Cellular targets

Xem 1-20 trên 48 kết quả Cellular targets
  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 encoded candidate micro-RNAs and their cellular targets

    pdf5p toshiba16 27-10-2011 15 1   Download

  • Tham khảo sách 'cooperative robotics for multi target observation', kỹ thuật - công nghệ, tự động hoá phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Although mobile devices, cellular phones, Personal Digital Assistants (PDAs) and other handheld devices have hardware constraints such as small screen, small storage, low CPU speed, and low resolution, their popularity has been enormously increasing. This is enhancing the opportunities for researchers to overcome those open problems caused of small size hardware constraints. However, still the biggest difficulty is that these devices are too difficult to load today’s visual information because most current information is based on a large visual documentation.

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  • In light of the significant and multifaceted role neuronal, vascular, and inflammatory cells play during degenerative disorders, novel studies that elucidate the role of these cells may greatly further our understanding of disease mechanisms for the development of targeted treatments for a wide spectrum of diseases.

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  • This book presents basic and advanced principles underlying the multivalent interactions that are prevalent in biological systems. To illustrate important or complex concepts, the book provides up-to-date examples of synthetic multivalent molecules, their design, and their biological benefits. Functional roles displayed by such molecules of both natural and synthetic origin are well documented in biology, where they exert unique and crucial activities at a level not readily achievable by monovalent molecules.

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  • Review Identifying transcriptional targets Nicola V Taverner, James C Smith and Fiona C Wardle Addresses: Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK. Correspondence: Fiona C Wardle. E-mail: f.wardle@welc.cam.ac.uk comment reviews Published: 27 February 2004 Genome Biology 2004, 5:210 The electronic version of this article is the complete one and can be found online at http://genomebiology.

    pdf0p thulanh21 15-11-2011 27 4   Download

  • All Americans have a stake in effective response to hate crimes. These crimes demand priority attention because of their special impact. Bias crimes are designed to intimidate the victim and members of the victim’s community, leaving them feeling isolated, vulnerable, and unprotected by the law. Failure to address this unique type of crime could cause an isolated incident to explode into widespread community tension. The damage done by hate crimes, therefore, cannot be measured solely in terms of physical injury or dollars and cents.

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  • The use of hospital admission rates for ambulatory care sensitive conditions (ACSCs) has become an established tool for analyzing access to care [1,2]. ACSCs are conditions for which good outpatient care can potentially prevent the need for hospitalization. High rates of hospital admissions for ACSCs may provide evidence of problems with patient access to primary healthcare, inadequate skills and resources, or a mismatch in services.

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  • Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design.

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  • RNA-mediated gene silencing (RNA interference) is a powerful way to knock down gene expression and has revolutionized the fields of cellular and molecular biology. Indeed, the transfection of cultured cells with small interfering RNAs (siRNAs) is currently considered to be the best and easi-est approach to loss-of-function experiments.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell’s palsy...

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  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution

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  • The enzyme fumarase is a conserved protein in all organisms with regard to its sequence, structure and function. This enzyme participates in the tri-carboxylic acid cycle in mitochondria which is essential for cellular respira-tion in eukaryotes.

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  • The mitogenic toxin fromPasteurella multocida(PMT) is a member of the dermonecrotic toxin family, which includes toxins fromBordetella, Escheri-chia coliandYersinia. Members of the dermonecrotic toxin family modu-late G-protein targets in host cells through selective deamidation and⁄or transglutamination of a critical active site Gln residue in the G-protein tar-get, which results in the activation of intrinsic GTPase activity.

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  • DNA tumor viruses ensure genome amplification by hijacking the cellular replication machinery and forcing infected cells to enter the S phase. The retinoblastoma (Rb) protein controls the G1⁄S checkpoint, and is targeted by several viral oncoproteins, among these the E7 protein from human papillomaviruses (HPVs).

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  • Drive diversity. Homogeneous systems are less resi lient than diversified ones. For example, in 2007, a virus killed millions of farmed Chilean salmon. The fish had been farmed at high density, treated with similar antibiotics and subjected to similar preventive measures. They were, therefore, all vulnerable to a single threat. Applying this lesson, financial institutions could encourage diverse and contrarian approaches towards modelling risk and selecting business strategies. Competitive forces would make this difficult to achieve at an institutional level.

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  • The mono(ADP-ribosyl)ation reaction is a post-translational modification that is catalysed by both bacterial toxins and eukaryotic enzymes, and that results in the transfer of ADP-ribose from bNAD + to various acceptor proteins. In mammals, both intracellular and extracellular reactions have been described; the latter are due to glycosylphosphatidylinositol-anchored or secreted enzymes that are able to modify their targets, which include the purinergic receptor P2X7, the defensins and the integrins. ...

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  • There is much evidence to indicate that cholesterol forms lateral membranemicrodomains (rafts), and to suggest their important role in cellular signaling. However, no probe has been produced to analyze cholesterol behavior, especially cholesterol movement in rafts, in real time. To obtain a potent tool for analyzing cholesterol dynamics in rafts, we prepared and characterized several truncated fragments of h-toxin (perfringolysin O), a cholesterol-binding cytolysin, whose chemicallymodified formhas been recently shown to bind selectively to rafts. ...

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  • "Molecular imaging" has been previously defined as "the in vivo characterization and measurement of biologic processes at the cellular and molecular level." This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell biology with imaging science, including medical physics and technology. One of the major goals of molecular imaging has become the development of noninvasive strategies of "molecular profiling" in living subjects, i.e.

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  • Targeting signals are critical for proteins to find their specific cellular desti-nation. Signals for protein targeting to the endoplasmic reticulum (ER), mitochondria, peroxisome and nucleus are distinct and the mechanisms of protein translocation across these membrane compartments also vary markedly.

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