MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by
binding to target mRNAs in a sequence-specific manner. A large number
of genes appear to be the target of miRNAs, and an essential role for
miRNAs in the regulation of various conserved cell signaling cascades,
such as mitogen-activated protein kinase, Notch and Hedgehog
Cells respond to environmental cues through a complex and dynamic
network of signaling pathways that normally maintain a critical balance
between cellular proliferation, differentiation, senescence, and death. One
current research challenge is to identify those aberrations in signal transduction
that directly contribute to a loss of this division-limited equilibrium and
the progression to malignant transformation. The study of cell-signaling molecules
in this context is a central component of cancer research.
SỰ TRUYỀN TÍN HIỆU VÀ GIAO LƯU THÔNG TIN TẾ BÀO
(CELL SIGNALING AND COMMUNICATION)
Những năm cuối thế kỷ 20, một lĩnh vực sinh học phân tử tế bào gây ấn tượng mạnh là tín hiệu tế bào (cell signaling) đã phát triển nhanh và sẽ tiếp tục tiến triển trong thế kỉ 21. E.W. Sutherland là người mở đầu cho các nghiên cứu về các thông điệp (messenger) hóa học và tác động của chúng lên các con đường tín hiệu - dịch chuyển (signal-transduction).
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis...
Volume 3 of the book series Biomathematical and Biomechanical Modeling of
the Circulatory and Ventilatory Systems aims at presenting major sets of signaling
receptors mainly located at the plasma membrane, 1 in a modeling framework rather
than biological perspective. Collecting signaling effectors, their main interactions,
and major properties are the first tasks required for any modeling of cell signaling
The major objective is to comprehend the complexity of natural phenomena to
model these events. In other words, to yield the maximal amount of known information
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Abnormalities of T cell signaling in systemic lupus erythematosus...
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells
Extracellular signal-related kinase (ERK) is a key player in cell signaling.
After 25 years of investigation, ERK has been associated with every major
aspect of cell physiology. Cell proliferation, cell transformation, protection
against apoptosis, among others, are influenced by ERK function.
This study addresses the interactions between the adaptor protein Shb and components involved in T cell signalling, including SLP-76, Gads, Vav and ZAP70. We show that both SLP-76 and ZAP70 co-immunoprecipitate with Shb in Jurkat T cells and that Shb and Vav co-immunoprecipitate when cotransfected in COS cells. We also demonstrate, utilizing fusion protein constructs, that SLP-76, Gads and Vav associate independently of each other to diﬀerent domains or regions, of Shb.
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis...
Loss of tumor suppressors contributes to numerous cancer types. Many, but
not all, proteins encoded by tumor suppressor genes have antiproliferative activity
and halt cell-cycle progression. In this chapter, we present three methods
that have been utilized to monitor the antimitogenic action exerted by tumor
suppressors. Tumor suppressor function can be demonstrated by colony formation
assays and acquisition of the flat-cell phenotype.
Signal peptide peptidase (SPP) is an aspartic proteinase that hydrolyses its
substrate within the plane of the cellular membrane. In vertebrates, it plays
crucial roles in life processes such as differentiation, embryogenesis, cell
signaling and immunological response. We first found SPP in plants. An
ortholog of human SPP (AtSPP), and its five AtSPP homologs (AtSPPL1–
AtSPPL5), were searched for in theArabidopsisdatabase.
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters.
This volume is the first book-length survey of caveolae and lipid rafts. Interest has
developed rapidly in the role of these surface microdomains in such diverse fields
as transmembrane signaling, cell locomotion, vascular relaxation, senescence, and
the uptake and exit from cells of viruses and bacteria. Individual chapters in this
volume cover areas as diverse as the forces that induce and maintain membrane
invaginations, and the clinical relevance of multiprotein complexes at the cell surface,
defects in which are associated with cancer, and Alzheimer’s and prion-dependent
Tumor angiogenesis is a complex process involving many different cell types that must proliferate, migrate, invade, and differentiate in response to signals from the tumor microenvironment. Endothelial cells (ECs) sprout from host vessels in response to VEGF, bFGF, Ang2, and other proangiogenic stimuli. Sprouting is stimulated by VEGF/VEGFR2, Ang2/Tie-2, and integrin/extracellular matrix (ECM) interactions.
Oncogene signaling pathways are activated during tumor progression and promote metastatic potential.
This figure shows a cancer cell that has undergone epithelial to mesenchymal transition (EMT) under the influence of several environmental signals. Critical components include activated transforming growth factor beta (TGF-β) and the hepatocyte growth factor (HGF)/c-Met pathways, as well as changes in the expression of adhesion molecules that mediate cell-cell and cellextracellular matrix interactions.