Cell death induction by tumor necrosis factor has been an intensively stud-ied area for the last two decades. Although it may appear that the skeleton
should have been picked clean by now, new secrets about tumor necrosis
factor death signaling are still being uncovered.
Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell
death and autophagy. Although the kinase domain of DAPK has a range
of substrates that mediate its signalling, the additional protein interaction
domains of DAPK are relatively ill defined.
TheArabidopsis acd11mutant exhibits runaway, programmed cell death
due to the loss of a putative sphingosine transfer protein (ACD11) with
homology to mammalian GLTP. We demonstrate that transgenic expres-sion in Arabidopsis thalianaof human GLTP partially suppressed the
phenotype of theacd11null mutant, resulting in delayed programmed cell
death development and plant survival.
The Ras⁄Raf⁄extracellular signal-regulated kinase (ERK) signaling path-way plays a crucial role in almost all cell functions and therefore requires
exquisite control of its spatiotemporal activity. Depending on the cell type
and stimulus, ERK activity will mediate different antiproliferative events,
such as apoptosis, autophagy and senescence in vitro and in vivo.
The selection of functional T cells is mediated by interactions between the
T cell antigen receptor and self-peptide major histocompatibility complex
expressed on thymic epithelium. These interactions either lead to survival
and development or death.
Extracellular signal-related kinase (ERK) is a key player in cell signaling.
After 25 years of investigation, ERK has been associated with every major
aspect of cell physiology. Cell proliferation, cell transformation, protection
against apoptosis, among others, are influenced by ERK function.
Death-associated protein kinase (DAPK) regulates many distinct signalling
events, including apoptosis, autophagy and membrane blebbing. The role
of DAPK in the blebbing process is only beginning to be understood and,
in this review, we will first summarize what is known about the cytoskeletal
proteins and signalling cascades that participate in bleb growth and retrac-tion and then highlight how DAPK integrates with these processes.
Adenine nucleotide translocases (ANTs) are multitask proteins involved in
several aspects of cell metabolism, as well as in the regulation of cell
death⁄survival processes. We investigated the role played by ANT isoforms
1 and 2 in the growth of a human glioblastoma cell line (ADF cells). The
silencing of ANT2 isoform, by small interfering RNA, did not produce sig-nificant changes in ADF cell viability.
Cell death-inducing DFF45-like effector (CIDE) family proteins, including
cell death-inducing DFF45-like effector A (CIDEA), cell death-inducing
DFF45-like effector B (CIDEB) and cell death-inducing DFF45-like effec-tor C (CIDEC) [fat-specific protein of 27 kDa in rodent (FSP27) in
rodents], were originally identified by their sequence homology to the
N-terminal region of DNA fragmentation factor DFF40⁄45.
Exposure of cells to ionizing radiation induces activation of multiple signal-ing pathways that play a critical role in controlling cell death. However,
the basis for linkage between signaling pathways and the cell-death machin-ery in response to ionizing radiation remains unclear.
The goals of chemotherapy (and radiotherapy) are to eliminate tumor cell targets by
promoting cell death. In recent years, a major focus has been placed on programmed
cell death or apoptosis as the primary mechanism of cell killing. However, tumor
cells may respond to various forms of treatment in diverse ways, only some of which
culminate in cell death and loss of clonogenic survival. In addition to apoptosis, cell
death may occur through mitotic catastrophe, autophagy (a subtype of apoptosis), or
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity
Apoptosis in the developing nervous system results in naturally occurring
cell death (NOCD), a necessary and desirable process. NOCD effectively
eliminates neurons that have made faulty synapses or have not reached
In the rest of the organism, apoptosis is essential for
organogenesis, sculpts digits and extremities, and plays a role in determining
polarity of structures by contributing to directional growth of cell populations.
Failure of carefully orchestrated and effective apoptosis in the developing
fetus can have serious and long-lasting effects in the adult.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Delayed cell death associated with mitotic catastrophe in g-irradiated stem-like glioma cells...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells
During pupal metamorphosis, the anterior silk glands (ASGs) of the silk-wormBombyx moridegenerate through programmed cell death (PCD),
which is triggered by 20-hydroxyecdysone (20E). 20E triggers the PCD of
the ASGs of day 7 fifth instar (V7) larvae but not that of V5 larvae.
The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies....