Tham khảo sách 'technology in action™learn electronics with arduino learn electronics concepts while building', kỹ thuật - công nghệ, tự động hoá phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
Th ere is something about being human that instills in us a sense of wonder.
When we stop to think about it, the very idea of life seems such a mystery.
Where did we come from? How did life begin? When we look at the
sky, we wonder about the vastness of the universe and whether other life
may exist there. If we look through a microscope at a drop of pond water,
we are amazed at the variety of tiny creatures we see.
Since cells form the very basis of life, it is only natural that our sense
of wonder extends to the cell. Where did...
We have previously demonstrated that the steroid hormone
1a,25(OH)2-vitamin D3 [1a,25(OH)2D3] stimulates the
production ofinositol trisphosphate (InsP3), the breakdown
product ofphosphatidylinositol 4,5-biphosphate (PtdInsP2)
by phospholipase C (PtdIns-PLC), and activates the cyto-solic tyrosine kinase c-Src in skeletal muscle cells. In the
present study we examined whether 1a,25(OH)2D3induces
the phosphorylation and membrane translocation ofPLCc
and the mechanism involved in this isozyme activation. ...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor...
Local anaesthetics reversibly block neural transmission in local tissues. The drugs are bound with specific receptors located inside the sodium channels of cell membranes, and thus block the permeability of sodium ions; this is the mechanism of anaesthetic action of these drugs. As the history of local anaesthetics, Von Anrep discovered the local anaesthetic action of an alkaloid cocaine being contained in the leaves of Erythroxylon coca. Then, Karl Koller used cocaine as a local anaesthetic in ophthalmological surgery.
Cresol is being used for an antiseptic, disinfectant, maggot-killing agent and cresol soap solution. Since various kinds of more powerful and odorless disinfectants have nowadays become available in practical use, the frequency in the use of cresol seems decreasing. However, the cases of acute poisoning by cresol are still being reported at the present time. The toxic effects of cresol are due to its corrosive actions, resulting in the destruction of cell membranes and coagulation of proteins, and its suppressive action on the central nervous system .
The present book is a collection of selected original research articles and reviews providing adequate and up-to-date information related to pesticides control, assessment, and toxicity. The first section covers a large spectrum of issues associated with the ecological, molecular, and biotechnological approaches to the understanding of the biological control, the mechanism of the biocontrol agents action, and the related effects.
PI3K is a heterodimeric lipid kinase that catalyses the conversion of phosphatidylinositol bisphosphate (PIP2) to phosphatidylinositol trisphosphate (PIP3), which acts as a plasma membrane docking site for proteins that contain a pleckstrin homology (PH) domain. These include the serine/threonine kinases Akt and PDK1 that are key downstream effectors of PI3K action (Fig. 80-2). The PI3K pathway is activated in 30–40% of human cancers and is thought to play a critical role in tumor cell survival, proliferation, growth, and glucose utilization.
The cytotoxic action of some ribonucleases homologous to bovine pancre-atic RNase A, the superfamily prototype, has interested and intrigued
investigators. Their ribonucleolytic activity is essential for their cytotoxic
action, and their target RNA is in the cytosol. It has been proposed that
the cytosolic RNase inhibitor (cRI) plays a major role in determining the
ability of an RNase to be cytotoxic.
The governments of Finland and Korea both have demonstrated during past downturns that
bold innovation policy initiatives can accelerate structural changes which face high obstacles in
normal times (Box 1). Such initiatives require proper framework conditions and a coherent crisis
Anti-crisis policy measures can provide built-in incentives to innovate
Clearly, innovation will be one of the keys to emerging from the downturn and putting countries
back on a path to sustainable – and smarter – growth.
In this report we are suggesting that Congress consider clarifying whether
Education may regulate loan origination fees charged to borrowers under
the Direct Loan Program. In addition, we are recommending that FSA’s
Chief Operating Officer take actions to collect information from schools
that have left the Direct Loan Program about the factors that influenced
this decision, information that could be used to make improvements to the
Direct Loan Program, thereby helping FSA meet its goal of improving
The 2012 Towers Watson/National Business
Group on Health Employer Survey on Purchasing
Value in Health Care provides many strategic
insights into the actions and plans of leading U.S.
employers. It also offers views of what the future
of employer-provided health care in the U.S. may
look like this year and in the coming three years.
This analysis comes at a time when employers are
still facing a number of long-term challenges, such
as controlling growing costs, improving employee
engagement and accountability, and optimizing the
total rewards mix.
Population trends affect the course of and prospects for poverty reduction.
Diverse and changing population dynamics have had dramatic impacts in sev-
eral world regions. Sub-Saharan Africa remains in a poverty trap where demo-
graphic factors – high fertility, high infant and child mortality, and excess
adult mortality (including that due to HIV/AIDS) – play significant roles.
Eastern Asia, on the other hand, has seen dramatic declines in the number
of persons living in income poverty.
In the figure shown here (Figure 1), teaching contributes to the development of pupils’ action
competence, which in turn should enable the pupils to act with regard to their own lives and living
conditions. Teaching and educational processes have been put in the center of this model in order to
stress that a health promoting school is not only about the food in the canteen, a smoke-free
environment etc. This also means that pupils and teachers are considered to be the key-players at a
health promoting school.
Scientists do not know exactly what causes most adrenal cortical tumors. Over the past
few years, they have made great progress in understanding how certain changes in a
person's DNA can cause cells in the adrenal gland to become cancerous. DNA is the
molecule that carries the instructions for nearly everything our cells do. We usually look
like our parents because they are the source of our DNA. However, DNA affects more
than the way we look. It also determines our risk for developing certain diseases,
including some types of cancer.
Increases in intracellular [Ca
] occur synchronously between cells in the
neuroepithelium. If neuroepithelial cells were capable of generating action
potentials synchronized by gap junctions (direct current electrical coupling),
the influx of Ca
through voltage-activated Ca
channels would lead to
a synchronous increase in intracellular [Ca
Previous studies have shown an anticancer effect of vitamin D, but the
mechanisms underlying this action have not been fully explored. Here we
show that 1,25-dihydroxyvitamin D3 (VD3, the active form of vitamin D)
significantly promoted apoptosis in the undifferentiated gastric cancer cell
line HGC-27, and this was accompanied by a concurrent increase in phos-phatase and tensin homolog deleted on chromosome 10 (PTEN) expression
on VD3 treatment.
The eosinophil cationic protein⁄RNase 3 and the skin-derived RNase 7 are
two human antimicrobial RNases involved in host innate immunity. Both
belong to the RNase A superfamily and share a high cationicity and a
common structural architecture.
Sodium 2-propenyl thiosulfate, a water-soluble organo-sulfane sulfur com-pound isolated from garlic, induces apoptosis in a number of cancer cells.
The molecular mechanism of action of sodium 2-propenyl thiosulfate has
not been completely clarified. In this work we investigated, byin vivo and
in vitro experiments, the effects of this compound on the expression and
activity of rhodanese.
As an essential element, selenium is present in enzymes from
several families, including glutathione peroxidases, and is
thought to exert anticarcinogenic properties. A remarkable
feature of selenium consists of its ability to oxidize thiols
under reducing conditions. Thus, one mode of action
recently suggested is the oxidation of thiol groups of metal-lothionein, thereby providing zinc for essential reactions.