Mutations in neuroserpin anda1-antitrypsin cause these proteins to form
ordered polymers that are retained within the endoplasmic reticulum of
neurones and hepatocytes, respectively. The resulting inclusions underlie
the dementia familial encephalopathy with neuroserpin inclusion bodies
(FENIB) and Z a1-antitrypsin-associated cirrhosis.
It was November 1901, and Karl Deter of Germany did not
know what to do about his wife, Auguste. Over the previous
several months, her behavior had changed drastically. Only fiftyone
years old, Auguste had lost the ability to remember things
from one minute to the next. She had lost the ability to express
herself with words. She was often confused about what day it
was, where she was, and even who she was. She had frequent
outbursts of anger and paranoid thinking. She would hide
things, thinking her family was trying to steal from her.
Presents cutting-edge information on a variety of dementia-causing illnesses.
Provides relevant material for professionals working with AIDS patients, substance abusers, stroke or other vascular patients, and other individuals suffering from degenerative illness.
Edited by leading experts in geriatric health and dementia.
The field of movement disorders is relatively broad, encompassing disorders of increased
movement, such as tremors, dystonia, and tics, to disorders characterized by a
paucity of movement, such as Parkinson’s disease. Our understanding of the pathogenic
mechanisms and our treatment options are expanding at a rapid pace. This expansion
ranges from the medical and surgical advances in treating Parkinson’s disease to the flood
of genetic abnormalities that have now been found to cause various movement disorders.
Coma: a state of unconsciousness from which the patient cannot be aroused, even by powerful stimuli. Traumatic brain injuries are the most frequent cause; other causes include severe uncontrolled diabetes mellitus, liver disease, kidney disease, and neurologic conditions
Dementia: a general loss of mental abilities, including impairment of memory and often impairments in speech, coordination, ability to understand sensory stimuli, and other mental faculties.
The dementia familial encephalopathy with neuroserpin
inclusion bodies (FENIB) is caused by point mutations in
the neuroserpin gene.We have shown a correlation between
the predicted effect of the mutation and the number of
intracerebral inclusions, and an inverse relationshipwith the
age of onset of disease. Our previous work has shown that
the intraneuronal inclusions in FENIB result from the
sequential interactionbetween the reactive centre loopofone
neuroserpin molecule withb-sheet A of the next. ...
Among all the clinical indications for which radiologists, nuclear medicine physicians,
neurologists, neurosurgeons, psychiatrists (and others examining disorders of
the brain) order and read brain PET scans, demand is greatest for those pertaining
to dementia and related disorders. This demand is driven by the sheer prevalence of
those conditions, coupled with the fact that the differential diagnosis for causes of
cognitive impairment is wide and often difficult to distinguish clinically.
Agitation (dễ cáu gắt) is an unpleasant state of extreme arousal, increased tension, and irritability anxiety (lo lắng)
Fear or apprehension or dread of impending danger and accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.
Evidence of left hemispatial neglect and simultanagnosia. A. A 47-yearold man with a large frontoparietal lesion in the right hemisphere was asked to circle all the As. Only targets on the right are circled. This is a manifestation of left hemispatial neglect. B. A 70-year-old woman with a 2-year history of degenerative dementia was able to circle most of the small targets but ignored the larger ones. This is a manifestation of simultanagnosia.Cerebrovascular lesions and neoplasms in the right hemisphere are the most common causes of hemispatial neglect.
Despite the theoretical advantages of identifying individuals with
cognitive impairment, there is no evidence to indicate whether this
leads to a net benefit or risk to the individual. Although pharmaceutica
agents are able to produce measurable changes in cognitive
performance in people with Alzheimer’s disease, none has been shown
to result consistently in clinically significant improvement. The high
cost of investigation to exclude reversible causes of dementia, and the
negative effects of labelling are examples of potential harm.
Insomnia Associated with Neurologic Disorders
A variety of neurologic diseases result in sleep disruption through both indirect, nonspecific mechanisms (e.g., pain in cervical spondylosis or low back pain) or by impairment of central neural structures involved in the generation and control of sleep itself. For example, dementia from any cause has long been associated with disturbances in the timing of the sleep-wake cycle, often characterized by nocturnal wandering and an exacerbation of symptomatology at night (so-called sundowning).
Nevertheless, this report provides an overview of issues related to women’s health across
the EU Member States also including EEA countries. It highlights gaps and special topics
where research and more information are needed.