Cell cycle distribution
-
The aim of this study was to investigate the response of two canine mammary tumour cell lines, CIPp from a primary tumour and CIPm, from its lymph node metastasis, to exposure to EC50(20h) DOX at 12, 24 and 48 h of treatment. We assessed the uptake and subcellular distribution of DOX, the expression and function of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), two important MDR mediators.
15p vidarwin 23-02-2022 10 1 Download
-
Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) has been implicated in multiple tumor type progression.
11p vielonmusk 21-01-2022 10 1 Download
-
Peripheral blood and haematopoiesis in bone marrow and liver tissue were investigated in Bufo bufo during the sexual cycle. A combined touch and imprinting tissue method were applied for the haematopoietic cell isolation. The liver is the primary site of erythropoiesis and partial lymphopoiesis. There was a positive correlation between body mass and liver mass, but it was not significant (P > 0.05). The primary role of yellow bone marrow is the maturation of haematopoietic cells, while red bone marrow is responsible for the production of blood cells.
9p dolomite36 30-12-2021 7 0 Download
-
The potential DNA demethylating properties of the analyzed compounds were tested by MethylationSensitive High Resolution Melting (MS-HRM). Cell cycle distribution was tested using Fluorescence-Activated Cell Sorting (FACS), whereas apoptosis was analyzed using FITC Annexin V/propidium iodide double staining assay and Western blot.
15p lazzaro 30-12-2021 7 0 Download
-
Molecular targeted therapy for non-small cell lung carcinoma (NSCLC) is restricted due to resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This study evaluated the efects of dual targeting of MEK and PI3K in human EGFR-TKI resistant NSCLC cell lines.
12p vimackenziebezos 29-11-2021 4 1 Download
-
Lecture Biology (6e) - Chapter 12: The cell cycle. This chapter presents the following content: Cell division functions in reproduction, growth, and repair; cell division distributes identical sets of chromosomes to daughter cells.
66p tradaviahe19 29-03-2021 14 1 Download
-
Prognosis of adult patients suffering from acute lymphoblastic leukemia (ALL) is still unsatisfactory. Targeted therapy via inhibition of deregulated signaling pathways appears to be a promising therapeutic option for the treatment of ALL.
9p virose2711 25-09-2020 10 0 Download
-
Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and migration in human HCC MHCC-97 L cells.
9p vinaypyidaw2711 26-08-2020 10 1 Download
-
The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma.
19p vibaku2711 22-07-2020 17 1 Download
-
Cell adhesion-mediated drug resistance (CAM-DR) is a major clinical problem that prevents successful treatment of multiple myeloma (MM). In particular, the expression levels of integrin β1 and its sub-cellular distribution (internalization and trafficking) are strongly associated with CAM-DR development.
16p vikuala271 13-06-2020 21 0 Download
-
Poly(b-L-malate) (PMLA) has been reported as an uncon-ventional, physiologically important biopolymer in plasmo-dia of myxomycetes, and has been proposed to function in the storage and transport of nuclear proteins by mimicking the phospho(deoxy)ribose backbone of nucleic acids. It is distributed in the cytoplasm and especially in the nuclei of these giant, multinucleate cells. We report here for the first time an increase in growth rate and a shortening of the cell cycle after the injection of purified PMLA. ...
7p awards 05-04-2013 42 2 Download
-
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthes-ized primarily in the pineal gland and is regulated by the environmental light⁄dark cycle via the suprachiasmatic nucleus.
26p inspiron33 25-03-2013 35 3 Download
-
The potential value of artificial neural networks (ANNs) as a predictor of malignancy has now been widely recognised. The concept of ANNs dates back to the early part of the 20th century; however, their latest resurrection started in earnest in the 1980s when they were applied to many problems in the areas of pattern recognition, control, and optimisation.
212p echbuon 02-11-2012 97 7 Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Computational Methods for Estimation of Cell Cycle Phase Distributions of Yeast Cells
9p dauphong19 07-03-2012 54 3 Download