case presentations - Clinical data, endoscopy, and pathology; vienna consensus criteria for pathological diagnosis; early neoplasia in barrett’s esophagus.
(BQ) Part 2 book "Radiation treatment and radiation reactions in dermatology" presents the following contents: Superficial radiation therapy in an office setting, tumor staging in dermatology, treatment of precancerous lesions, electron therapy of skin carcinoma, cutaneous melanoma, side effects of radiation treatment,...
I have been involved in the treatment of chronic renal insuffi ciency for 40 years,
beginning with peritoneal dialysis immediately after graduation from medical school
in 1965, then with hemodialysis in 1967 after I fi rst experienced it in Kanazawa, and
with renal transplantation since 1972, when I was studying in the United States.
During this period, the number of dialysis patients has continued to increase rapidly
to the present fi gure of 257 765 (at the end of 2005), and with surprising increases in
the survival rate.
Combined methods have led to further refinements
with, for example, high visuospatial resolution afforded by MRI combined with
metabolic information from the lesion site (measured with 18F-fluorodeoxyglucose
positron emission tomography; FDG-PET) to indicate location and malignancy of
gliomas, which in turn informs radiosurgical targeting. Kapsalaki et al. (Chapter 7)
consider MRS spectroscopic profiles for differentiation among ring enhancing lesions
including high grade gliomas, abscesses and post-radiation necrosis.
The prognosis for individuals with liver cancer is frequently poor. Cancers include those which have metastasized to the liver from elsewhere, reflecting advanced stage disease where cure is rarely possible. Similarly, primary liver cancer frequently complicates chronic liver disease, which further limits therapeutic options. Despite these dismal facts, there are signs that change is imminent. Not only have imaging modalities and surgical techniques improved, but preventive strategies and medical therapies show promise.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài:
Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
Tissue Engineering is the first medical therapy where engineered tissues could
potentially become fully integrated within the patient, thus offering a permanent cure
for many diseases not curable today.
Carcinoma of the lung is the most common cause of cancer-related death in men and women.
Prognosis correlates strongly with stage of disease at presentation and to some degree with
the histological subtype of the tumor. Histological classifications of lung cancer were somewhat
arbitrary and a matter of convenience. However, multiple lines of differentiation are
often found within a single tumor, if it is sufficiently sampled.
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P32 provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options.
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P35 provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options.