After studying this chapter, you should be able to accomplish the following outcomes: List the four stages of interphase, and describe the major events that occur during each stage in preparation for cell division; describe the difference between mitosis and cytokinesis; list the checkpoints that regulate the progression of cells through the cell cycle;...
Poly(b-L-malate) (PMLA) has been reported as an uncon-ventional, physiologically important biopolymer in plasmo-dia of myxomycetes, and has been proposed to function in
the storage and transport of nuclear proteins by mimicking
the phospho(deoxy)ribose backbone of nucleic acids. It is
distributed in the cytoplasm and especially in the nuclei of
these giant, multinucleate cells. We report here for the first
time an increase in growth rate and a shortening of the cell
cycle after the injection of purified PMLA. ...
The naturally synchronous plasmodia of myxomycetes synthesize poly(b-L-malic acid), which carries out cell-speciﬁc functions. In Physarum polycephalum, poly(b-L-malate) [the salt form of poly(b-L-malic acid)] is highly concentrated in the nuclei, repressing DNA synthetic activity of DNA polymerases by the formation of reversible complexes. To test whether this inhibitory activity is cell-cycle-dependent, puriﬁed DNA polymerase a of P.
Sterol regulatory element-binding proteins 1 and 2 (SREBP-1 and SREBP-2) are important regulators of genes involved in cholesterol and fatty acid
metabolism, but have also been implicated in the regulation of the cell
cycle and have been associated with the pathogenesis of type 2 diabetes,
atherosclerosis and obesity, among others.
This chapter provides knowledge of cell cycle. The main contents of this chapter include all of the following: List the phases of the cell cycle and describe the key events of each phase, describe the process of DNA replication.
(BQ) Part 2 book "High-Yield cell and molecular biology - Cell and molecular biology" presents the following contents: Proto-Oncogenes, oncogenes and tumor-suppressor genes, the cell cycle, molecular biology of cancer, cell biology of the immune system, cell biology of the immune system, molecular biology techniques, identification of human disease genes, gene therapy.
Induction of p53 by the DNA damage and oncogene checkpoints.
In response to noxious stimuli, p53 and mdm2 are phosphorylated by the ataxia telangiectasia mutated (ATM) and related ATR serine/threonine kinases, as well as the immediated downstream checkpoint kinases, Chk1 and Chk2. This causes dissociation of p53 from mdm2, leading to increased p53 protein levels and transcription of genes leading to cell cycle arrest (p21Cip1/Waf1) or apoptosis (e.g., the proapoptotic Bcl-2 family members Noxa and Puma).
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins
Some limited understanding of self-renewal exists and, intriguingly, implicates gene products that are associated with the chromatin state, a high-order organization of chromosomal DNA that influences transcription. These include members of the polycomb family, a group of zinc finger–containing transcriptional regulators that interact with the chromatin structure, contributing to the accessibility of groups of genes for transcription.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment
Signaling Pathways Downstream of Rtks: Ras and PI3K Several oncogene and tumor-suppressor gene products are components of signal transduction pathways that emanate from RTK activation (Fig. 80-2). The most extensively studied are the Ras/mitogen-activated protein (MAP) kinase pathway and the phosphatidylinositol-3-kinase (PI3K) pathway, both of which regulate multiple processes in cancer cells, including cell cycle progression, resistance to apoptotic signals, angiogenesis, and cell motility.
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Using single cell cultivation system for on-chip monitoring of the interdivision timer in Chlamydomonas reinhardtii cell cycle
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:
Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway
An increasing amount of expressed sequence tag (EST) and genomic data,
predominantly for the cnidarians Acropora, Hydraand Nematostella,
reveals that cnidarians have a high genomic complexity, despite being one
of the morphologically simplest multicellular animals.
The cell cycle-dependent element (CDE) and the cell cycle genes homology
region (CHR) control the transcription of genes with maximum expression
phase and in mitosis. Promoters of these genes are repressed by pro-teins binding to CDE⁄CHR elements in G0 and G1 phases. Relief from
repression begins in S phase and continues into G2
phase and mitosis.
MCM4, a subunit of a putative replicative helicase, is phosphorylated dur-ing the cell cycle, at least in part by cyclin-dependent kinases (CDK), which
play a central role in the regulation of DNA replication. However, detailed
characterization of the phosphorylation of MCM4 remains to be per-formed.