Dehydroepiandrosterone (DHEA) has a protective role against epithelial-derived carcinomas; however, the mechanisms remain unknown. We deter-mined the effect of DHEA on cell proliferation, the cell cycle and cell
death in three cell lines derived from human uterine cervical cancers
infected or not with human papilloma virus (HPV).
We have investigated the possible involvement of two intracellular phos-pholipases A2, namely group VIA calcium-independent phospholipase A2
(iPLA2-VIA) and group IVA cytosolic phospholipase A2 (cPLA2a), in the
regulation of human promonocytic U937 cell proliferation.
Harrison's Internal Medicine Chapter 67. Applications of Stem Cell Biology in Clinical Medicine
Applications of Stem Cell Biology in Clinical Medicine: Introduction Organ damage and the resultant inflammatory responses initiate a series of repair processes, including stem cell proliferation, migration, and differentiation, often in combination with angiogenesis and remodeling of the extracellular matrix. Endogenous stem cells in tissues such as liver and skin have a remarkable ability to regenerate the organs, whereas heart and brain have a much more limited capability for self-repair.
Harrison's Internal Medicine Chapter 80. Cancer Cell Biology and Angiogenesis
Cancer Cell Biology and Angiogenesis: Introduction Two characteristic features define a cancer: unregulated cell growth and tissue invasion/metastasis. Unregulated cell growth without invasion is a feature of benign neoplasms, or new growths. Cancer is a synonym for malignant neoplasm. Cancers of epithelial tissues are called carcinomas; cancers of nonepithelial (mesenchymal) tissues are called sarcomas. Cancers arising from hematopoietic or lymphoid cells are called leukemias or lymphomas.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Protein kinase CK2a is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: An association between the acute phase response and patterns of antigen induced T cell proliferation in juvenile idiopathic arthritis...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro...
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes
Protein ubiquitination mediated by ubiquitin ligases plays a very important
role in a wide spectrum of biological processes including development and
disease pathogenesis. RING finger protein 13 (RNF13) is a recently identi-fied ubiquitin ligase which contains an N-terminal protease-associated
domain and a C-terminal RING finger domain separated by a transmem-brane region.
Chymases are chymotrypsin-like serine proteases that are found in large
amounts in mast cell granules. So far, the extended cleavage specificities of
eight such chymases have been determined, and four of these were shown
to have a strong preference for acidic amino acids at position P2¢. These
enzymes have basic amino acids in positions 143 and 192 (Arg and Lys,
TheArabidopsis acd11mutant exhibits runaway, programmed cell death
due to the loss of a putative sphingosine transfer protein (ACD11) with
homology to mammalian GLTP. We demonstrate that transgenic expres-sion in Arabidopsis thalianaof human GLTP partially suppressed the
phenotype of theacd11null mutant, resulting in delayed programmed cell
death development and plant survival.
Cell-free protein synthesis using cell extracts from
Escherichia coli, wheat germ and rabbit reticulocytes
has been used for over 40 years to produce small
amounts of radiolabeled proteins for identification of
gene products and other applications. In the E. coli
system programmed with plasmid DNA, the cell
extract contains or is supplemented with an RNA po-lymerase to transcribe the gene, and the mRNAs are
translated by a complex mixture that contains ribo-somes and a full complement of initiation,...
Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular
protein that contains the unusual amino acid hypusine [N
-(4-amino-2-hydroxybutyl)lysine]. Vertebrates carry two genes that encode two eIF5A
isoforms, eIF5A-1 and eIF5A-2, which, in humans, are 84% identical.
eIF5A-1 mRNA (1.3 kb) and protein (18 kDa) are constitutively expressed
in human cells. In contrast, expression of eIF5A-2 mRNA (0.7–5.6 kb) and
eIF5A-2 protein (20 kDa) varies widely.
We analyzed the role of gangliosides in the association of the ErbB2 recep-tor tyrosine-kinase (RTK) with lipid rafts in mammary epithelial HC11
cells. Scanning confocal microscopy experiments revealed a strict ErbB2–
GM3 colocalization in wild-type cells. In addition, analysis of membrane
fractions obtained using a linear sucrose gradient showed that ErbB2, epi-
Nitric oxide (NO
) has been proposed to be a physiological modulator of
cell proliferation, able to promote in most cases cell cycle arrest. In this
review I explore the molecular basis of this mechanism of action. The mod-ulatory action of NO
on the intracellular concentration of cGMP and the
machinery directly involved in the control of cell cycle progression, inclu-ding the expression and activity of diverse cyclins and cyclin-dependent
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1...