Although mobile devices, cellular phones, Personal Digital Assistants (PDAs) and other
handheld devices have hardware constraints such as small screen, small storage, low CPU
speed, and low resolution, their popularity has been enormously increasing. This is
enhancing the opportunities for researchers to overcome those open problems caused of
small size hardware constraints. However, still the biggest difficulty is that these devices are
too difficult to load today’s visual information because most current information is based on
a large visual documentation.
In light of the significant and multifaceted role neuronal, vascular, and inflammatory cells play during degenerative disorders, novel studies that elucidate the role of these cells may greatly further our understanding of disease mechanisms for the development of targeted treatments for a wide spectrum of diseases.
This book presents basic and advanced principles underlying the multivalent
interactions that are prevalent in biological systems. To illustrate important or
complex concepts, the book provides up-to-date examples of synthetic multivalent
molecules, their design, and their biological benefits. Functional roles
displayed by such molecules of both natural and synthetic origin are well
documented in biology, where they exert unique and crucial activities at a
level not readily achievable by monovalent molecules.
Identifying transcriptional targets
Nicola V Taverner, James C Smith and Fiona C Wardle
Addresses: Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK. Correspondence: Fiona C Wardle. E-mail: email@example.com
Published: 27 February 2004 Genome Biology 2004, 5:210 The electronic version of this article is the complete one and can be found online at http://genomebiology.
Telomeres play an important role in cellular aging and cancer. Human
telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be
important for telomere biology and a good target for drug design.
All Americans have a stake in effective response to hate
crimes. These crimes demand priority attention because
of their special impact. Bias crimes are designed to
intimidate the victim and members of the victim’s
community, leaving them feeling isolated, vulnerable,
and unprotected by the law. Failure to address this
unique type of crime could cause an isolated incident to
explode into widespread community tension. The
damage done by hate crimes, therefore, cannot be
measured solely in terms of physical injury or dollars and
The use of hospital admission rates for ambulatory care
sensitive conditions (ACSCs) has become an established
tool for analyzing access to care [1,2]. ACSCs are conditions
for which good outpatient care can potentially prevent
the need for hospitalization. High rates of hospital
admissions for ACSCs may provide evidence of problems
with patient access to primary healthcare, inadequate
skills and resources, or a mismatch in services.
RNA-mediated gene silencing (RNA interference) is a powerful way to
knock down gene expression and has revolutionized the fields of cellular
and molecular biology. Indeed, the transfection of cultured cells with small
interfering RNAs (siRNAs) is currently considered to be the best and easi-est approach to loss-of-function experiments.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell’s palsy...
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution
The enzyme fumarase is a conserved protein in all organisms with regard
to its sequence, structure and function. This enzyme participates in the tri-carboxylic acid cycle in mitochondria which is essential for cellular respira-tion in eukaryotes.
The mitogenic toxin fromPasteurella multocida(PMT) is a member of the
dermonecrotic toxin family, which includes toxins fromBordetella, Escheri-chia coliandYersinia. Members of the dermonecrotic toxin family modu-late G-protein targets in host cells through selective deamidation and⁄or
transglutamination of a critical active site Gln residue in the G-protein tar-get, which results in the activation of intrinsic GTPase activity.
DNA tumor viruses ensure genome amplification by hijacking the cellular
replication machinery and forcing infected cells to enter the S phase. The
retinoblastoma (Rb) protein controls the G1⁄S checkpoint, and is targeted
by several viral oncoproteins, among these the E7 protein from human
Drive diversity. Homogeneous systems are less resi lient than diversified ones. For example, in 2007, a virus
killed millions of farmed Chilean salmon. The fish had been farmed at high density, treated with similar antibiotics
and subjected to similar preventive measures. They were, therefore, all vulnerable to a single threat. Applying
this lesson, financial institutions could encourage diverse and contrarian approaches towards modelling risk
and selecting business strategies. Competitive forces would make this difficult to achieve at an institutional level.
The mono(ADP-ribosyl)ation reaction is a post-translational modification
that is catalysed by both bacterial toxins and eukaryotic enzymes, and that
results in the transfer of ADP-ribose from bNAD
to various acceptor
proteins. In mammals, both intracellular and extracellular reactions have
been described; the latter are due to glycosylphosphatidylinositol-anchored
or secreted enzymes that are able to modify their targets, which include
the purinergic receptor P2X7, the defensins and the integrins. ...
There is much evidence to indicate that cholesterol forms
lateral membranemicrodomains (rafts), and to suggest their
important role in cellular signaling. However, no probe has
been produced to analyze cholesterol behavior, especially
cholesterol movement in rafts, in real time. To obtain a
potent tool for analyzing cholesterol dynamics in rafts, we
prepared and characterized several truncated fragments of
h-toxin (perfringolysin O), a cholesterol-binding cytolysin,
whose chemicallymodified formhas been recently shown to
bind selectively to rafts. ...
"Molecular imaging" has been previously defined as "the in vivo characterization and measurement of biologic processes at the cellular and molecular level." This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell biology with imaging science, including medical physics and technology. One of the major goals of molecular imaging has become the development of noninvasive strategies of "molecular profiling" in living subjects, i.e.
Targeting signals are critical for proteins to find their specific cellular desti-nation. Signals for protein targeting to the endoplasmic reticulum (ER),
mitochondria, peroxisome and nucleus are distinct and the mechanisms of
protein translocation across these membrane compartments also vary